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Cited by 454

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Cyclic RGD-Linked Polymeric Micelles for Targeted Delivery of Platinum Anticancer Drugs to Glioblastoma through the Blood–Brain Tumor Barrier

Miura, Yutaka, Takenaka, Tomoya, Toh, Kazuko, Wu, Shourong, Nishihara, Hiroshi, Kano, Mitsunobu R., Ino, Yasushi, Nomoto, Takahiro, Matsumoto, Yu, Koyama, Hiroyuki, Cabral, Horacio, Nishiyama, Nobuhiro, Kataoka, Kazunori·2013·ACS Nano
DOI 10.1021/nn402662d
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Abstract

Ligand-mediated drug delivery systems have enormous potential for improving the efficacy of cancer treatment. In particular, Arg-Gly-Asp peptides are promising ligand molecules for targeting αvβ3/αvβ5 integrins, which are overexpressed in angiogenic sites and tumors, such as intractable human glioblastoma (U87MG). We here achieved highly efficient drug delivery to U87MG tumors by using a platinum anticancer drug-incorporating polymeric micelle (PM) with cyclic Arg-Gly-Asp (cRGD) ligand molecules. Intravital confocal laser scanning microscopy revealed that the cRGD-linked polymeric micelles (cRGD/m) accumulated rapidly and had high permeability from vessels into the tumor parenchyma compared with the PM having nontargeted ligand, "cyclic-Arg-Ala-Asp" (cRAD). As both cRGD/m- and cRAD-linked polymeric micelles have similar characteristics, including their size, surface charge, and the amount of incorporated drugs, it is likely that the selective and accelerated accumulation of cRGD/m into tumors occurred via an active internalization pathway, possibly transcytosis, thereby producing significant antitumor effects in an orthotopic mouse model of U87MG human glioblastoma.

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Metadata

Authors
Miura, Y., Takenaka, T., Toh, K., Wu, S., Nishihara, H., Kano, M. R., Ino, Y., Nomoto, T., Matsumoto, Y., Koyama, H., Cabral, H., Nishiyama, N., & Kataoka, K.
Venue
ACS Nano
Publisher
American Chemical Society (ACS)
Published
2013-09-18
Volume
7
Issue
10
Pages
8583-8592
ISSN
  • 1936-0851 (ISSN-L)
  • 1936-086X
DOI
10.1021/nn402662d
OpenAlex
W2001257757
Cited by
454
References
49
FWCI
14.02
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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