Cited by 228Sesquiterpenes and Asteraceae StudiesPlant biochemistry and biosynthesisPhytochemical compounds biological activities

Semisynthetic Artemisinin, the Chemical Path to Industrial Production

Turconi, Joël, Griolet, Frédéric, Guevel, Ronan, Oddon, Gilles, Villa, Roberto, Geatti, Andrea, Hvala, Massimo, Rossen, Kai +2 more·2014·Organic Process Research & Development

Abstract

A new commercial-scale alternative manufacturing process to produce a complementary source of artemisinin to supplement the plant-derived supply is described by conversion of biosynthetic artemisinic acid into semisynthetic artemisinin using diastereoselective hydrogenation and photooxidation as pivotal steps. This process was accepted by Prequalification of Medicines Programme (PQP) in 2013 as a first source of nonplant-derived-artemisinin in industrial scale from Sanofi production facility in Garessio, Italy.

Integrity signals

Registry

Crossref · 10.1021/op4003196

Cites

17 of 17 references verified0 citation errors · 0 not checkable

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Claims the paper makes

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Cites

Flagged first, then by citations

1 of the 18 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

  1. World Health Organization, 2012, World Malaria Report
  2. Kopetzki D., 2013, Chem.—Eur. J., 19

Cited by

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Authors
Turconi, J., Griolet, F., Guevel, R., Oddon, G., Villa, R., Geatti, A., Hvala, M., Rossen, K., Göller, R., & Burgard, A.
Affiliations
  • Sanofi (France) (FR)
  • Sanofi (Germany) (DE)
Corresponding author
  • Turconi, Joël
  • Burgard, Andreas
Venue
Organic Process Research & Development
Published
2014-03-04
Volume
18
Issue
3
Pages
417-422
ISSN
  • 1083-6160 (ISSN-L)
  • 1520-586X
OpenAlex
W2329391962
Cited by
228
References
18
Citations by year
2026: 14 · 2025: 19 · 2024: 23 · 2023: 19 · 2022: 12 · 2021: 23 · 2020: 24 · 2019: 19 · 2018: 23 · 2017: 14 · 2016: 24 · 2015: 11 · 2014: 3
FWCI
5.55
Type
journal article
Language
en
Open access
closed
Locations
Organic Process Research & Development (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical compounds biological activities
Keywords
artemisinic acid, diastereoselective hydrogenation, photooxidation, industrial synthesis, antimalarial drugs, Sanofi

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