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Biocompatibility of Gold Nanoparticles and Their Endocytotic Fate Inside the Cellular Compartment: A Microscopic Overview
Open accessAbstract
Macrophages are one of the principal immune effector cells that play essential roles as secretory, phagocytic, and antigen-presenting cells in the immune system. In this study, we address the issue of cytotoxicity and immunogenic effects of gold nanoparticles on RAW264.7 macrophage cells. The cytotoxicity of gold nanoparticles has been correlated with a detailed study of their endocytotic uptake using various microscopy tools such as atomic force microscopy (AFM), confocal-laser-scanning microscopy (CFLSM), and transmission electron microscopy (TEM). Our findings suggest that Au(0) nanoparticles are not cytotoxic, reduce the production of reactive oxygen and nitrite species, and do not elicit secretion of proinflammatory cytokines TNF-alpha and IL1-beta, making them suitable candidates for nanomedicine. AFM measurements suggest that gold nanoparticles are internalized inside the cell via a mechanism involving pinocytosis, while CFLSM and TEM studies indicate their internalization in lysosomal bodies arranged in perinuclear fashion. Our studies thus underline the noncytotoxic, nonimmunogenic, and biocompatible properties of gold nanoparticles with the potential for application in nanoimmunology, nanomedicine, and nanobiotechnology.
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Variation of the Fluorescence Decay Time of a Molecule in Front of a Mirror
Drexhage, K. H., Kuhn, H., & Schäfer, F. P. (1968) · Berichte der Bunsengesellschaft für physikalische Chemie · doi:10.1002/bbpc.19680720261 · Cited by 260
Lymphatic Uptake of Pulmonary Delivered Radiolabelled Solid Lipid Nanoparticles
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Hossen, S., Hossain, M. K., Basher, M. K., Mia, M. N. H., Rahman, M. T., & Uddin, M. J. (2019) · Journal of Advanced Research · doi:10.1016/j.jare.2018.06.005 · Cited by 998
Recent Progress in Cancer Thermal Therapy Using Gold Nanoparticles
Abadeer, N. S., & Murphy, C. J. (2016) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.5b11232 · Cited by 919
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Metadata
- Authors
- Shukla, R., Bansal, V., Chaudhary, M., Basu, A., Bhonde, R. R., & Sastry, M.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-09-27
- Volume
- 21
- Issue
- 23
- Pages
- 10644-10654
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W2026494961
- Cited by
- 1,687
- References
- 3
- FWCI
- 16.65
- Type
- journal article
- Language
- en
- Open access
- green
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