Lucentamycins A−D, Cytotoxic Peptides from the Marine-Derived Actinomycete Nocardiopsis lucentensis
Abstract
Four new 3-methyl-4-ethylideneproline-containing peptides, lucentamycins A-D (1-4), have been isolated from the fermentation broth of a marine-derived actinomycete identified by phylogenetic methods as Nocardiopsis lucentensis (strain CNR-712). The planar structures of the new compounds were assigned on the basis of 1D and 2D NMR spectroscopic techniques, while the absolute configurations of the amino acid residues were determined by application of the advanced Marfey method. Lucentamycins A (1) and B (2) showed significant in vitro cytotoxicity against HCT-116 human colon carcinoma.
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- Authors
- Cho, J. Y., Williams, P. G., Kwon, H. C., Jensen, P. R., & Fenical, W.
- Affiliations
- Scripps Institution of Oceanography (US)
- Corresponding author
- Fenical, William
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-07-14
- Volume
- 70
- Issue
- 8
- Pages
- 1321-1328
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2093734728
- Cited by
- 120
- References
- 10
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 18 · 2021: 11 · 2020: 12 · 2019: 6 · 2018: 9 · 2017: 5 · 2015: 8 · 2014: 5 · 2013: 6 · 2012: 11
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Natural Products (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Korea Science and Engineering Foundation
- Vlaamse regering
- National Cancer Institute (CA44848)
- National Center for Research Resources (S10RR017768)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Keywords
- marine actinomycetes, cytotoxic peptides, absolute configuration, structure elucidation, natural product isolation
- MeSH terms
- Antineoplastic Agents, Bahamas, Drug Screening Assays, Antitumor, Humans, Marine Biology, Oligopeptides, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Actinobacteria, HCT116 Cells
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