Semisynthetic Artemisinin, the Chemical Path to Industrial Production
Abstract
A new commercial-scale alternative manufacturing process to produce a complementary source of artemisinin to supplement the plant-derived supply is described by conversion of biosynthetic artemisinic acid into semisynthetic artemisinin using diastereoselective hydrogenation and photooxidation as pivotal steps. This process was accepted by Prequalification of Medicines Programme (PQP) in 2013 as a first source of nonplant-derived-artemisinin in industrial scale from Sanofi production facility in Garessio, Italy.
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Presently microbial production is at best semi-synthetic, terminating at artemisinic acid (AA), which must then be extracted from culture and chemically converted to artemisinin using photooxidation.
“Presently microbial production is at best semi-synthetic, terminating at artemisinic acid (AA), which must then be extracted from culture and chemically converted to artemisinin using photooxidation (8, 10).”
From <i>Artemisia annua</i> mutant impaired in artemisinin synthesis demonstrates importance of nonenzymatic conversion in terpenoid metabolism (2016) · cites this paper as [10]
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- Authors
- Turconi, J., Griolet, F., Guevel, R., Oddon, G., Villa, R., Geatti, A., Hvala, M., Rossen, K., Göller, R., & Burgard, A.
- Affiliations
- Sanofi (France) (FR)
- Sanofi (Germany) (DE)
- Corresponding author
- Turconi, Joël
- Burgard, Andreas
- Venue
- Organic Process Research & Development
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-03-04
- Volume
- 18
- Issue
- 3
- Pages
- 417-422
- ISSN
- 1083-6160 (ISSN-L)
- 1520-586X
- OpenAlex
- W2329391962
- Semantic Scholar
- 952b71448d1d08a32b9ef27f9cbb91e76d237a8c
- Cited by
- 228
- References
- 18
- Citations by year
- 2026: 14 · 2025: 19 · 2024: 23 · 2023: 19 · 2022: 12 · 2021: 23 · 2020: 24 · 2019: 19 · 2018: 23 · 2017: 14 · 2016: 24 · 2015: 11 · 2014: 3
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Organic Process Research & Development (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical compounds biological activities
- Keywords
- artemisinic acid, diastereoselective hydrogenation, photooxidation, industrial synthesis, antimalarial drugs, Sanofi
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