The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Exceptionally High Payload of Doxorubicin in Hollow Gold Nanospheres for Near-Infrared Light-Triggered Drug Release
Open accessAbstract
We report dual-functional hollow gold nanospheres (HAuNS, approximately 40-nm diameter) capable of mediating both photothermal ablation of cancer cells and drug release upon near-infrared (NIR) light irradiation. As high as 63% DOX by weight ( approximately 1.7 microg DOX/microg Au) could be loaded to polyethylene glycol (PEG)-coated HAuNS since DOX was coated to both the outer and the inner surfaces of HAuNS. Irradiation with NIR laser induced photothermal conversion, which triggered rapid DOX release from DOX-loaded HAuNS. The release of DOX was also pH-dependent, with more DOX released in aqueous solution at lower pH. Significantly greater cell killing was observed when MDA-MB-231 cells incubated with DOX-loaded HAuNS were irradiated with NIR light, attributable to both HAuNS-mediated photothermal ablation and cytotoxicity of released free DOX.
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Cites
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710
Nanostructures in Biodiagnostics
Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603
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Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Xia, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,162
Flexible electronics based on inorganic nanowires
Liu, Z., Xu, J., Chen, D., & Shen, G. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00116h · Cited by 512
Song, J., Zhou, J., & Duan, H. (2012) · Journal of the American Chemical Society · doi:10.1021/ja305154a · Cited by 438
Stimuli‐responsive nanotherapeutics for precision drug delivery and cancer therapy
Qiao, Y., Wan, J., Zhou, L., Ma, W., Yang, Y., Luo, W., Yu, Z., & Wang, H. (2019) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1527 · Cited by 332
Target Delivery and Cell Imaging Using Hyaluronic Acid-Functionalized Graphene Quantum Dots
Abdullah-Al-Nahain, Lee, J.-E., In, I., Lee, H., Lee, K. D., Jeong, J. H., & Park, S. Y. (2013) · Molecular Pharmaceutics · doi:10.1021/mp400219u · Cited by 258
Metadata
- Authors
- You, J., Zhang, G., & Li, C.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-02-01
- Volume
- 4
- Issue
- 2
- Pages
- 1033-1041
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2062322931
- Cited by
- 597
- References
- 2
- FWCI
- 22.94
- Type
- journal article
- Language
- en
- Open access
- green
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