The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Multifunctional Nanoemulsion Platform for Imaging Guided Therapy Evaluated in Experimental Cancer
Open accessAbstract
Nanoparticle applications in medicine have seen a tremendous growth in the past decade. In addition to their drug targeting application and their ability to improve bioavailability of drugs, nanoparticles can be designed to allow their detection with a variety of imaging methodologies. In the current study, we developed a multimodal nanoparticle platform to enable imaging guided therapy, which was evaluated in a colon cancer mouse model. This "theranostic" platform is based on oil-in-water nanoemulsions and carries iron oxide nanocrystals for MRI, the fluorescent dye Cy7 for NIRF imaging, and the hydrophobic glucocorticoid prednisolone acetate valerate (PAV) for therapeutic purposes. Angiogenesis-targeted nanoemulsions functionalized with αvβ(3)-specific RGD peptides were evaluated, as well. When subcutaneous tumors were palpable, the nanoemulsions were administered at a dose of 30 mg of FeO/kg and 10 mg of PAV/kg. MRI and NIRF imaging showed significant nanoparticle accumulation in the tumors, while tumor growth profiles revealed a potent inhibitory effect in all of the PAV nanoemulsion-treated animals as compared to the ones treated with control nanoemulsions, the free drug, or saline. This study demonstrated that our nanoemulsions, when loaded with PAV, iron oxide nanocrystals, and Cy7, represent a flexible and unique theranostic nanoparticle platform that can be applied for imaging guided therapy of cancer.
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Cites
Factors affecting the clearance and biodistribution of polymeric nanoparticles
Alexis, F., Pridgen, E., Molnar, L. K., & Farokhzad, O. C. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800051m · Cited by 3,699
In vivo imaging of siRNA delivery and silencing in tumors
Medarova, Z., Pham, W., Farrar, C., Petkova, V., & Moore, A. (2007) · Nature Medicine · doi:10.1038/nm1486 · Cited by 697
Banciu, M., Metselaar, J. M., Schiffelers, R. M., & Storm, G. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.05.004 · Cited by 63
Self-citation
Cited by
Ulbrich, K., Holá, K., Šubr, V., Bakandritsos, A., Tuček, J., & Zbořil, R. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00589 · Cited by 1,730
Nanoemulsions: Formation, properties and applications
Gupta, A., Eral, H. B., Hatton, T. A., & Doyle, P. S. (2016) · Soft Matter · doi:10.1039/c5sm02958a · Cited by 1,633
Nanomaterials for Theranostics: Recent Advances and Future Challenges
Lim, E.-K., Kim, T., Paik, S., Haam, S., Huh, Y.-M., & Lee, K. (2015) · Chemical Reviews · doi:10.1021/cr300213b · Cited by 1,233
Fabrication and Applications of Microfluidic Devices: A Review
Niculescu, A.-G., Chircov, C., Bîrcă, A. C., & Grumezescu, A. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042011 · Cited by 678
Applications and potential toxicity of magnetic iron oxide nanoparticles
Liu, G., Gao, J., Ai, H., & Chen, X. (2013) · Small · doi:10.1002/smll.201201531 · Cited by 570
Metadata
- Authors
- Gianella, A., Jarzyna, P. A., Mani, V., Ramachandran, S., Calcagno, C., Tang, J., Kann, B., Dijk, W. J. R., Thijssen, V. L., Griffioen, A. W., Storm, G., Fayad, Z. A., & Mulder, W. J. M.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-05-25
- Volume
- 5
- Issue
- 6
- Pages
- 4422-4433
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2168052283
- Cited by
- 212
- References
- 3
- FWCI
- 9.01
- Type
- journal article
- Language
- en
- Open access
- green
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