The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Curcumin Nanoparticles Improve the Physicochemical Properties of Curcumin and Effectively Enhance Its Antioxidant and Antihepatoma Activities
Abstract
Curcumin (CUR), a natural polyphenol isolated from tumeric ( Curcuma longa ), has been documented to possess antioxidant and anticancer activities. Unfortunately, the compound has poor aqueous solubility, which results in poor bioavailability following high doses by oral administration. To improve the solubility of CUR, we developed a novel curcumin nanoparticle system (CURN) and investigated its physicochemical properties as well as its enhanced dissolution mechanism. Our results indicated that CURN improved the physicochemical properties of CUR, including a reduction in particle size and the formation of an amorphous state with hydrogen bonding, both of which increased the drug release of the compound. Moreover, in vitro studies indicated that CURN significantly enhanced the antioxidant and antihepatoma activities of CUR (P < 0.05). Consequently, we suggest that CURN can be used to reduce the dosage of CUR and improve its bioavailability and merits further investigation for therapeutic applications.
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Cites
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Cited by
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Everted gut sac model as a tool in pharmaceutical research: limitations and applications
Alam, M. A., Al-Jenoobi, F. I., & Al-mohizea, A. M. (2012) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2011.01391.x · Cited by 221
Metadata
- Authors
- Yen, F.-L., Wu, T.-H., Tzeng, C.-W., Lin, L.-T., & Lin, C.-C.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-05-20
- Volume
- 58
- Issue
- 12
- Pages
- 7376-7382
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2039732615
- Cited by
- 295
- References
- 25
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yen, F.-L., Wu, T.-H., Tzeng, C.-W., Lin, L.-T., & Lin, C.-C. (2010). Curcumin Nanoparticles Improve the Physicochemical Properties of Curcumin and Effectively Enhance Its Antioxidant and Antihepatoma Activities. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/jf100135h
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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