The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Targeted Gold Nanoparticles Enable Molecular CT Imaging of Cancer
Open accessAbstract
X-ray based computed tomography (CT) is among the most convenient imaging/diagnostic tools in hospitals today in terms of availability, efficiency, and cost. However, in contrast to magnetic resonance imaging (MRI) and various nuclear medicine imaging modalities, CT is not considered a molecular imaging modality since targeted and molecularly specific contrast agents have not yet been developed. Here we describe a targeted molecular imaging platform that enables, for the first time, cancer detection at the cellular and molecular level with standard clinical CT. The method is based on gold nanoprobes that selectively and sensitively target tumor selective antigens while inducing distinct contrast in CT imaging (increased X-ray attenuation). We present an in vitro proof of principle demonstration for head and neck cancer, showing that the attenuation coefficient for the molecularly targeted cells is over 5 times higher than for identical but untargeted cancer cells or for normal cells. We expect this novel imaging tool to lead to significant improvements in cancer therapy due to earlier detection, accurate staging, and microtumor identification.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold Nanorods
Huang, X., El-Sayed, I. H., Qian, W., & El-Sayed, M. A. (2006) · Journal of the American Chemical Society · doi:10.1021/ja057254a · Cited by 5,436
Preparation and Growth Mechanism of Gold Nanorods (NRs) Using Seed-Mediated Growth Method
Nikoobakht, B., & El-Sayed, M. A. (2003) · Chemistry of Materials · doi:10.1021/cm020732l · Cited by 5,069
Gold Nanoparticles Are Taken Up by Human Cells but Do Not Cause Acute Cytotoxicity
Connor, E. E., Mwamuka, J., Gole, A., Murphy, C. J., & Wyatt, M. D. (2005) · Small · doi:10.1002/smll.200400093 · Cited by 2,406
Huang, X., Jain, P. K., El-Sayed, I. H., & El-Sayed, M. A. (2007) · Nanomedicine · doi:10.2217/17435889.2.5.681 · Cited by 1,503
種結晶を媒介とした成長法を用いた金ナノロッド(NR)の調製と成長メカニズム
Nikoobakht, B., & El-Sayed, M. A. (2003) · Chemistry of Materials · Cited by 1,419
Gold nanoparticles: a new X-ray contrast agent
Hainfeld, J. F., Slatkin, D. N., Focella, T. M., & Smilowitz, H. M. (2006) · The British Journal of Radiology · doi:10.1259/bjr/13169882 · Cited by 1,351
Near-Infrared Resonant Nanoshells for Combined Optical Imaging and Photothermal Cancer Therapy
Gobin, A. M., Lee, M. H., Halas, N. J., James, W. D., Drezek, R. A., & West, J. L. (2007) · Nano Letters · doi:10.1021/nl070610y · Cited by 1,314
Au nanoparticles target cancer
Jain, P. K., El-Sayed, I. H., & El-Sayed, M. A. (2007) · Nano Today · doi:10.1016/s1748-0132(07)70016-6 · Cited by 1,157
An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles
Rabin, O., Manuel Perez, J., Grimm, J., Wojtkiewicz, G., & Weissleder, R. (2006) · Nature Materials · doi:10.1038/nmat1571 · Cited by 942
Kim, D., Park, S., Lee, J. H., Jeong, Y. Y., & Jon, S. (2007) · Journal of the American Chemical Society · doi:10.1021/ja071471p · Cited by 876
Carvalho, A. L., Nishimoto, I. N., Califano, J. A., & Kowalski, L. P. (2005) · International Journal of Cancer · doi:10.1002/ijc.20740 · Cited by 867
Hauck, T. S., Ghazani, A. A., & Chan, W. C. W. (2008) · Small · doi:10.1002/smll.200700217 · Cited by 692
Alric, C., Taleb, J., Le Duc, G., Mandon, C., Billotey, C., Le Meur-Herland, A., Brochard, T., Vocanson, F., Janier, M., Perriat, P., et al. (2008) · Journal of the American Chemical Society · doi:10.1021/ja078176p · Cited by 541
Huang, X., El-Sayed, I. H., Qian, W., & El-Sayed, M. A. (2007) · Nano Letters · doi:10.1021/nl070472c · Cited by 518
