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Cited by 2,176

The DOI matches its Crossref record.

Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization

Loftsson, Thorsteinn, Brewster, Marcus E.·1996·Journal of Pharmaceutical Sciences
DOI 10.1021/js950534b
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Abstract

Cyclodextrins are cyclic oligosaccharides which have recently been recognized as useful pharmaceutical excipients. The molecular structure of these glucose derivatives, which approximates a truncated cone or torus, generates a hydrophilic exterior surface and a nonpolar cavity interior. As such, cyclodextrins can interact with appropriately sized molecules to result in the formation of inclusion complexes. These noncovalent complexes offer a variety of physicochemical advantages over the unmanipulated drugs including the possibility for increased water solubility and solution stability. Further, chemical modification to the parent cyclodextrin can result in an increase in the extent of drug complexation and interaction. In this short review, the effects of substitution on various cyclodextrin properties and the forces involved in the drug-cyclodextrin complex formation are discussed. Some general observations are made predicting drug solubilization by cyclodextrins. In addition, methods which are useful in the optimization of complexation efficacy are reviewed. Finally, the stabilizing/destabilizing effects of cyclodextrins on chemically labile drugs are evaluated.

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Metadata

Authors
Loftsson, T., & Brewster, M. E.
Venue
Journal of Pharmaceutical Sciences
Publisher
American Geophysical Union (AGU)
Published
1996-10
Volume
85
Issue
10
Pages
1017-1025
ISSN
0022-3549 (ISSN-L)
DOI
10.1021/js950534b
OpenAlex
W2046017608
Cited by
2,176
References
0
FWCI
32.94
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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