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High Sensitivity of In Vivo Detection of Gold Nanorods Using a Laser Optoacoustic Imaging System
Abstract
The development of a contrast agent for a laser optoacoustic imaging system (LOIS) can significantly widen preclinical and clinical applications of this imaging modality for early detection of cancerous tumors. Gold nanorods were engineered to enhance the contrast for optoacoustic imaging. Under in vivo conditions, 25 microL of gold nanorods solution at a concentration of 1.25 pM were injected into nude mice and detected using a single-channel acoustic transducer. LOIS was used to visualize the distribution of gold nanoparticles at a concentration of 125 pM in vivo when 100 microL of solution of gold nanoparticles was delivered subcutaneously. Our results suggest that LOIS can be used for in vivo detection of gold nanorods at low concentrations and the nanoparticles can be engineered to enhance the diagnostic power of optoacoustic imaging.
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Cited by
Gold Nanorods: From Synthesis and Properties to Biological and Biomedical Applications
Huang, X., Neretina, S., & El‐Sayed, M. A. (2009) · Advanced Materials · doi:10.1002/adma.200802789 · Cited by 1,921
Going deeper than microscopy: the optical imaging frontier in biology
Ntziachristos, V. (2010) · Nature Methods · doi:10.1038/nmeth.1483 · Cited by 1,896
Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents
Kim, J.-W., Galanzha, E. I., Shashkov, E. V., Moon, H.-M., & Zharov, V. P. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.231 · Cited by 710
Ultrahigh Sensitivity Carbon Nanotube Agents for Photoacoustic Molecular Imaging in Living Mice
Zerda, A. D. L., Liu, Z., Bodapati, S., Teed, R., Vaithilingam, S., Khuri-Yakub, B. T., Chen, X., Dai, H., & Gambhir, S. S. (2010) · Nano Letters · doi:10.1021/nl100890d · Cited by 396
Whole-body three-dimensional optoacoustic tomography system for small animals
Brecht, H.-P. F., Su, R., Fronheiser, M. P., Ermilov, S. A., Conjusteau, A., & Oraevsky, A. A. (2009) · Journal of Biomedical Optics · doi:10.1117/1.3259361 · Cited by 304
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Metadata
- Authors
- Eghtedari, M., Oraevsky, A., Copland, J. A., Kotov, N. A., Conjusteau, A., & Motamedi, M.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-06-15
- Volume
- 7
- Issue
- 7
- Pages
- 1914-1918
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2135856533
- Cited by
- 374
- References
- 0
- FWCI
- 25.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Eghtedari, M., Oraevsky, A., Copland, J. A., Kotov, N. A., Conjusteau, A., & Motamedi, M. (2007). High Sensitivity of In Vivo Detection of Gold Nanorods Using a Laser Optoacoustic Imaging System. Nano Letters. https://doi.org/10.1021/nl070557d
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