Kattumuri, V., Katti, K., Bhaskaran, S., Boote, E. J., Casteel, S. W., Fent, G. M., Robertson, D. J., Chandrasekhar, M., Kannan, R., & Katti, K. V. (2007) · Small · doi:10.1002/smll.200600427 · Cited by 380
In Vivo MRI Detection of Gliomas by Chlorotoxin‐Conjugated Superparamagnetic Nanoprobes
Sun, C., Veiseh, O., Gunn, J., Fang, C., Hansen, S., Lee, D., Sze, R., Ellenbogen, R. G., Olson, J., & Zhang, M. (2008) · Small · doi:10.1002/smll.200700784 · Cited by 329
Brain cancer diagnosis and therapy with nanoplatforms☆
KOO, Y., REDDY, G., BHOJANI, M., SCHNEIDER, R., PHILBERT, M., REHEMTULLA, A., ROSS, B., & KOPELMAN, R. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.012 · Cited by 326
Self-citationColloidal Gold Nanoparticles as a Blood-Pool Contrast Agent for X-ray Computed Tomography in Mice
Cai, Q.-Y., Kim, S. H., Choi, K. S., Kim, S. Y., Byun, S. J., Kim, K. W., Park, S. H., Juhng, S. K., & Yoon, K.-H. (2007) · Investigative Radiology · doi:10.1097/rli.0b013e31811ecdcd · Cited by 301
Head and neck cancer: past, present and future
Chin, D., Boyle, G. M., Porceddu, S., Theile, D. R., Parsons, P. G., & Coman, W. B. (2006) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.6.7.1111 · Cited by 255
Kopelman, R., Lee Koo, Y.-E., Philbert, M., Moffat, B. A., Ramachandra Reddy, G., McConville, P., Hall, D. E., Chenevert, T. L., Bhojani, M. S., Buck, S. M., et al. (2005) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2005.02.061 · Cited by 193
Self-citationDiagaradjane, P., Orenstein-Cardona, J. M., E. Colón-Casasnovas, N., Deorukhkar, A., Shentu, S., Kuno, N., Schwartz, D. L., Gelovani, J. G., & Krishnan, S. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1958 · Cited by 181
Photoacoustic imaging of early inflammatory response using gold nanorods
Kim, K., Huang, S.-W., Ashkenazi, S., O’Donnell, M., Agarwal, A., Kotov, N. A., Denny, M. F., & Kaplan, M. J. (2007) · Applied Physics Letters · doi:10.1063/1.2743752 · Cited by 159
Self-citationKimmel, K. A., & Carey, T. E. (1986) · PubMed · Cited by 141
Self-citationWaes, C. V., Kozarsky, K., Warren, A., Kidd, L., Paugh, D., Liebert, M., & Carey, T. E. (1991) · PubMed · Cited by 130
Self-citationGallium-68 PET: a new frontier in receptor cancer imaging.
AL-NAHHAS, A. M., Win, Z. T., Szyszko, T. A., Singh, A., Nanni, C., Fanti, S., & Rubello, D. (2007) · PubMed · Cited by 127
Chamberland, D. L., Agarwal, A., Kotov, N. A., Fowlkes, J. B., Carson, P. L., & Wang, X. (2008) · Nanotechnology · doi:10.1088/0957-4484/19/9/095101 · Cited by 115
Self-citationYoshida, M., Roh, K., & Lahann, J. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.01.048 · Cited by 87
Cited by
Synthesis, Functionalization, and Biomedical Applications of Multifunctional Magnetic Nanoparticles
Hao, R., Xing, R., Xu, Z., Hou, Y., Gao, S., & Sun, S. (2010) · Advanced Materials · doi:10.1002/adma.201000260 · Cited by 1,372
Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Xia, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,162
Recent Progress in Cancer Thermal Therapy Using Gold Nanoparticles
Abadeer, N. S., & Murphy, C. J. (2016) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.5b11232 · Cited by 919
SERS Nanoparticles in Medicine: From Label-Free Detection to Spectroscopic Tagging
Lane, L. A., Qian, X., & Nie, S. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00265 · Cited by 873
Yang, R., Xu, J., Xu, L., Sun, X., Chen, Q., Zhao, Y., Peng, R., & Liu, Z. (2018) · ACS Nano · doi:10.1021/acsnano.7b09041 · Cited by 698
Metadata
- Authors
- Popovtzer, R., Agrawal, A., Kotov, N. A., Popovtzer, A., Balter, J., Carey, T. E., & Kopelman, R.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-11-05
- Volume
- 8
- Issue
- 12
- Pages
- 4593-4596
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2012394652
- Cited by
- 801
- References
- 27
- FWCI
- 21.32
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
