The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Exceptionally High Payload of Doxorubicin in Hollow Gold Nanospheres for Near-Infrared Light-Triggered Drug Release
Open accessAbstract
We report dual-functional hollow gold nanospheres (HAuNS, approximately 40-nm diameter) capable of mediating both photothermal ablation of cancer cells and drug release upon near-infrared (NIR) light irradiation. As high as 63% DOX by weight ( approximately 1.7 microg DOX/microg Au) could be loaded to polyethylene glycol (PEG)-coated HAuNS since DOX was coated to both the outer and the inner surfaces of HAuNS. Irradiation with NIR laser induced photothermal conversion, which triggered rapid DOX release from DOX-loaded HAuNS. The release of DOX was also pH-dependent, with more DOX released in aqueous solution at lower pH. Significantly greater cell killing was observed when MDA-MB-231 cells incubated with DOX-loaded HAuNS were irradiated with NIR light, attributable to both HAuNS-mediated photothermal ablation and cytotoxicity of released free DOX.
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Metadata
- Authors
- You, J., Zhang, G., & Li, C.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-02-01
- Volume
- 4
- Issue
- 2
- Pages
- 1033-1041
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2062322931
- Cited by
- 597
- References
- 3
- FWCI
- 22.94
- Type
- journal article
- Language
- en
- Open access
- green
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