The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Cancer Chemopreventive and Antioxidant Activities of Pterostilbene, a Naturally Occurring Analogue of Resveratrol
Abstract
Pterostilbene, a natural methoxylated analogue of resveratrol, was evaluated for antioxidative potential. The peroxyl-radical scavenging activity of pterostilbene was the same as that of resveratrol, having total reactive antioxidant potentials of 237 +/- 58 and 253 +/- 53 microM, respectively. Both compounds were found to be more effective than Trolox as free radical scavengers. Using a plant system, pterostilbene also was shown to be as effective as resveratrol in inhibiting electrolyte leakage caused by herbicide-induced oxidative damage, and both compounds had the same activity as alpha-tocopherol. Pterostilbene showed moderate inhibition (IC50 = 19.8 microM) of cyclooxygenase (COX)-1, and was weakly active (IC50 = 83.9 microM) against COX-2, whereas resveratrol strongly inhibited both isoforms of the enzyme with IC50 values of approximately 1 microM. Using a mouse mammary organ culture model, carcinogen-induced preneoplastic lesions were, similarly to resveratrol, significantly inhibited by pterostilbene (ED50 = 4.8 microM), suggesting antioxidant activity plays an important role in this process.
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Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
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Self-citationWine, alcohol, platelets, and the French paradox for coronary heart disease
Renaud, S., & de Lorgeril, M. (1992) · The Lancet · doi:10.1016/0140-6736(92)91277-f · Cited by 3,643
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Abbott, L. F., Varela, J. A., Sen, K., & Nelson, S. B. (1997) · Science · doi:10.1126/science.275.5297.221 · Cited by 1,690
Inhibition of human LDL oxidation by resveratrol
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Natural polyphenols in cancer therapy
Asensi, M., Ortega, A., Mena, S., Feddi, F., & Estrela, J. M. (2011) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2011.631268 · Cited by 174
α-Glucosidase inhibitory effect of resveratrol and piceatannol
Zhang, A. J., Rimando, A. M., Mizuno, C. S., & Mathews, S. T. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.05.008 · Cited by 99
Self-citation
Metadata
- Authors
- Rimando, A. M., Cuendet, M., Desmarchelier, C., Mehta, R. G., Pezzuto, J. M., & Duke, S. O.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-05-10
- Volume
- 50
- Issue
- 12
- Pages
- 3453-3457
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2037231157
- Cited by
- 295
- References
- 26
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- closed
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