Efficacy of polyurethane graft on cyclodextrin to control drug release for tumor treatment
Abstract
Hydrophilicity of cyclodextrin is controlled through grafting of polyurethane of varying graft density, thereby maintain the hydrophilic-hydrophobic balance, to sustain the drug delivery rate for better tumor treatment. Grafting is verified through nuclear magnetic resonance (1 H NMR) and other spectroscopic techniques along with the hydrodynamic volume measurement of grafted species and the degree of substitution has been calculated from the integrated peak areas. Thermal and mechanical stability of the graft copolymers have improved significantly with respect to cyclodextrin and the formation of smaller blobs having larger in number has been obtained from small angle neutron scattering, atomic force microscopy and optical images. Sustained drug delivery has been achieved using graft copolymer as opposed to burst release in pure cyclodextrin and polyurethane and the phenomenon is understood from the specific interactions, as observed though spectroscopic and thermal measurement, between graft copolymer and drug followed by this novel architecture of the graft copolymers. Biocompatibility of graft copolymers has been checked using cellular studies through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and cell adhesion. Importantly, the cell killing efficiency has been demonstrated by embedding anti-cancer drug in polymer matrices causing mortality rate of 80% using graft copolymer against meagre 20% using pure drug or drug embedded in cyclodextrin and the result is realised from the sustained release of drug from the graft copolymer vis-à-vis burst release in other systems. Cellular studies have been translated into an animal model showing the efficacy of newly developed patch, made of drug embedded in copolymer, towards the significant suppression of tumors in mice as compared to control. Histopathological images and biochemical parameters indicate the normal body organ/blood in copolymer treated mice against severely damaged organ especially liver/blood in the mice treated with pure drug or drug embedded in cyclodextrin arising from burst release. Thus, graft copolymer with unique architecture is found to be an effective drug delivery vehicle for melanoma cancer treatment without side effect.
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Minimal side effects upon treatment were revealed from histopathological images of vital organs.
“Minimal side effects upon treatment were revealed from histopathological images of vital organ (Fig. 8c).”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [255]
Treatment of mice bearing melanoma with developed patches of drug-loaded graft copolymers showed significant tumor suppression compared to the pure drug, where slight suppression was noticed arising from burst release.
“Treatment of mice bearing melanoma with developed patches of drug-loaded graft copolymers showed significant tumor suppression compared to the effect of the pure drug, where slight suppression was noticed arising from its burst release.”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [255]
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Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
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Self-citation
- Authors
- Shukla, A., Singh, A. P., Ray, B., Aswal, V., Kar, A. G., & Maiti, P.
- Affiliations
- Indian Institute of Technology BHU (IN)
- Banaras Hindu University (IN)
- Bhabha Atomic Research Centre (IN)
- Corresponding author
- Maiti, Pralay
- Venue
- Journal of Colloid and Interface Science
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 534
- Pages
- 215-227
- ISSN
- 0021-9797 (ISSN-L)
- OpenAlex
- W2892372272
- Cited by
- 40
- References
- 49
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 9 · 2018: 1
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Colloid and Interface Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- UGC, New Delhi, India
- Science and Engineering Research Board (R&D/SERB/LT/SMST/16/17/06)
- Council for Scientific and Industrial Research (02(0074)/12/EMR-II)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- cyclodextrins, sustained drug release, burst release, tumor targeting, melanoma, drug carriers, biocompatibility, patch formulation, antitumor efficacy, degree of substitution, drug-polymer interactions, cytotoxicity
- MeSH terms
- Animals, Antineoplastic Agents, Cyclodextrins, Drug Carriers, HeLa Cells, Humans, Male, Melanoma, Polyurethanes, Mice, Hydrophobic and Hydrophilic Interactions, Drug Liberation
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