The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Endothelial function and cardiovascular disease: Effects of quercetin and wine polyphenols
Abstract
Endothelial dysfunction is an early pathophysiological feature and independent predictor of poor prognosis in most forms of cardiovascular diseases. Epidemiological studies report an inverse association between dietary flavonoid consumption and mortality from cardiovascular diseases. In the present paper, we review the effects of flavonoids, especially quercetin and wine polyphenols, on endothelial function and dysfunction and its potential protective role in hypertension, ischemic heart disease and stroke. In vitro studies show that flavonoids may exert multiple actions on the NO-guanylyl cyclase pathway, endothelium-derived hyperpolarizing factor(s) and endothelin-1 and protect endothelial cells against apoptosis. In vivo, flavonoids prevent endothelial dysfunction and reduce blood pressure, oxidative stress and end-organ damage in hypertensive animals. Moreover, some clinical studies have shown that flavonoid-rich foods can improve endothelial function in patients with hypertension and ischemic heart disease. Altogether, the available evidence indicates that quercetin and wine polyphenols might be of therapeutic benefit in cardiovascular diseases even though prospective controlled clinical studies are still lacking.
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Cites
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Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress
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The clinical implications of endothelial dysfunction
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Cited by
Flavonols and cardiovascular disease
Perez-Vizcaino, F., & Duarte, J. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.09.002 · Cited by 393
Self-citationNutrition concerns and health effects of vegetarian diets
Craig, W. J. (2010) · Nutrition in Clinical Practice · doi:10.1177/0884533610385707 · Cited by 370
Different Phenolic Compounds Activate Distinct Human Bitter Taste Receptors
Soares, S., Kohl, S., Thalmann, S., Mateus, N., Meyerhof, W., & De Freitas, V. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf304198k · Cited by 299
Bergmann, H., Rogoll, D., Scheppach, W., Melcher, R., & Richling, E. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800498 · Cited by 54
Liu, Y., Chen, X., & Li, J. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6304 · Cited by 39
“A number of molecular targets have been found to be modulated by resveratrol in several cardiovascular diseases, including atherosclerosis, hypertension and inflammation (28,29).”
Metadata
- Authors
- Perez-Vizcaino, F., Duarte, J., & Andriantsitohaina, R.
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2006-01
- Volume
- 40
- Issue
- 10
- Pages
- 1054-1065
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W1973436869
- Cited by
- 222
- References
- 9
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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