The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
In Situ Monitoring Apoptosis Process by a Self-Reporting Photosensitizer
Abstract
Although photodynamic therapy (PDT) has thrived as a promising treatment, highly active photosensitizers (PSs) and intense light power can cause treatment overdose. However, extra therapeutic response probes make the monitoring process complicated, ex situ and delayed. Now, this challenge is addressed by a self-reporting cationic PS, named TPE-4EP+, with aggregation-induced emission characteristic. The molecule undergoes mitochondria-to-nucleus translocation during apoptosis induced by PDT, thus enabling the in situ real-time monitoring via fluorescence migration. Moreover, by molecular charge engineering, we prove that the in situ translocation of TPE-4EP+ is mainly attributed to the enhanced interaction with DNA imposed by its multivalent positive charge. The ability of PS to provide PDT with real-time diagnosis help control the treatment dose that can avoid excessive phototoxicity and minimize potential side effect. Future development of new generation of PS is envisioned.
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Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole
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Self-citationAggregation-Induced Emission: Together We Shine, United We Soar!
Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270
Self-citationMultidrug resistance in cancer: role of ATP–dependent transporters
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Seventeen-colour flow cytometry: unravelling the immune system
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Self-citationStrategies to Enhance the Photosensitization: Polymerization and the Donor–Acceptor Even–Odd Effect
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Self-citationWang, Y., Chen, M., Alifu, N., Li, S., Qin, W., Qin, A., Tang, B. Z., & Qian, J. (2017) · ACS Nano · doi:10.1021/acsnano.7b05645 · Cited by 177
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Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Supramolecular materials based on AIE luminogens (AIEgens): construction and applications
Li, J., Wang, J., Li, H., Song, N., Wang, D., & Tang, B. Z. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00495e · Cited by 741
Self-citationAggregation‐enhanced theranostics: AIE sparkles in biomedical field
Kang, M., Zhang, Z., Song, N., Li, M., Sun, P., Chen, X., Wang, D., & Tang, B. Z. (2020) · Aggregate · doi:10.1002/agt2.7 · Cited by 485
Self-citationLi, Y., Cai, Z., Liu, S., Zhang, H., Wong, S. T. H., Lam, J. W. Y., Kwok, R. T. K., Qian, J., & Tang, B. Z. (2020) · Nature Communications · doi:10.1038/s41467-020-15095-1 · Cited by 464
Self-citationThe fast-growing field of photo-driven theranostics based on aggregation-induced emission
Zhang, Z., Kang, M., Tan, H., Song, N., Li, M., Xiao, P., Yan, D., Zhang, L., Wang, D., & Tang, B. Z. (2022) · Chemical Society Reviews · doi:10.1039/d1cs01138c · Cited by 374
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Metadata
- Authors
- Zhang, T., Li, Y., Zheng, Z., Ye, R., Zhang, Y., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-03-28
- Volume
- 141
- Issue
- 14
- Pages
- 5612-5616
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2932316615
- Cited by
- 235
- References
- 9
- FWCI
- 26.19
- Type
- journal article
- Language
- en
- Open access
- closed
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