Ecdysteroids of Vitex scabra Stem Bark
Abstract
Two new ecdysteroids, 24-epi-pinnatasterone (1) and scabrasterone (2), together with 11 known ecdysteroids, calonysterone, pterosterone, 24-epi-makisterone A, 20-hydroxyecdysone (3), polypodine B, ajugasterone C, pinnatasterone (4), 11alpha-hydroxyecdysone, 24-epi-abutasterone, 20,26-dihydroxyecdysone, and turkesterone (5), were isolated from the stem bark of Vitex scabra. This plant species contained a very high concentration (1.8%) of 3 and thus provided a good source of this parent ecdysteroid and related rare ecdysteroids. Compounds 1 and 2 exhibited very low moulting activity in the Musca bioassay. The low biological activity of these two ecdysteroids was in agreement with those of other 22-deoxyecdysteroids.
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Turkesterone is found in some endemic plants, such as Ajuga turkestanica, Rhaponticum carthamoides, Triticum aestivum, and Vitex scabra.
“It is found in some endemic plants, such as A. turkestanica, R. carthamoides, Triticum aestivum L., Vitex scabra, etc. [13,69,216,217,218].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [218]
Compounds 175 and 176 exhibited very low moulting hormone activity in the Musca bioassay.
“Evaluated Musca assay for moulting hormone activity and exhibited very low activity.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [124]
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- Authors
- Suksamrarn, A., Kumpun, S., & Yingyongnarongkul, B.-E.
- Affiliations
- Ramkhamhaeng University (TH)
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-09-05
- Volume
- 65
- Issue
- 11
- Pages
- 1690-1692
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2337120619
- Cited by
- 41
- References
- 14
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2013: 1 · 2012: 12
- FWCI
- 0.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Natural Products (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive Natural Diterpenoids Research
- Keywords
- ecdysteroids, stem bark, 20-hydroxyecdysone, natural product isolation
- MeSH terms
- Acetylation, Chromatography, Thin Layer, Plants, Medicinal, Thailand, Molecular Structure, Plant Stems, Nuclear Magnetic Resonance, Biomolecular, Vitex, Plant Bark, Ecdysteroids, Musa
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