Cited by 119Nanoparticle-Based Drug DeliveryCharacterization and Applications of Magnetic NanoparticlesUltrasound and Hyperthermia Applications

Drug releasing nanoplatforms activated by alternating magnetic fields

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Mertz, Damien, Sandre, Olivier, Bégin-Colin, Sylvie·2017·Biochimica et Biophysica Acta (BBA) - General Subjects

Abstract

The use of an alternating magnetic field (AMF) to generate non-invasively and spatially a localized heating from a magnetic nano-mediator has become very popular these last years to develop magnetic hyperthermia (MH) as a promising therapeutic modality already used in the clinics. AMF has become highly attractive this last decade over others radiations, as AMF allows a deeper penetration in the body and a less harmful ionizing effect. In addition to pure MH which induces tumor cell death through local T elevation, this AMF-generated magneto-thermal effect can also be exploited as a relevant external stimulus to trigger a drug release from drug-loaded magnetic nanocarriers, temporally and spatially. This review article is focused especially on this concept of AMF induced drug release, possibly combined with MH. The design of such magnetically responsive drug delivery nanoplatforms requires two key and complementary components: a magnetic mediator which collects and turns the magnetic energy into local heat, and a thermoresponsive carrier ensuring thermo-induced drug release, as a consequence of magnetic stimulus. A wide panel of magnetic nanomaterials/chemistries and processes are currently developed to achieve such nanoplatforms. This review article presents a broad overview about the fundamental concepts of drug releasing nanoplatforms activated by AMF, their formulations, and their efficiency in vitro and in vivo. This article is part of a Special Issue entitled "Recent Advances in Bionanomaterials" Guest Editors: Dr. Marie-Louise Saboungi and Dr. Samuel D. Bader.

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Crossref · 10.1016/j.bbagen.2017.02.025

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  • AMF's role as a promising therapeutic modality that raises the localized temperature and consequently releases the loaded drug in a spatiotemporal manner has attracted significant scientific attention.

    “In recent years, AMF’s role as a promising therapeutic modality that raises the localized temperature and consequently releases the loaded drug in a spatiotemporal manner has attracted significant scientific attention.192”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [192]

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Authors
Mertz, D., Sandre, O., & Bégin-Colin, S.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Mertz, Damien
Venue
Biochimica et Biophysica Acta (BBA) - General Subjects
Publisher
Elsevier BV
Published
2017-06
Volume
1861
Issue
6
Pages
1617-1641
ISSN
0304-4165 (ISSN-L)
OpenAlex
W2589842643
Cited by
119
References
230
Citations by year
2026: 5 · 2025: 10 · 2024: 11 · 2023: 15 · 2022: 8 · 2021: 13 · 2020: 15 · 2019: 25 · 2018: 14 · 2017: 3
FWCI
1.13
Type
journal article
Language
en
Open access
Locations
  • Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, cc-by-nc)
Funders
  • Université de Strasbourg (IDEX-209i-W14RAT41)
  • European Cooperation in Science and Technology (TD1402)
  • Agence Nationale de la Recherche (ANR-13-BS08-0017 MagnetoChemoBlast)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
  • Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
Keywords
alternating magnetic field, magnetic hyperthermia, drug release, magnetic nanocarriers, magnetic nanoparticles, drug delivery nanoplatform, stimuli-responsive drug delivery
MeSH terms
Animals, Antineoplastic Agents, Drug Carriers, Drug Compounding, Energy Transfer, Humans, Hyperthermia, Induced, Kinetics, Magnetics, Neoplasms, Solubility, Nanomedicine, Nanoparticles, Magnetic Fields, Drug Liberation

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