The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Preventing Protein Adsorption and Macrophage Uptake of Gold Nanoparticles via a Hydrophobic Shield
Open accessAbstract
Polyethylene glycol (PEG) surface coatings are widely used to render stealth properties to nanoparticles in biological applications. There is abundant literature on the benefits of PEG coatings and their ability to reduce protein adsorption, to diminish nonspecific interactions with cells, and to improve pharmacokinetics, but very little discussion of the limitations of PEG coatings. Here, we show that physiological concentrations of cysteine and cystine can displace methoxy-PEG-thiol molecules from the gold nanoparticle (GNP) surface that leads to protein adsorption and cell uptake in macrophages within 24 h. Furthermore, we address this problem by incorporating an alkyl linker between the PEG and the thiol moieties that provides a hydrophobic shield layer between the gold surface and the hydrophilic outer PEG layer. The mPEG-alkyl-thiol coating greatly reduces protein adsorption on GNPs and their macrophage uptake. This has important implications for the design of GNP for biological systems.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Renal clearance of quantum dots
Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476
Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
Knop, K., Hoogenboom, R., Fischer, D., & Schubert, U. S. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200902672 · Cited by 3,533
Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake
Walkey, C. D., Olsen, J. B., Guo, H., Emili, A., & Chan, W. C. W. (2012) · Journal of the American Chemical Society · doi:10.1021/ja2084338 · Cited by 1,926
Walkey, C. D., & Chan, W. C. W. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15233e · Cited by 1,758
Time Evolution of the Nanoparticle Protein Corona
Casals, E., Pfaller, T., Duschl, A., Oostingh, G. J., & Puntes, V. (2010) · ACS Nano · doi:10.1021/nn901372t · Cited by 1,211
Cited by
Nanoparticle colloidal stability in cell culture media and impact on cellular interactions
Moore, T. L., Rodriguez-Lorenzo, L., Hirsch, V., Balog, S., Urban, D., Jud, C., Rothen-Rutishauser, B., Lattuada, M., & Petri-Fink, A. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00487f · Cited by 1,082
Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery
Li, Y., Maciel, D., Rodrigues, J., Shi, X., & Tomás, H. (2015) · Chemical Reviews · doi:10.1021/cr500131f · Cited by 478
Surface Functionalization of Gold Nanoparticles with Red Blood Cell Membranes
Gao, W., Hu, C. J., Fang, R. H., Luk, B. T., Su, J., & Zhang, L. (2013) · Advanced Materials · doi:10.1002/adma.201300638 · Cited by 465
Recent advances and future prospects of iron oxide nanoparticles in biomedicine and diagnostics
Vallabani, N. V. S., & Singh, S. (2018) · 3 Biotech · doi:10.1007/s13205-018-1286-z · Cited by 322
Effects of engineered nanoparticles on the innate immune system
Liu, Y., Hardie, J., Zhang, X., & Rotello, V. M. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.09.011 · Cited by 315
Huang, J., Li, Y., Orza, A., Lu, Q., Guo, P., Wang, L., Yang, L., & Mao, H. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201504185 · Cited by 292
Wang, L., Li, J., Pan, J., Jiang, X., Ji, Y., Li, Y., Qu, Y., Zhao, Y., Wu, X., & Chen, C. (2013) · Journal of the American Chemical Society · doi:10.1021/ja406924v · Cited by 287
Ho, Y. T., Kamm, R. D., & Kah, J. C. Y. (2018) · Nanoscale · doi:10.1039/c8nr02393j · Cited by 102
Metadata
- Authors
- Larson, T. A., Joshi, P. P., & Sokolov, K.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-09-25
- Volume
- 6
- Issue
- 10
- Pages
- 9182-9190
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2038282755
- Cited by
- 217
- References
- 5
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
