The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
PLGA Nanoparticles Improve the Oral Bioavailability of Curcumin in Rats: Characterizations and Mechanisms
Abstract
The overall goal of this paper was to develop poly(lactic-co-glycolic acid) nanoparticles (PLGA-NPs) of curcumin (CUR), named CUR-PLGA-NPs, and to study the effect and mechanisms enhancing the oral bioavailability of CUR. CUR-PLGA-NPs were prepared according to a solid-in-oil-in-water (s/o/w) solvent evaporation method and exhibited a smooth and spherical shape with diameters of about 200 nm. Characterization of CUR-PLGA-NPs showed CUR was successfully encapsulated on the PLGA polymer. The entrapment efficiency and loading rate of CUR were 91.96 and 5.75%, respectively. CUR-PLGA-NPs showed about 640-fold in water solubility relative to that of n-CUR. A sustained CUR release to a total of approximately 77% was discovered from CUR-PLGA-NPs in artificial intestinal juice, but only about 48% in artificial gastric juice. After oral administration of CUR-PLGA-NPs, the relative bioavailability was 5.6-fold and had a longer half-life compared with that of native curcumin. The results showed that the effect in improving oral bioavailability of CUR may be associated with improved water solubility, higher release rate in the intestinal juice, enhanced absorption by improved permeability, inhibition of P-glycoprotein (P-gp)-mediated efflux, and increased residence time in the intestinal cavity. Thus, encapsulating hydrophobic drugs on PLGA polymer is a promising method for sustained and controlled drug delivery with improved bioavailability of Biopharmaceutics Classification System (BCS) class IV, such as CUR.
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1 retracted
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RetractedBioavailability of curcumin: Problems and promises
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Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs
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Curcumin Nanoparticles: Preparation, Characterization, and Antimicrobial Study
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Cited by
Oral bioavailability of curcumin: problems and advancements
Liu, W., Zhai, Y., Heng, X., Che, F. Y., Chen, W., Sun, D., & Zhai, G. (2016) · Journal of Drug Targeting · doi:10.3109/1061186x.2016.1157883 · Cited by 566
Combined effect of PLGA and curcumin on wound healing activity
Chereddy, K. K., Coco, R., Memvanga, P. B., Ucakar, B., des Rieux, A., Vandermeulen, G., & Préat, V. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.07.015 · Cited by 288
Temperature-dependent structure stability and in vitro release of chitosan-coated curcumin liposome
Liu, Y., Liu, D., Zhu, L., Gan, Q., & Le, X. (2015) · Food Research International · doi:10.1016/j.foodres.2015.04.024 · Cited by 279
Overview of metabolism and bioavailability enhancement of polyphenols
Lewandowska, U., Szewczyk, K., Hrabec, E., Janecka, A., & Gorlach, S. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf404439b · Cited by 196
Wu, P., Zhou, Q., Zhu, H., Zhuang, Y., & Bao, J. (2020) · BMC Cancer · doi:10.1186/s12885-020-06803-7 · Cited by 97
Self-citationRetracted
Metadata
- Authors
- Xie, X., Tao, Q., Zou, Y., Zhang, F., Guo, M., Wang, Y., Wang, H., Zhou, Q., & Yu, S.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-08-08
- Volume
- 59
- Issue
- 17
- Pages
- 9280-9289
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2017451930
- Cited by
- 393
- References
- 34
- FWCI
- 10.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Xie, X., Tao, Q., Zou, Y., Zhang, F., Guo, M., Wang, Y., Wang, H., Zhou, Q., & Yu, S. (2011). PLGA Nanoparticles Improve the Oral Bioavailability of Curcumin in Rats: Characterizations and Mechanisms. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/jf202135j
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