The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Intracellular Drug Delivery by Poly(lactic-co-glycolic acid) Nanoparticles, Revisited
Open accessAbstract
We reexamined the cellular drug delivery mechanism by poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) to determine their utility and limitations as an intracellular drug delivery system. First, we prepared PLGA NPs which physically encapsulated Nile red (a hydrophobic fluorescent dye), in accordance with the usual procedure for labeling PLGA NPs, incubated them with mesothelial cells, and observed an increase in the intracellular fluorescence. We then prepared NPs from PLGA chemically conjugated to a fluorescent dye and observed their uptake by the mesothelial cells using confocal microscopy. We also used coherent anti-Stokes Raman scattering (CARS) microscopy to image cellular uptake of unlabeled PLGA NPs. Results of this study coherently suggest that PLGA NPs (i) are not readily taken up by cells, but (ii) deliver the payload to cells by extracellular drug release and/or direct drug transfer to contacting cells, which are contrasted with the prevalent view. From this alternative standpoint, we analyzed cytotoxicities of doxorubicin and paclitaxel delivered by PLGA NPs and compared with those of free drugs. Finally, we revisit previous findings in the literature and discuss potential strategies to achieve efficient drug delivery to the target tissues using PLGA NPs.
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Cites
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The Mechanism of Uptake of Biodegradable Microparticles in Caco-2 Cells Is Size Dependent
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Self-citationHigh affinity binding of paclitaxel to human serum albumin
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Cited by
Current Strategies for Brain Drug Delivery
Dong, X. (2018) · Theranostics · doi:10.7150/thno.21254 · Cited by 954
“However, some studies suggested that nanoparticles may not be internalized by cells and the enhanced drug uptake in the brain is non-specific [29, 42, 43].”
BackgroundSelf-Cross-Linked Polymer Nanogels: A Versatile Nanoscopic Drug Delivery Platform
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Polydopamine-Based Simple and Versatile Surface Modification of Polymeric Nano Drug Carriers
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Self-citationIn vitro and in vivo characterization of pharmaceutical nanocarriers used for drug delivery
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Self-citationPark, J., Pei, Y., Hyun, H., Castanares, M. A., Collins, D. S., & Yeo, Y. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.10.037 · Cited by 29
Self-citationDevelopment of Quinic Acid-Conjugated Nanoparticles as a Drug Carrier to Solid Tumors
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Self-citationLiu, H.-J., Wang, M., Wang, Y., Shi, S., Hu, X., Zhang, D.-B., Fan, D., Mintzer, J., & Xu, P. (2025) · Cell Biomaterials · doi:10.1016/j.celbio.2025.100158 · Cited by 13
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Metadata
- Authors
- Xu, P., Gullotti, E., Tong, L., Highley, C. B., Errabelli, D. R., Hasan, T., Cheng, J.-X., Kohane, D. S., & Yeo, Y.
- Venue
- Molecular Pharmaceutics
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-11-26
- Volume
- 6
- Issue
- 1
- Pages
- 190-201
- ISSN
- 1543-8384 (ISSN-L)
- 1543-8392
- OpenAlex
- W2019234680
- Cited by
- 234
- References
- 4
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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