The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Bioaccessibility of Carotenoids and Vitamin E from Their Main Dietary Sources
Abstract
Vitamin E and carotenoids are fat-soluble microconstituents that may exert beneficial effects in humans, including protection against cancer, cardiovascular diseases, and age-related eye diseases. Their bioavailability is influenced by various factors including food matrix, formulation, and food processing. Since human studies are labor-intensive, time-consuming, and expensive, the in vitro model used in this study is increasingly being used to estimate bioaccessibility of these microconstituents. However, the ability of this model to predict bioavailability in a healthy human population has not yet been verified. The first aim of this study was to validate this model by comparing model-derived bioaccessibility data with (i) human-derived bioaccessibility data and (ii) published mean bioavailability data reported in studies involving healthy humans. The second aim was to use it to measure alpha- and gamma-tocopherol, beta-carotene, lycopene, and lutein bioaccessibility from their main dietary sources. Bioaccessibility as assessed with the in vitro model was well correlated with human-derived bioaccessibility values (r = 0.90, p < 0.05), as well as relative mean bioavailability values reported in healthy human groups (r = 0.98, p < 0.001). The bioaccessibility of carotenoids and vitamin E from the main dietary sources was highly variable, ranging from less than 0.1% (beta-carotene from raw tomato) to almost 100% (alpha-tocopherol from white bread). Bioaccessibility was dependent on (i) microconstituent species (lutein > beta-carotene and alpha-carotene > lycopene and alpha-tocopherol generally > gamma-tocopherol), (ii) food matrix, and (iii) food processing.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hydrogen peroxide scavenging, antioxidant and anti-radical activity of some phenolic acids
Sroka, Z., & Cisowski, W. (2003) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(02)00329-0 · Cited by 944
Caco-2 Cell Monolayers as a Model for Drug Transport Across the Intestinal Mucosa
Hilgers, A. R., Conradi, R. A., & Burton, P. S. (1990) · Pharmaceutical Research · doi:10.1023/a:1015937605100 · Cited by 587
Food Composition and Nutrition Tables
Rivera-Dommarco, J. A. (2001) · Archives of Medical Research · doi:10.1016/s0188-4409(01)00257-0 · Cited by 518
Estimation of carotenoid accessibility from carrots determined by an in vitro digestion method
Hedrén, E., Diaz, V, & Svanberg, U. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601329 · Cited by 350
Gastrointestinal absorption of drugs: methods and studies
Barthe, L., Woodley, J., & Houin, G. (1999) · Fundamental & Clinical Pharmacology · doi:10.1111/j.1472-8206.1999.tb00334.x · Cited by 290
Bioavailability and metabolism
Stahl, W. (2002) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(02)00016-x · Cited by 286
Some Dietary Fibers Reduce the Absorption of Carotenoids in Women
Riedl, J., Linseisen, J., Hoffmann, J., & Wolfram, G. (1999) · The Journal of Nutrition · doi:10.1093/jn/129.12.2170 · Cited by 265
Processing of vegetable-borne carotenoids in the human stomach and duodenum
Tyssandier, V., Reboul, E., Dumas, J.-F., Bouteloup-Demange, C., Armand, M., Marcand, J., Sallas, M., & Borel, P. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00410.2002 · Cited by 262
Self-citationBioavailability of lutein from vegetables is 5 times higher than that of β-carotene
van het Hof, K. H., Brouwer, I. A., West, C. E., Haddeman, E., Steegers-Theunissen, R. P., van Dusseldorp, M., Weststrate, J. A., Eskes, T. K., & Hautvast, J. G. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn.70.2.261 · Cited by 243
Borel, P. (2003) · Clinical Chemistry and Laboratory Medicine · doi:10.1515/cclm.2003.151 · Cited by 241
Self-citation
Cited by
A standardised static in vitro digestion method suitable for food – an international consensus
Minekus, M., Alminger, M., Alvito, P., Ballance, S., Bohn, T., Bourlieu, C., Carrière, F., Boutrou, R., Corredig, M., Dupont, D., et al. (2014) · Food Funct. · doi:10.1039/c3fo60702j · Cited by 5,824
INFOGEST static in vitro simulation of gastrointestinal food digestion
Brodkorb, A., Egger, L., Alminger, M., Alvito, P., Assunção, R., Ballance, S., Bohn, T., Bourlieu-Lacanal, C., Boutrou, R., Carrière, F., et al. (2019) · Nature Protocols · doi:10.1038/s41596-018-0119-1 · Cited by 5,199
Role of ROS and Nutritional Antioxidants in Human Diseases
Liu, Z., Ren, Z., Zhang, J., Chuang, C.-C., Kandaswamy, E., Zhou, T., & Zuo, L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00477 · Cited by 860
Biomarkers in nutritional epidemiology: applications, needs and new horizons
Jenab, M., Slimani, N., Bictash, M., Ferrari, P., & Bingham, S. A. (2009) · Human Genetics · doi:10.1007/s00439-009-0662-5 · Cited by 448
Etcheverry, P., Grusak, M. A., & Fleige, L. E. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00317 · Cited by 391
Metadata
- Authors
- Reboul, E., Richelle, M., Perrot, E., Desmoulins-Malezet, C., Pirisi, V., & Borel, P.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-10-13
- Volume
- 54
- Issue
- 23
- Pages
- 8749-8755
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W1980511079
- Cited by
- 444
- References
- 27
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Bioaccessibility of Carotenoids and Vitamin E from Their Main Dietary Sources. https://app.cochat.ai/papers/10.1021/jf061818s
- The paper
- Reboul, E., Richelle, M., Perrot, E., Desmoulins-Malezet, C., Pirisi, V., & Borel, P. (2006). Bioaccessibility of Carotenoids and Vitamin E from Their Main Dietary Sources. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/jf061818s
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
