In vitro and in vivo antioxidant and anti-inflammatory capacities of an antioxidant-rich fruit and berry juice blend. Results of a pilot and randomized, double-blinded, placebo-controlled, crossover study
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This study investigated the in vitro and in vivo antioxidant and anti-inflammatory properties of a juice blend (JB), MonaVie Active, containing a mixture of fruits and berries with known antioxidant activity, including acai, a palm fruit, as the predominant ingredient. The phytochemical antioxidants in the JB are primarily in the form of anthocyanins, predominantly cyanidin 3-rutoside, cyanidin 3-diglycoside, and cyanidin 3-glucoside. The cell-based antioxidant protection of erythrocytes (CAP-e) assay demonstrated that antioxidants in the JB penetrated and protected cells from oxidative damage ( p < 0.001), whereas polymorphonuclear cells showed reduced formation of reactive oxygen species ( p < 0.003) and reduced migration toward three different pro-inflammatory chemoattractants: fmlp ( p < 0.001), leukotriene B4 ( p < 0.05), and IL-8 ( p < 0.03). A randomized, double-blinded, placebo-controlled, crossover trial with 12 healthy subjects examined the JB's antioxidant activity in vivo. Blood samples at baseline, 1 h, and 2 h following consumption of the JB or placebo were tested for antioxidant capacity using several antioxidant assays and the TBARS assay, a measure of lipid peroxidation. A within subject comparison showed an increase in serum antioxidants at 1 h ( p < 0.03) and 2 h ( p < 0.015), as well as inhibition of lipid peroxidation at 2 h ( p < 0.01) postconsumption.
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Of 20 trials reviewed, nine involved measures of post-prandial status, in which berry consumption was shown to significantly decrease postprandial oxidative stress, especially lipid peroxidation.
“Of 20 trials reviewed, nine involved measures of post-prandial status, in which berry consumption was shown to significantly decrease postprandial oxidative stress, especially lipid peroxidation.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [48]
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Berries: emerging impact on cardiovascular health
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“…USA) Decrease in total and LDLcholesterol and total:HDLcholesterol ratio in cranberry versus placebo groups (P < 0.05); no effects on glucose or glycated hemoglobin Jensen et al. (2008)48 Postprandial Randomized, double-blind, placebo-controlled, crossover trial Twelve healthy subjects (mean…”
InfluentialFruit polyphenols, immunity and inflammation
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Boeira, L. S., Cád, S. V., Bezerra, J. A., Benavente, C. T., Neta, M. T. S. L., Sandes, R. D. D., & Narain, N. (2023) · Journal of Food Science · doi:10.1111/1750-3841.16429 · Cited by 5 · see citing works
- Authors
- Jensen, G. S., Wu, X., Patterson, K. M., Barnes, J., Carter, S. G., Scherwitz, L., Beaman, R., Endres, J. R., & Schauss, A. G.
- Affiliations
- Arkansas Children's Nutrition Center (US)
- Corresponding author
- Jensen, Gitte S.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-08-22
- Volume
- 56
- Issue
- 18
- Pages
- 8326-8333
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2108200538
- Cited by
- 245
- References
- 26
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 3 · 2023: 8 · 2022: 13 · 2021: 15 · 2020: 12 · 2019: 14 · 2018: 7 · 2017: 11 · 2016: 18 · 2015: 18 · 2014: 20 · 2013: 20 · 2012: 29
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- açaí, anthocyanins, cyanidin glycosides, antioxidant activity, anti-inflammatory activity, reactive oxygen species, neutrophil chemotaxis, lipid peroxidation, serum antioxidants
- MeSH terms
- Adult, Anthocyanins, Anti-Inflammatory Agents, Antioxidants, Beverages, Double-Blind Method, Fruit, Humans, Middle Aged, Neutrophils, Pilot Projects, Placebos, Reactive Oxygen Species, Thiobarbituric Acid Reactive Substances, Cross-Over Studies
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