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PLGA Nanoparticles Improve the Oral Bioavailability of Curcumin in Rats: Characterizations and Mechanisms
Abstract
The overall goal of this paper was to develop poly(lactic-co-glycolic acid) nanoparticles (PLGA-NPs) of curcumin (CUR), named CUR-PLGA-NPs, and to study the effect and mechanisms enhancing the oral bioavailability of CUR. CUR-PLGA-NPs were prepared according to a solid-in-oil-in-water (s/o/w) solvent evaporation method and exhibited a smooth and spherical shape with diameters of about 200 nm. Characterization of CUR-PLGA-NPs showed CUR was successfully encapsulated on the PLGA polymer. The entrapment efficiency and loading rate of CUR were 91.96 and 5.75%, respectively. CUR-PLGA-NPs showed about 640-fold in water solubility relative to that of n-CUR. A sustained CUR release to a total of approximately 77% was discovered from CUR-PLGA-NPs in artificial intestinal juice, but only about 48% in artificial gastric juice. After oral administration of CUR-PLGA-NPs, the relative bioavailability was 5.6-fold and had a longer half-life compared with that of native curcumin. The results showed that the effect in improving oral bioavailability of CUR may be associated with improved water solubility, higher release rate in the intestinal juice, enhanced absorption by improved permeability, inhibition of P-glycoprotein (P-gp)-mediated efflux, and increased residence time in the intestinal cavity. Thus, encapsulating hydrophobic drugs on PLGA polymer is a promising method for sustained and controlled drug delivery with improved bioavailability of Biopharmaceutics Classification System (BCS) class IV, such as CUR.
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Cites
1 retracted
Anand, P., Nair, H. B., Sung, B., Kunnumakkara, A. B., Yadav, V. R., Tekmal, R. R., & Aggarwal, B. B. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.09.003 · Cited by 574
RetractedBioavailability of curcumin: Problems and promises
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007) · Molecular Pharmaceutics · doi:10.1021/mp700113r · Cited by 5,543
Anticancer potential of curcumin: preclinical and clinical studies.
Aggarwal, B. B., Kumar, A. J., & Bharti, A. C. (2003) · PubMed · Cited by 2,550
Sharma, R. A., Gescher, A. J., & Steward, W. P. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.05.009 · Cited by 1,658
Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs
Vasconcelos, T., Sarmento, B., & Costa, P. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.09.005 · Cited by 1,566
Shaikh, J., Ankola, D. D., Beniwal, V., Singh, D., & Kumar, M. N. V. R. (2009) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2009.02.019 · Cited by 956
Curcumin Nanoparticles: Preparation, Characterization, and Antimicrobial Study
Bhawana, Basniwal, R. K., Buttar, H. S., Jain, V. K., & Jain, N. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf104402t · Cited by 863
Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles
Wischke, C., & Schwendeman, S. P. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.04.042 · Cited by 790
Synthesis and characterization of PLGA nanoparticles
Astete, C. E., & Sabliov, C. M. (2006) · Journal of Biomaterials Science, Polymer Edition · doi:10.1163/156856206775997322 · Cited by 776
Fonseca, C., Simões, S., & Gaspar, R. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00212-2 · Cited by 755
Zhou, H., S. Beevers, C., & Huang, S. (2011) · Current Drug Targets · doi:10.2174/138945011794815356 · Cited by 715
Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC–MS/MS
Yang, K.-Y., Lin, L.-C., Tseng, T.-Y., Wang, S.-C., & Tsai, T.-H. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2007.03.010 · Cited by 635
Antibacterial Activity of Turmeric Oil: A Byproduct from Curcumin Manufacture
Negi, P. S., Jayaprakasha, G. K., Jagan Mohan Rao, L., & Sakariah, K. K. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf990308d · Cited by 545
Shehzad, A., Wahid, F., & Lee, Y. S. (2010) · Archiv der Pharmazie · doi:10.1002/ardp.200900319 · Cited by 542
Mohanty, C., & Sahoo, S. K. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.04.062 · Cited by 530
Innovative Preparation of Curcumin for Improved Oral Bioavailability
Sasaki, H., Sunagawa, Y., Takahashi, K., Imaizumi, A., Fukuda, H., Hashimoto, T., Wada, H., Katanasaka, Y., Kakeya, H., Fujita, M., et al. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.660 · Cited by 450
Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy.
