The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Amelioration of Obesity and Glucose Intolerance in High-Fat-Fed C57BL/6 Mice by Anthocyanins and Ursolic Acid in Cornelian Cherry (Cornus mas)
Abstract
Much attention has been focused on food that may be beneficial in preventing diet-induced body fat accumulation and possibly reduce the risk of diabetes and heart disease. Cornelian cherries (Cornus mas) are used in the preparation of beverages in Europe and also to treat diabetes-related disorders in Asia. In this study, the most abundant bioactive compounds in C. mas fruits, the anthocyanins and ursolic acid, were purified, and their ability to ameliorate obesity and insulin resistance in C57BL/6 mice fed a high-fat diet was evaluated. Mice were initially fed a high-fat diet for 4 weeks and then switched to a high-fat diet containing anthocyanins (1 g/kg of high-fat diet) and ursolic acid (500 mg/kg of high-fat diet) for an additional 8 weeks. The high-fat diet induced glucose intolerance, and this was prevented by anthocyanins and ursolic acid. The anthocyanin-treated mice showed a 24% decrease in weight gain. These mice also showed decreased lipid accumulation in the liver, including a significant decrease in liver triacylglycerol concentration. Anthocyanin and ursolic acid treated mice exhibited extremely elevated insulin levels. Both treatments, however, showed preserved islet architecture and insulin staining. Overall, these data suggest that anthocyanins and ursolic acid purified from C. mas fruits have biological activities that improve certain metabolic parameters associated with diets high in saturated fats and obesity.
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Cites
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Self-citationInsulin Secretion by Bioactive Anthocyanins and Anthocyanidins Present in Fruits
Jayaprakasam, B., Vareed, S. K., Olson, L. K., & Nair, M. G. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf049018+ · Cited by 425
Self-citationRamirez-Tortosa, C., Andersen, Ø. M., Gardner, P. T., Morrice, P. C., Wood, S. G., Duthie, S. J., Collins, A. R., & Duthie, G. G. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00618-9 · Cited by 264
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Molecular Targets for Bioactive Food Components
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Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids
Kawser Hossain, M., Abdal Dayem, A., Han, J., Yin, Y., Kim, K., Kumar Saha, S., Yang, G.-M., Choi, H., & Cho, S.-G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040569 · Cited by 495
Oxidative Stress as a Critical Factor in Nonalcoholic Fatty Liver Disease Pathogenesis
Spahis, S., Delvin, E., Borys, J.-M., & Levy, E. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6776 · Cited by 386
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Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea
Sato, H., Genet, C., Strehle, A., Thomas, C., Lobstein, A., Wagner, A., Mioskowski, C., Auwerx, J., & Saladin, R. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.06.130 · Cited by 340
Metadata
- Authors
- Jayaprakasam, B., Olson, L. K., Schutzki, R. E., Tai, M.-H., & Nair, M. G.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-12-08
- Volume
- 54
- Issue
- 1
- Pages
- 243-248
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2083754959
- Cited by
- 386
- References
- 14
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jayaprakasam, B., Olson, L. K., Schutzki, R. E., Tai, M.-H., & Nair, M. G. (2006). Amelioration of Obesity and Glucose Intolerance in High-Fat-Fed C57BL/6 Mice by Anthocyanins and Ursolic Acid in Cornelian Cherry (Cornus mas). Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/jf0520342
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