The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Reprogramming Exosomes as Nanoscale Controllers of Cellular Immunity
Open accessAbstract
Exosomes are naturally occurring membranous vesicles secreted by various types of cells. Given their unique and important biological and pharmacological properties, exosomes have been emerging as a promising form of nanomedicine acting via efficient delivery of endogenous and exogenous therapeutics. Here we explore a new concept of utilizing endogenously derived exosomes as artificial controllers of cellular immunity to redirect and activate cytotoxic T cells toward cancer cells for killing. This was achieved through genetically displaying two distinct types of antibodies on exosomal surface. The resulting synthetic multivalent antibodies retargeted exosomes (SMART-Exos), which express monoclonal antibodies specific for T-cell CD3 and cancer cell-associated epidermal growth factor receptor (EGFR), were shown to not only induce cross-linking of T cells and EGFR-expressing breast cancer cells but also elicit potent antitumor immunity both in vitro and in vivo. This proof-of-concept study demonstrates a novel application of exosomes in cancer immunotherapy and may provide a general and versatile approach for the development of a new class of cell-free therapy.
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Cites
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Cited by
Engineering exosomes for targeted drug delivery
Liang, Y., Duan, L., Lu, J., & Xia, J. (2021) · Theranostics · doi:10.7150/thno.52570 · Cited by 1,547
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Engineered Extracellular Vesicles for Cancer Therapy
Zhang, X., Zhang, H., Gu, J., Zhang, J., Shi, H., Qian, H., Wang, D., Xu, W., Pan, J., & Santos, H. A. (2021) · Advanced Materials · doi:10.1002/adma.202005709 · Cited by 428
Shedding Light on Extracellular Vesicle Biogenesis and Bioengineering
Teng, F., & Fussenegger, M. (2021) · Advanced Science · doi:10.1002/advs.202003505 · Cited by 382
Extracellular vesicles: A bright star of nanomedicine
Wu, P., Zhang, B., Ocansey, D. K. W., Xu, W., & Qian, H. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2020.120467 · Cited by 368
Metadata
- Authors
- Cheng, Q., Shi, X., Han, M., Smbatyan, G., Lenz, H.-J., & Zhang, Y.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-11-19
- Volume
- 140
- Issue
- 48
- Pages
- 16413-16417
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2900972772
- Cited by
- 285
- References
- 41
- FWCI
- 6.83
- Type
- journal article
- Language
- en
- Open access
- green
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