The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Water-Soluble Superparamagnetic Magnetite Nanoparticles with Biocompatible Coating for Enhanced Magnetic Resonance Imaging
Abstract
Ultrasmall superparamagnetic Fe(3)O(4) nanoparticles (USIRONs) were synthesized by a novel, easily scalable chemical reduction of colloidal iron hydroxide under hydrothermal conditions. The average crystallite size (5.1 ± 0.5 nm) and good crystallinity of the samples were supported by HR-TEM analysis and the saturation magnetization value (47 emu g(-1)). Vitamin C, used as a chemical reducing agent, also served as a capping agent in the oxidized form (dehydroascorbic acid, DHAA) to impart nanoparticles with exceptional solubility and stability in water, PBS buffer, and cell culture medium. Detailed physicochemical analysis of the USIRON suspensions provided insight into the magnetic ordering phenomena within the colloid, arising from the formation of uniform clusters displaying a hydrodynamic size of 41 nm. Phantom experiments on the contrast agent (clinical 3 T MRI scanner) revealed an enhanced r(2)/r(1) ratio of 36.4 (r(1)= 5 s(-1) mM(-1) and r(2)= 182 s(-1) mM(-1)) when compared to the clinically approved agents. The potential of the DHAA-Fe(3)O(4) nanoparticles as negative contrast agents for MRI with optimal hydrodynamic size for extended blood circulation times was confirmed by strong contrast observed in T(2)- and T(2)*-weighted images. The cell tests performed with primary human immune-competent cells confirmed the excellent biocompatibility of USIRONs.
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Cites
Laurent, S., Forge, D., Port, M., Roch, A., Robic, C., Vander Elst, L., & Muller, R. N. (2008) · Chemical Reviews · doi:10.1021/cr068445e · Cited by 6,852
Ultra-large-scale syntheses of monodisperse nanocrystals
Park, J., An, K., Hwang, Y., Park, J.-G., Noh, H.-J., Kim, J.-Y., Park, J.-H., Hwang, N.-M., & Hyeon, T. (2004) · Nature Materials · doi:10.1038/nmat1251 · Cited by 4,076
Tromsdorf, U. I., Bruns, O. T., Salmen, S. C., Beisiegel, U., & Weller, H. (2009) · Nano Letters · doi:10.1021/nl902715v · Cited by 396
Cited by
Wu, W., Wu, Z., Yu, T., Jiang, C., & Kim, W.-S. (2015) · Science and Technology of Advanced Materials · doi:10.1088/1468-6996/16/2/023501 · Cited by 1,574
Kandasamy, G., & Maity, D. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.10.058 · Cited by 422
Liu, Q., Zhong, L.-B., Zhao, Q.-B., Frear, C., & Zheng, Y.-M. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b04598 · Cited by 316
Sodipo, B. K., & Aziz, A. A. (2016) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2016.05.019 · Cited by 169
Metadata
- Authors
- Xiao, L., Li, J., Brougham, D. F., Fox, E. K., Feliu, N., Bushmelev, A., Schmidt, A., Mertens, N., Kiessling, F., Valldor, M., Fadeel, B., & Mathur, S.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-08-02
- Volume
- 5
- Issue
- 8
- Pages
- 6315-6324
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W1980804712
- Cited by
- 282
- References
- 3
- FWCI
- 12.95
- Type
- journal article
- Language
- en
- Open access
- closed
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