CoChat
Sign Up
Cited by 168

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Surface Modification of Quartz Inhibits Toxicity, Particle Uptake, and Oxidative DNA Damage in Human Lung Epithelial Cells

Schins, Roel P. F., Duffin, Rodger, Höhr, Doris, Knaapen, Ad M., Shi, Tingming, Weishaupt, Christel, Stone, Vicki, Donaldson, Ken, Borm, Paul J. A.·2002·Chemical Research in Toxicology
DOI 10.1021/tx025558u
Open this paper in CoChat — free account

Abstract

Quartz (crystalline silica) is not consistently carcinogenic across different industries where similar quartz exposure occurs. In addition, there are reports that surface modification of quartz affects its cytotoxicity, inflammogenicity, and fibrogenicity. Taken together, these data suggest that the carcinogenicity of quartz is also related to particle surface characteristics, and so we determined the genotoxic effects of DQ12 quartz particles versus DQ12 whose surface was modified by treating with either aluminum lactate or polyvinylpyridine-N-oxide (PVNO). The different particle preparations were characterized for hydroxyl-radical generation using electron spin resonance (ESR). DNA damage was determined by immunocytochemical analysis of 8-hydroxydeoxyguanosine (8-OHdG) and the alkaline comet-assay using A549 human lung epithelial cells. Cytotoxicity was measured using the LDH- and MTT-assays, and particle uptake by the A549 cells was quantified by light microscopy, using digital light imaging evaluation of 800 nm sections. The ability of quartz to generate hydroxyl-radicals in the presence of hydrogen peroxide was markedly reduced upon surface modification with aluminum lactate or PVNO. DNA strand breakage and 8-OHdG formation, as produced by quartz at nontoxic concentrations, could be completely prevented by both coating materials. Particle uptake into A549 cells appeared to be significantly inhibited by the PVNO-coating, and to a lesser extent by the aluminum-lactate coat…

