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Different Phenolic Compounds Activate Distinct Human Bitter Taste Receptors
Abstract
Bitterness is a major sensory attribute of several common foods and beverages rich in polyphenol compounds. These compounds are reported as very important for health as chemopreventive compounds, but they are also known to taste bitter. In this work, the activation of the human bitter taste receptors, TAS2Rs, by six polyphenol compounds was analyzed. The compounds chosen are present in a wide range of plant-derived foods and beverages, namely, red wine, beer, tea, and chocolate. Pentagalloylglucose (PGG) is a hydrolyzable tannin, (-)-epicatechin is a precursor of condensed tannins, procyanidin dimer B3 and trimer C2 belong to the condensed tannins, and malvidin-3-glucoside and cyanidin-3-glucoside are anthocyanins. The results show that the different compounds activate different combinations of the ~25 TAS2Rs. (-)-Epicatechin activated three receptors, TAS2R4, TAS2R5, and TAS2R39, whereas only two receptors, TAS2R5 and TAS2R39, responded to PGG. In contrast, malvidin-3-glucoside and procyanidin trimer stimulated only one receptor, TAS2R7 and TAS2R5, respectively. Notably, tannins are the first natural agonists found for TAS2R5 that display high potency only toward this receptor. The catechol and/or galloyl groups appear to be important structural determinants that mediate the interaction of these polyphenolic compounds with TAS2R5. Overall, the EC(50) values obtained for the different compounds vary 100-fold, with the lowest values for PGG and malvidin-3-glucoside compounds, suggesting that they could be significant polyphenols responsible for the bitterness of fruits, vegetables, and derived products even if they are present in very low concentrations.
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Cites
Wine, alcohol, platelets, and the French paradox for coronary heart disease
Renaud, S., & de Lorgeril, M. (1992) · The Lancet · doi:10.1016/0140-6736(92)91277-f · Cited by 3,643
Phenol-Explorer: an online comprehensive database on polyphenol contents in foods
Neveu, V., Perez-Jimenez, J., Vos, F., Crespy, V., du Chaffaut, L., Mennen, L., Knox, C., Eisner, R., Cruz, J., Wishart, D., et al. (2010) · Database · doi:10.1093/database/bap024 · Cited by 1,439
T2Rs Function as Bitter Taste Receptors
Chandrashekar, J., Mueller, K. L., Hoon, M. A., Adler, E., Feng, L., Guo, W., Zuker, C. S., & Ryba, N. J. P. (2000) · Cell · doi:10.1016/s0092-8674(00)80706-0 · Cited by 1,401
A Novel Family of Mammalian Taste Receptors
Adler, E., Hoon, M. A., Mueller, K. L., Chandrashekar, J., Ryba, N. J. P., & Zuker, C. S. (2000) · Cell · doi:10.1016/s0092-8674(00)80705-9 · Cited by 1,357
Bitter taste, phytonutrients, and the consumer: a review
Drewnowski, A., & Gomez-Carneros, C. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.6.1424 · Cited by 1,353
The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors
Meyerhof, W., Batram, C., Kuhn, C., Brockhoff, A., Chudoba, E., Bufe, B., Appendino, G., & Behrens, M. (2010) · Chemical Senses · doi:10.1093/chemse/bjp092 · Cited by 1,140
Self-citationA family of candidate taste receptors in human and mouse
Matsunami, H., Montmayeur, J.-P., & Buck, L. B. (2000) · Nature · doi:10.1038/35007072 · Cited by 718
Bufe, B., Breslin, P. A. S., Kuhn, C., Reed, D. R., Tharp, C. D., Slack, J. P., Kim, U.-K., Drayna, D., & Meyerhof, W. (2005) · Current Biology · doi:10.1016/j.cub.2005.01.047 · Cited by 708
Self-citationSoares, S., Mateus, N., & de Freitas, V. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf070905x · Cited by 535
Self-citationFlavonols, flavones and flavanols - nature, occurrence and dietary burden
Hollman, P. C., & Arts, I. C. (2000) · Journal of the Science of Food and Agriculture · doi:10.1002/(sici)1097-0010(20000515)80:7<1081::aid-jsfa566>3.0.co;2-g · Cited by 527
The receptors and coding logic for bitter taste
Mueller, K. L., Hoon, M. A., Erlenbach, I., Chandrashekar, J., Zuker, C. S., & Ryba, N. J. P. (2005) · Nature · doi:10.1038/nature03352 · Cited by 524
The human TAS2R16 receptor mediates bitter taste in response to β-glucopyranosides
Bufe, B., Hofmann, T., Krautwurst, D., Raguse, J.-D., & Meyerhof, W. (2002) · Nature Genetics · doi:10.1038/ng1014 · Cited by 431
Self-citationBitterness and astringency of flavan-3-ol monomers, dimers and trimers
