The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
In Vivo MRI Detection of Gliomas by Chlorotoxin‐Conjugated Superparamagnetic Nanoprobes
Open accessAbstract
Converging advances in the development of nanoparticle‐based imaging probes and improved understanding of the molecular biology of brain tumors offer the potential to provide physicians with new tools for the diagnosis and treatment of these deadly diseases. However, the effectiveness of promising nanoparticle technologies is currently limited by insufficient accumulation of these contrast agents within tumors. Here a biocompatible nanoprobe composed of a poly(ethylene glycol) (PEG) coated iron oxide nanoparticle that is capable of specifically targeting glioma tumors via the surface‐bound targeting peptide, chlorotoxin (CTX), is presented. The preferential accumulation of the nanoprobe within gliomas and subsequent magnetic resonance imaging (MRI) contrast enhancement are demonstrated in vitro in 9L cells and in vivo in tumors of a xenograft mouse model. TEM imaging reveals that the nanoprobes are internalized into the cytoplasm of 9L cells and histological analysis of selected tissues indicates that there are no acute toxic effects of these nanoprobes. High targeting specificity and benign biological response establish this nanoprobe as a potential platform to aid in the diagnosis and treatment of gliomas and other tumors of neuroectodermal origin.
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Cites
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Self-citationPrimary brain tumours in adults
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Cited by
Superparamagnetic iron oxide nanoparticles: from preparations to in vivo MRI applications
Qiao, R., Yang, C., & Gao, M. (2009) · Journal of Materials Chemistry · doi:10.1039/b902394a · Cited by 685
Fundamentals and application of magnetic particles in cell isolation and enrichment: a review
Plouffe, B. D., Murthy, S. K., & Lewis, L. H. (2015) · Reports on Progress in Physics · doi:10.1088/0034-4885/78/1/016601 · Cited by 334
Huang, J., Li, Y., Orza, A., Lu, Q., Guo, P., Wang, L., Yang, L., & Mao, H. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201504185 · Cited by 292
Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations
Jasmin, Souza, G. T., Andrade Louzada, R., Rosado-de-Castro, P. H., Mendez-Otero, R., & Carvalho, A. C. C. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s126530 · Cited by 78
Surface functionalized magnetic nanoparticles for targeted cancer therapy and diagnosis
Saifullah, S., Ali, I., Kawish, M., El-Shabasy, R. M., Chen, L., & El-Seedi, H. R. (2020) · Metal Nanoparticles for Drug Delivery and Diagnostic Applications · doi:10.1016/b978-0-12-816960-5.00012-4 · Cited by 13
Metadata
- Authors
- Sun, C., Veiseh, O., Gunn, J., Fang, C., Hansen, S., Lee, D., Sze, R., Ellenbogen, R. G., Olson, J., & Zhang, M.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2008-02-26
- Volume
- 4
- Issue
- 3
- Pages
- 372-379
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W1992034168
- Cited by
- 329
- References
- 33
- FWCI
- 22.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Sun, C., Veiseh, O., Gunn, J., Fang, C., Hansen, S., Lee, D., Sze, R., Ellenbogen, R. G., Olson, J., & Zhang, M. (2008). In Vivo MRI Detection of Gliomas by Chlorotoxin‐Conjugated Superparamagnetic Nanoprobes. Small. https://doi.org/10.1002/smll.200700784
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