The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Flavonoids for Controlling Starch Digestion: Structural Requirements for Inhibiting Human α-Amylase
Open accessAbstract
In this study we investigated the structural requirements for inhibition of human salivary alpha-amylase by flavonoids. Four flavonols and three flavones, out of the 19 flavonoids tested, exhibited IC50 values less than 100 microM against human salivary alpha-amylase activity. Structure-activity relationships of these inhibitors by computational ligand docking showed that the inhibitory activity of flavonols and flavones depends on (i) hydrogen bonds between the hydroxyl groups of the polyphenol ligands and the catalytic residues of the binding site and (ii) formation of a conjugated pi-system that stabilizes the interaction with the active site. Our findings show that certain naturally occurring flavonoids act as inhibitors of human alpha-amylase, which makes them promising candidates for controlling the digestion of starch and postprandial glycemia.
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Cited by
Impact of Dietary Polyphenols on Carbohydrate Metabolism
Hanhineva, K., Törrönen, R., Bondia-Pons, I., Pekkinen, J., Kolehmainen, M., Mykkänen, H., & Poutanen, K. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11041365 · Cited by 1,157
α-Amylase Inhibitors: A Review of Raw Material and Isolated Compounds from Plant Source
Sales, P. M., Souza, P. M., Simeoni, L. A., Magalhães, P. O., & Silveira, D. (2012) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j35s3k · Cited by 599
Dietary polyphenols modulate starch digestion and glycaemic level: a review
Sun, L., & Miao, M. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1544883 · Cited by 434
Nature and consequences of non-covalent interactions between flavonoids and macronutrients in foods
Bordenave, N., Hamaker, B. R., & Ferruzzi, M. G. (2014) · Food Funct. · doi:10.1039/c3fo60263j · Cited by 431
Yilmazer-Musa, M., Griffith, A. M., Michels, A. J., Schneider, E., & Frei, B. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf301147n · Cited by 411
Metadata
- Authors
- Lo Piparo, E., Scheib, H., Frei, N., Williamson, G., Grigorov, M., & Chou, C. J.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-05-29
- Volume
- 51
- Issue
- 12
- Pages
- 3555-3561
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W1990657948
- Cited by
- 472
- References
- 27
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- green
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- Lo Piparo, E., Scheib, H., Frei, N., Williamson, G., Grigorov, M., & Chou, C. J. (2008). Flavonoids for Controlling Starch Digestion: Structural Requirements for Inhibiting Human α-Amylase. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm800115x
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