The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals: Miniperspective
Abstract
Nitrogen heterocycles are among the most significant structural components of pharmaceuticals. Analysis of our database of U.S. FDA approved drugs reveals that 59% of unique small-molecule drugs contain a nitrogen heterocycle. In this review we report on the top 25 most commonly utilized nitrogen heterocycles found in pharmaceuticals. The main part of our analysis is divided into seven sections: (1) three- and four-membered heterocycles, (2) five-, (3) six-, and (4) seven- and eight-membered heterocycles, as well as (5) fused, (6) bridged bicyclic, and (7) macrocyclic nitrogen heterocycles. Each section reveals the top nitrogen heterocyclic structures and their relative impact for that ring type. For the most commonly used nitrogen heterocycles, we report detailed substitution patterns, highlight common architectural cores, and discuss unusual or rare structures.
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Predicting reaction performance in C–N cross-coupling using machine learning
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U.S. FDA Approved Drugs from 2015–June 2020: A Perspective
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The importance of synthetic chemistry in the pharmaceutical industry
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Photoexcitation of flavoenzymes enables a stereoselective radical cyclization
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A Survey of the Structures of US FDA Approved Combination Drugs
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“Similarly, many well established and commercially available drugs contain a piperazine ring as part of their molecular structures [77].”
BackgroundPractical Alkoxythiocarbonyl Auxiliaries for Iridium(I)‐Catalyzed C−H Alkylation of Azacycles
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A structural analysis of the FDA green book-approved veterinary drugs and roles in human medicine
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Self-citationModular, stereocontrolled C β –H/C α –C activation of alkyl carboxylic acids
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Essential Medicinal Chemistry of Essential Medicines
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Metadata
- Authors
- Vitaku, E., Smith, D. T., & Njardarson, J. T.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-10-07
- Volume
- 57
- Issue
- 24
- Pages
- 10257-10274
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2407040666
- Cited by
- 6,418
- References
- 1
- FWCI
- 154.40
- Type
- journal article
- Language
- en
- Open access
- closed
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