Stimuli‐responsive nanotherapeutics for precision drug delivery and cancer therapy
Abstract
Cancer remains one of the world's leading causes of death. However, most conventional chemotherapeutic drugs only show a narrow therapeutic window in patients because of their inability to discriminate cancer cells from healthy cells. Nanoparticle‐based therapeutics (termed nanotherapeutics) have emerged as potential solutions to mitigate many obstacles posed by these free drugs. Deep insights into knowledge of the tumor microenvironment and materials science make it possible to construct nanotherapeutics that are able to release cargoes in response to a variety of internal stimuli and external triggers. Therefore, such highly sophisticated nanosystems could help impede the premature release of toxic drugs in the blood circulation or healthy tissues, thus enhancing the safety profiles of encapsulated drugs. In this context, this review offers a comprehensive overview of several specific stimuli, including internal stimuli (e.g., pH, temperature, enzyme, redox, and H 2 O 2 ) and external stimuli (e.g., magnetic, photo, and ultrasound). We envision that applications of these smart nanotherapeutics can benefit cancer patients and provide a good chance for clinical translation of many nanoparticle formulas. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools > Diagnostic Nanodevices Diagnostic Tools > in vitro Nanoparticle‐Based Sensing
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pH-sensitive linkers allow the conjugation of drugs and polymers through pH-dependent conformational changes to intelligently deliver the therapeutic agent in the desired location and avoid systematic toxicity.
“The pH-sensitive linkers allow the conjugation of drugs and polymers through pH-dependent conformational changes to intelligently deliver the therapeutic agent in the desired location and avoid systematic toxicity.140”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [140]
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Engineering precision nanoparticles for drug delivery
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- Authors
- Qiao, Y., Wan, J., Zhou, L., Ma, W., Yang, Y., Luo, W., Yu, Z., & Wang, H.
- Affiliations
- First Affiliated Hospital Zhejiang University (CN)
- Southern Medical University (CN)
- Corresponding author
- Wang, Hangxiang
- Venue
- WIREs Nanomedicine and Nanobiotechnology
- Publisher
- Wiley
- Published
- 2018-05-04
- Volume
- 11
- Issue
- 1
- Pages
- e1527-e1527
- ISSN
- 1939-0041 (ISSN-L)
- 1939-5116
- OpenAlex
- W2802665335
- Cited by
- 332
- References
- 186
- Citations by year
- 2026: 22 · 2025: 31 · 2024: 39 · 2023: 49 · 2022: 44 · 2021: 54 · 2020: 63 · 2019: 21 · 2018: 9
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81571799, 81773193)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- nanoparticle drug delivery, cancer therapy, targeted drug release, tumor microenvironment, pH-responsive nanoparticles, temperature-responsive nanoparticles, enzyme-responsive nanoparticles, redox-responsive nanoparticles, magnetic stimuli, photothermal therapy, ultrasound-triggered drug release, clinical translation
- MeSH terms
- Animals, Humans, Neoplasms, Oxidation-Reduction, Drug Delivery Systems, Reactive Oxygen Species, Nanoparticles, Tumor Microenvironment
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