Stimulus responsive nanogels for drug delivery
Abstract
Stimulus responsive nanogels are polymeric nanoparticles which are capable of responding to external stimuli by changing their physico-chemical properties, such as volume, water content, refractive index, permeability, and hydrophilicity–hydrophobicity. Compared with other polymer nanoparticles used for drug delivery, stimulus responsive nanogels are noted for their ability to encapsulate bioactive drugs, their high stability for prolonged circulation in the blood stream, and their controlled release and site-specific targeting of loaded drugs modulated by environment stimuli. Particularly, the application of stimulus responsive nanogels provides an interesting opportunity for drug delivery in which the delivery system becomes an active participant, rather than a passive carrier, in the optimization of disease therapy. In this article, the authors review the recent developments in the preparation and application in drug delivery of stimulus responsive nanogels which can respond to small temperature and pH changes, light, magnetic field, biomolecule recognition (specifically glucose responsive nanogels for insulin delivery), and multi-responsive nanogels. The limitations and future improvements of stimulus responsive nanogels are also discussed.
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Thermo-responsive polymers show sol-gel transitions with a change in external temperature, and hydrogels made of thermoresponsive polymers find drug delivery applications through simple chemical modifications.
“Thermo-responsive polymers show sol-gel transitions with a change in temperature of the external environment and hydrogels made of thermoresponsive polymers find tremendous drug delivery applications through simple chemical modifications [29,30,31,32]”
From Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application (2019) · cites this paper as [29]
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- Authors
- Zha, L., Banik, B., & Alexis, F.
- Affiliations
- Donghua University (CN)
- Clemson University (US)
- Corresponding author
- Zha, Liusheng
- Alexis, Frank
- Venue
- Soft Matter
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2011
- Volume
- 7
- Issue
- 13
- Pages
- 5908
- ISSN
- 1744-683X (ISSN-L)
- 1744-6848
- OpenAlex
- W2013984845
- Cited by
- 391
- References
- 135
- Citations by year
- 2026: 5 · 2025: 16 · 2024: 25 · 2023: 24 · 2022: 20 · 2021: 20 · 2020: 21 · 2019: 49 · 2018: 30 · 2017: 27 · 2016: 32 · 2015: 21 · 2014: 24 · 2013: 37 · 2012: 27
- FWCI
- 13.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Soft Matter (publishedVersion)
- Funders
- Clemson University
- National Natural Science Foundation of China
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- drug delivery, polymeric nanoparticles, controlled release, pH-responsive nanogels, insulin delivery, blood circulation stability
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