Cited by 391Nanoparticle-Based Drug DeliveryHydrogels: synthesis, properties, applicationsAdvanced Drug Delivery Systems

Stimulus responsive nanogels for drug delivery

Zha, Liusheng, Banik, Brittany, Alexis, Frank·2011·Soft Matter

Abstract

Stimulus responsive nanogels are polymeric nanoparticles which are capable of responding to external stimuli by changing their physico-chemical properties, such as volume, water content, refractive index, permeability, and hydrophilicity–hydrophobicity. Compared with other polymer nanoparticles used for drug delivery, stimulus responsive nanogels are noted for their ability to encapsulate bioactive drugs, their high stability for prolonged circulation in the blood stream, and their controlled release and site-specific targeting of loaded drugs modulated by environment stimuli. Particularly, the application of stimulus responsive nanogels provides an interesting opportunity for drug delivery in which the delivery system becomes an active participant, rather than a passive carrier, in the optimization of disease therapy. In this article, the authors review the recent developments in the preparation and application in drug delivery of stimulus responsive nanogels which can respond to small temperature and pH changes, light, magnetic field, biomolecule recognition (specifically glucose responsive nanogels for insulin delivery), and multi-responsive nanogels. The limitations and future improvements of stimulus responsive nanogels are also discussed.

Integrity signals

Registry

Crossref · 10.1039/c0sm01307b

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135 of 135 references verified0 citation errors · 0 not checkable

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  • Thermo-responsive polymers show sol-gel transitions with a change in external temperature, and hydrogels made of thermoresponsive polymers find drug delivery applications through simple chemical modifications.

    “Thermo-responsive polymers show sol-gel transitions with a change in temperature of the external environment and hydrogels made of thermoresponsive polymers find tremendous drug delivery applications through simple chemical modifications [29,30,31,32]”

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Authors
Zha, L., Banik, B., & Alexis, F.
Affiliations
  • Donghua University (CN)
  • Clemson University (US)
Corresponding author
  • Zha, Liusheng
  • Alexis, Frank
Venue
Soft Matter
Published
2011
Volume
7
Issue
13
Pages
5908
ISSN
  • 1744-683X (ISSN-L)
  • 1744-6848
OpenAlex
W2013984845
Cited by
391
References
135
Citations by year
2026: 5 · 2025: 16 · 2024: 25 · 2023: 24 · 2022: 20 · 2021: 20 · 2020: 21 · 2019: 49 · 2018: 30 · 2017: 27 · 2016: 32 · 2015: 21 · 2014: 24 · 2013: 37 · 2012: 27
FWCI
13.21
Type
journal article
Language
en
Open access
closed
Locations
Soft Matter (publishedVersion)
Funders
  • Clemson University
  • National Natural Science Foundation of China
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
drug delivery, polymeric nanoparticles, controlled release, pH-responsive nanogels, insulin delivery, blood circulation stability

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