Mukerjee, A., & Vishwanatha, J. K. (2009) · PubMed · Cited by 444
Takahashi, M., Uechi, S., Takara, K., Asikin, Y., & Wada, K. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9013923 · Cited by 391
Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin
Kakkar, V., Singh, S., Singla, D., & Kaur, I. P. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000310 · Cited by 348
Conjugation of curcumin onto hyaluronic acid enhances its aqueous solubility and stability
Manju, S., & Sreenivasan, K. (2011) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2011.03.071 · Cited by 299
Yen, F.-L., Wu, T.-H., Tzeng, C.-W., Lin, L.-T., & Lin, C.-C. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf100135h · Cited by 295
Wahlang, B., Pawar, Y. B., & Bansal, A. K. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.12.006 · Cited by 259
Komiya, I., Park, J. Y., Kamani, A., Ho, N. F. H., & Higuchi, W. I. (1980) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(80)90140-4 · Cited by 230
Collnot, E.-M., Baldes, C., Schaefer, U. F., Edgar, K. J., Wempe, M. F., & Lehr, C.-M. (2010) · Molecular Pharmaceutics · doi:10.1021/mp900191s · Cited by 219
Constantinides, P. P., & Wasan, K. M. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20780 · Cited by 207
The mechanism of enhancement on oral absorption of paclitaxel by N-octyl-O-sulfate chitosan micelles
Mo, R., Jin, X., Li, N., Ju, C., Sun, M., Zhang, C., & Ping, Q. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.03.005 · Cited by 198
Marcolino, V. A., Zanin, G. M., Durrant, L. R., Benassi, M. D. T., & Matioli, G. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf104223k · Cited by 182
Shono, Y., Nishihara, H., Matsuda, Y., Furukawa, S., Okada, N., Fujita, T., & Yamamoto, A. (2004) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20017 · Cited by 165
Tsai, Y.-M., Jan, W.-C., Chien, C.-F., Lee, W.-C., Lin, L.-C., & Tsai, T. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.01.059 · Cited by 152
Partial Correction of Cystic Fibrosis Defects with PLGA Nanoparticles Encapsulating Curcumin
Cartiera, M. S., Ferreira, E. C., Caputo, C. R., Egan, M. E., Caplan, M. J., & Saltzman, W. M. (2009) · Molecular Pharmaceutics · doi:10.1021/mp900138a · Cited by 149
Curcumin nanodisks: formulation and characterization
Ghosh, M., Singh, A. T. K., Xu, W., Sulchek, T., Gordon, L. I., & Ryan, R. O. (2010) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2010.08.002 · Cited by 143
Bansal, T., Mishra, G., Jaggi, M., Khar, R. K., & Talegaonkar, S. (2008) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2008.12.005 · Cited by 140
Yadav, A. K., Mishra, P., Mishra, A. K., Mishra, P., Jain, S., & Agrawal, G. P. (2007) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2007.09.004 · Cited by 138
Ling, G., Zhang, P., Zhang, W., Sun, J., Meng, X., Qin, Y., Deng, Y., & He, Z. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.08.010 · Cited by 136
Cited by
Oral bioavailability of curcumin: problems and advancements
Liu, W., Zhai, Y., Heng, X., Che, F. Y., Chen, W., Sun, D., & Zhai, G. (2016) · Journal of Drug Targeting · doi:10.3109/1061186x.2016.1157883 · Cited by 566
Combined effect of PLGA and curcumin on wound healing activity
Chereddy, K. K., Coco, R., Memvanga, P. B., Ucakar, B., des Rieux, A., Vandermeulen, G., & Préat, V. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.07.015 · Cited by 288
Temperature-dependent structure stability and in vitro release of chitosan-coated curcumin liposome
Liu, Y., Liu, D., Zhu, L., Gan, Q., & Le, X. (2015) · Food Research International · doi:10.1016/j.foodres.2015.04.024 · Cited by 279
Overview of metabolism and bioavailability enhancement of polyphenols
Lewandowska, U., Szewczyk, K., Hrabec, E., Janecka, A., & Gorlach, S. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf404439b · Cited by 196
Wu, P., Zhou, Q., Zhu, H., Zhuang, Y., & Bao, J. (2020) · BMC Cancer · doi:10.1186/s12885-020-06803-7 · Cited by 97
Self-citationRetracted
Metadata
- Authors
- Xie, X., Tao, Q., Zou, Y., Zhang, F., Guo, M., Wang, Y., Wang, H., Zhou, Q., & Yu, S.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-08-08
- Volume
- 59
- Issue
- 17
- Pages
- 9280-9289
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2017451930
- Cited by
- 393
- References
- 34
- FWCI
- 10.41
- Type
- journal article
- Language
- en
- Open access
- closed
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