Peleg, H., Gacon, K., Schlich, P., & Noble, A. C. (1999) · Journal of the Science of Food and Agriculture · doi:10.1002/(sici)1097-0010(199906)79:8<1123::aid-jsfa336>3.0.co;2-d · Cited by 402
Astringency and bitterness of selected phenolics in wine
Robichaud, J. L., & Noble, A. C. (1990) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2740530307 · Cited by 397
Brouillard, R., & Delaporte, B. (1977) · Journal of the American Chemical Society · doi:10.1021/ja00468a015 · Cited by 372
Bitter Taste Receptors for Saccharin and Acesulfame K
Kuhn, C., Bufe, B., Winnig, M., Hofmann, T., Frank, O., Behrens, M., Lewtschenko, T., Slack, J. P., Ward, C. D., & Meyerhof, W. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1225-04.2004 · Cited by 357
Self-citationVidal, S., Francis, L., Noble, A., Kwiatkowski, M., Cheynier, V., & Waters, E. (2004) · Analytica Chimica Acta · doi:10.1016/j.aca.2003.10.017 · Cited by 347
YAWADIO, R., TANIMORI, S., & MORITA, N. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2006.04.016 · Cited by 326
Zhang, J., Li, L., Kim, S.-H., Hagerman, A. E., & Lü, J. (2009) · Pharmaceutical Research · doi:10.1007/s11095-009-9932-0 · Cited by 294
Quantitative Reconstruction of the Nonvolatile Sensometabolome of a Red Wine
Hufnagel, J. C., & Hofmann, T. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf801742w · Cited by 286
The phenolics of ciders: Bitterness and astringency
Lea, A. G. H., & Arnold, G. M. (1978) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2740290512 · Cited by 272
The human taste receptor hTAS2R14 responds to a variety of different bitter compounds
Behrens, M., Brockhoff, A., Kuhn, C., Bufe, B., Winnig, M., & Meyerhof, W. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.019 · Cited by 229
Self-citationEndothelial function and cardiovascular disease: Effects of quercetin and wine polyphenols
Perez-Vizcaino, F., Duarte, J., & Andriantsitohaina, R. (2006) · Free Radical Research · doi:10.1080/10715760600823128 · Cited by 222
Elucidation of mammalian bitter taste
Meyerhof, W. (2005) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/s10254-005-0041-0 · Cited by 184
Self-citationDrayna, D. (2005) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.6.080604.162340 · Cited by 176
Pronin, A. N., Xu, H., Tang, H., Zhang, L., Li, Q., & Li, X. (2007) · Current Biology · doi:10.1016/j.cub.2007.07.046 · Cited by 170
Levels of Flavan-3-ols in French Wines
Carando, S., Teissèdre, P., Pascual-Martinez, L., & Cabanis, J. C. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9810564 · Cited by 124
Functional characterization of human bitter taste receptors
Sainz, E., Cavenagh, M. M., Gutierrez, J., Battey, J. F., Northup, J. K., & Sullivan, S. L. (2007) · Biochemical Journal · doi:10.1042/bj20061744 · Cited by 123
Antioxidant and Biological Properties of Bioactive Phenolic Compounds fromQuercus suberL.
Fernandes, A., Fernandes, I., Cruz, L., Mateus, N. F. D. C. B., Cabral, M., & de Freitas, V. A. P. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf902093m · Cited by 87
Self-citationChen, Y., & Hagerman, A. E. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf035536t · Cited by 78
Differentiation of human melanoma cells induced by cyanidin‐3‐ O ‐β‐glucopyranoside
Serafino, A., Vallebona, P. S., Lazzarino, G., Tavazzi, B., Rasi, G., Pierimarchi, P., Andreola, F., Moroni, G., Galvano, G., Galvano, F., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-1925fje · Cited by 58
Cited by
Plaskova, A., & Mlcek, J. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1118761 · Cited by 342
The Emerging Role of Polyphenols in the Management of Type 2 Diabetes
Wang, Y., Alkhalidy, H., & Liu, D. (2021) · Molecules · doi:10.3390/molecules26030703 · Cited by 88
De Camargo, A. C., Schwember, A. R., Parada, R., Garcia, S., Maróstica Júnior, M. R., Franchin, M., Regitano-d’Arce, M. A. B., & Shahidi, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113498 · Cited by 75
Metadata
- Authors
- Soares, S., Kohl, S., Thalmann, S., Mateus, N., Meyerhof, W., & De Freitas, V.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-02-06
- Volume
- 61
- Issue
- 7
- Pages
- 1525-1533
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2126834810
- Cited by
- 299
- References
- 31
- FWCI
- 14.16
- Type
- journal article
- Language
- en
- Open access
- closed
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