Three-Dimensional Biodegradable Structures Fabricated by Two-Photon Polymerization
Abstract
Two-photon polymerization has been employed to fabricate three-dimensional structures using the biodegradable triblock copolymer poly(epsilon-caprolactone-co-trimethylenecarbonate)-b-poly(ethylene glycol)-b-poly(epsilon-caprolactone-co-trimethylenecarbonate) with 4,4'-bis(diethylamino)benzophenone as the photoinitiator. The fabricated structures were of good quality and had four micron resolution. Initial cytotoxicity tests show that the material does not affect cell proliferation. These studies demonstrate the potential of two-photon polymerization as a technology for the fabrication of biodegradable scaffolds for tissue engineering.
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Several research groups have investigated the potential of 2PP for biomedical applications with biocompatible resins such as PLA, PCL, PEG or the use of proteins as scaffold material, which have the potential for clinical application.
“Several research groups have been investigated the potential of 2PP for biomedical applications with biocompatible resins such as PLA [28], PCL [29], PEG [30] or the use of proteins as scaffold material [31,32], which have the potential for clinical application [33].”
From <i>In vitro</i> degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization (2016) · cites this paper as [29]
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- Authors
- Claeyssens, F., Hasan, E. A., Gaidukeviciute, A., Achilleos, D. S., Ranella, A., Reinhardt, C., Ovsianikov, A., Shizhou, X., Fotakis, C., Vamvakaki, M., Chichkov, B. N., & Farsari, M.
- Affiliations
- University of Crete (GR)
- Engineering Materials Department, Biomaterials and Tissue Engineering Group, Kroto Research Institute, University of Sheffield, Broad Lane, Sheffield, S3 7HQ, United Kingdom, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, United Kingdom, Institute of Electronic Structure and Laser (IESL), Foundation for Research and Technology Hellas (FORTH), P.O. Box 1527, 711 10 Heraklion, Crete, Greece, Department of Materials Science and Technology and Department of Physics, University of Crete...
- Corresponding author
- Claeyssens, Frederik
- Farsari, Maria
- ORCID
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-02-03
- Volume
- 25
- Issue
- 5
- Pages
- 3219-3223
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W1985571499
- Cited by
- 187
- References
- 34
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 4 · 2023: 9 · 2022: 9 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 11 · 2017: 12 · 2016: 7 · 2015: 11 · 2014: 20 · 2013: 17 · 2012: 18
- FWCI
- 10.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Langmuir (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Engineering and Physical Sciences Research Council (EP/C532066/1)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nonlinear Optical Materials Studies
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- two-photon polymerization, biodegradable polymers, three-dimensional structure, triblock copolymers, photoinitiators, cytotoxicity, biodegradable scaffolds, tissue engineering
- MeSH terms
- Animals, Biocompatible Materials, Biodegradation, Environmental, Equipment Design, Light, Mice, Inbred BALB C, Models, Chemical, Photochemistry, Polymers, Surface Properties, Photons, Tissue Engineering, NIH 3T3 Cells, Cell Proliferation, Mice
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