Oxidation of quercetin by salivary components. Quercetin-dependent reduction of salivary nitrite under acidic conditions producing nitric oxide
Abstract
Under acidic conditions, nitrite is protonated to nitrous acid (pK(a) = 3.2-3.4) that can be transformed into nitric oxide by self-decomposition and reduction. When sodium nitrite was mixed with quercetin at pH 1-2, quercetin was oxidized producing nitric oxide. In addition to quercetin, kaempferol and quercetin 4'-glucoside were also oxidized by nitrous acid, but oxidation of apigenin, luteolin, and rutin was slow compared to oxidation of the above flavonols. These results suggested that flavonols, which have a free hydroxyl group at carbon position 3, can readily reduce nitrous acid to nitric oxide. When the pH of saliva was decreased to 1-2, formation of nitric oxide was observed. The nitric oxide formation was enhanced by quercetin, and during this process quercetin was oxidized. These results indicate that there is a possibility of reactions between phenolics and nitrous acid derived from salivary nitrite in the stomach.
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NO production in the stomach is greatly enhanced in the presence of dietary polyphenols and ascorbic acid.
“the NO production in the stomach is greatly enhanced in the presence of dietary polyphenols [24] and ascorbic acid [15]”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [24]
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- Authors
- Takahama, U., Oniki, T., & Hirota, S.
- Affiliations
- Kyushu Women's University (JP)
- Corresponding author
- Takahama, Umeo
- ORCID
- Takahama, Umeo
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-06-12
- Volume
- 50
- Issue
- 15
- Pages
- 4317-4322
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2034780811
- Cited by
- 74
- References
- 28
- Citations by year
- 2026: 5 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 4 · 2012: 3
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Keywords
- quercetin, salivary nitrite, nitric oxide, nitrous acid, kaempferol, apigenin, luteolin, rutin, low pH, salivary pH, gastric acid
- MeSH terms
- Flavonoids, Humans, Hydrogen-Ion Concentration, Kinetics, Nitric Oxide, Nitrous Acid, Oxidation-Reduction, Quercetin, Saliva, Sodium Nitrite, Kaempferols
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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