The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Structure−Function Relationships of Anthocyanins from Various Anthocyanin-Rich Extracts on the Inhibition of Colon Cancer Cell Growth
Abstract
Anthocyanins are potent antioxidants and may be chemoprotective. However, the structure-function relationships are not well understood. The objectives of this study were to compare the chemoprotective properties of anthocyanin-rich extracts (AREs) with variable anthocyanin profiles to understand the relationship between anthocyanin chemical structure and chemoprotective activity, measured as inhibition of colon cancer cell proliferation. Additionally, the chemoprotective interaction of anthocyanins and other phenolics was investigated. AREs with different anthocyanin profiles from purple corn, chokeberry, bilberry, purple carrot, grape, radish, and elderberry were tested for growth inhibition (GI 50) using a human colorectal adenocarcinoma (HT29) cell line. All AREs suppressed HT29 cell growth to various degrees as follows: purple corn (GI 50 approximately 14 microg of cy-3-glu equiv/mL) > chokeberry and bilberry > purple carrot and grape > radish and elderberry (GI 50 > 100 microg of cy-3-glu equiv/mL). Anthocyanins played a major role in AREs' chemoprotection and exerted an additive interaction with the other phenolics present. Statistical analyses suggested that anthocyanin chemical structure affected chemoprotection, with nonacylated monoglycosylated anthocyanins having greater inhibitory effect on HT-29 cell proliferation, whereas anthocyanins with pelargonidin, triglycoside, and/or acylation with cinnamic acid exerted the least effect. These findings should be considered for crop selection and the development of anthocyanin-rich functional foods.
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Chou, T.-C., & Talalay, P. (1984) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(84)90007-4 · Cited by 7,178
Hertog, M. G. L., Hollman, P. C. H., Katan, M. B., & Kromhout, D. (1993) · Nutrition and Cancer · doi:10.1080/01635589309514267 · Cited by 1,216
Cited by
Anthocyanins: Natural Colorants with Health-Promoting Properties
He, J., & Giusti, M. M. (2010) · Annual Review of Food Science and Technology · doi:10.1146/annurev.food.080708.100754 · Cited by 1,637
Self-citationNatural Polyphenols for Prevention and Treatment of Cancer
Zhou, Y., Zheng, J., Li, Y., Xu, D.-P., Li, S., Chen, Y.-M., & Li, H.-B. (2016) · Nutrients · doi:10.3390/nu8080515 · Cited by 746
Biosynthesis of Anthocyanins and Their Regulation in Colored Grapes
He, F., Mu, L., Yan, G.-L., Liang, N.-N., Pan, Q.-H., Wang, J., Reeves, M. J., & Duan, C.-Q. (2010) · Molecules · doi:10.3390/molecules15129057 · Cited by 615
Tena, N., Martín, J., & Asuero, A. G. (2020) · Antioxidants · doi:10.3390/antiox9050451 · Cited by 512
Health benefits of anthocyanins and molecular mechanisms: Update from recent decade
Li, D., Wang, P., Luo, Y., Zhao, M., & Chen, F. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1030064 · Cited by 489
“Moreover, Jing et al. (2008) used human colon cancer HT29 cell line to compare the anticancer properties of anthocyanins-rich extract from purple corn, chokeberry, bilberry, purple carrot, grape, radish, and elderberry.”
Metadata
- Authors
- Jing, P., Bomser, J. A., Schwartz, S. J., He, J., Magnuson, B. A., & Giusti, M. M.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-09-19
- Volume
- 56
- Issue
- 20
- Pages
- 9391-9398
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2084484561
- Cited by
- 266
- References
- 2
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jing, P., Bomser, J. A., Schwartz, S. J., He, J., Magnuson, B. A., & Giusti, M. M. (2008). Structure−Function Relationships of Anthocyanins from Various Anthocyanin-Rich Extracts on the Inhibition of Colon Cancer Cell Growth. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/jf8005917
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