Overview

Integrity signals

Registry

Crossref · 10.1021/tx025558u

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 65

  1. Cullen M. R., 1990, N. Engl. J. Med., 322, 10.1056/NEJM199003013220905 · DOI
  2. International Agency for Research on Cancer (IARC), 1997, Some Silicates, Coal Dust and Para-aramid Fibrils. Monograph on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, 68
  3. Vallyathan V., 1988, Am. Rev. Respir. Dis., 138, 10.1164/ajrccm/138.5.1213 · DOI · Paper page
  4. Vallyathan V., 1991, J. Toxicol. Environ. Health, 33, 10.1080/15287399109531529 · DOI · Paper page
  5. Fubini B., 1990, Chemical functionalities at the silica surface determining its reactivity when inhaled. Formation and reactivity of surface radicals. Toxicol. Ind. Health 6, 571−598
  6. Fubini B., 1998, The Surface Properties of Silica (Legand, 464
  7. Fubini B., 1998, Surface chemistry and quartz hazard. Ann. Occup. Hyg. 42, 521−530
  8. Kensler T. W., 1984, Role of oxygen radicals in tumor promotion. Environ. Mutagen. 6, 593−616
  9. Trush M. A., 1991, An overview of the relationship between oxidative stress and chemical carcinogenesis. Free Radical Biol. Med. 10, 201−210
  10. Marnett L. J., 2000, Oxyradicals and DNA damage. Carcinogenesis 21, 361−370
  11. Yamano Y., 1995, Oxidative DNA damage induced by silica in vivo. Environ. Res. 69, 102−107
  12. Nehls P., 1997, Formation and persistence of 8-oxoguanine in rat lung cells as an important determinant for tumor formation following particle exposure. Environ. Health Perspect. 105, 1291−1296
  13. Seiler F., 2001, Am. J. Respir. Cell Mol. Biol., 24, 10.1165/ajrcmb.24.4.4181 · DOI · Paper page
  14. Driscoll K. E., 1996, Role of inflammation in the development of rat lung tumors in response to chronic particle exposure. Inhal. Toxicol. 8, 139−153
  15. Driscoll K. E., 1997, Effects of particle exposure and particle-elicited inflammatory cells on mutation in rat alveolar epithelial cells. Carcinogenesis 18, 423−430
  16. Borm P. J. A., 1997, Toxicol. Lett., 88
  17. Greim H., 2001, Germany. Inhal. Toxicol. 13, 737−754.
  18. Johnston C. J., 2000, Pulmonary chemokine and mutagenic responses in rats after subchronic inhalation of amorphous and crystalline silica. Toxicol. Sci. 56, 504−413
  19. Schins R. P. F., 2000, Inhal. Toxicol., 14, 78
  20. Daniel L. N., 1993, Oxidative DNA damage by crystalline silica. Free Radical Biol. Med. 14, 463−472
  21. Hesterberg T. W., 1984, Dependence of asbestos- and mineral dust-induced transformation of mammalian cells in culture on fiber dimension. Cancer Res. 44, 2170−2180
  22. Nagalakshmi R., 1995, Mutat. Res., 335, 33
  23. Zhong B. Z., 1997, Detection of mineral-dust-induced DNA damage in two mammalian cell lines using the alkaline single cell gel/comet assay. Mutat. Res. 393, 181−187
  24. Liu X., 1996, Mutat. Res., 361, 94
  25. Liu X., 1998, Toxicol. Lett. 96−, 97, 84
  26. Schins R. P. F., 2002, Mutat. Res., 517, 86
  27. Fung H., 1997, Patterns of 8-hydroxydeoxyguanosine formation in DNA and indications of oxidative stress in rat and human pleural mesothelial cells after exposure to crocidolite asbestos. Carcinogenesis 18, 825−832, 10.1093/carcin/18.4.825 · DOI
  28. Xu A., 1999, Role of oxyradicals in mutagenicity and DNA damage induced by crocidolite asbestos in mammalian cells. Cancer Res. 59, 5922−5926
  29. Kim, H. N., Morimoto, Y., Tsuda, T., Ootsuyama, Y., Hirohashi, M., Hirano, T., Tanaka, I., Lim, Y., Yun, I. G., and Kasai, H. (2001) Changes in DNA 8-hydroxyguanine levels, 8-hydroxyguanine repair activity, and hOGG1 and hMTH1 mRNA expression in human lung alveolar epithelial cells induced by crocidolite asbestos.Carcinogenesis22, 265−269. · DOI · Paper page
  30. Takeuchi T., 1994, HL60. Carcinogenesis 15, 635−639.
  31. Liu W., 2000, Am. J. Respir. Cell. Mol. Biol., 23
  32. Stalder K., 1965, Hemolytic activity of suspensions of different silica modifications and inert dusts. Nature 207, 874−875
  33. Nash T., 1966, Physico-Chemical properties of silica in relation to ist toxicity. Nature 210, 259−261
  34. Fenoglio I., 2000, Inhal. Toxicol., 12, 89, 10.1080/08958378.2000.11463233 · DOI
  35. Brown G. M., 1989, Toxicol. Appl. Pharmacol., 101, 105, 10.1016/0041-008X(89)90215-9 · DOI
  36. Bégin R., 1987, Sustained efficiacy of aluminum to reduce quartz toxicity in the lung. Exp. Lung Res. 13, 205−222
  37. Dufresne A., 1994, Influence of aluminium treatments on pulmonary retention of quartz in sheep silicosis. Exp. Lung Res. 20, 157−168
  38. Duffin R., 2001, Toxicol. Appl. Pharmacol., 176, 17, 10.1006/taap.2001.9268 · DOI · Paper page
  39. Schlipköter H. W., 1961, Klin. Wschr., 39, 61, 10.1007/BF01532453 · DOI · Paper page
  40. Bégin R., 1986, Aluminum lactate treatment alters the lung biological activity of quartz. Exp. Lung Res. 10, 385−399
  41. Gabor S., 1975, vitro action of quartz on alveolar macrophage lipid peroxides. Arch. Environ. Health 30, 499−501
  42. Van Maanen J. M., 1999, Iron Release, and DNA Damage and Toxicity in Rat Lung Epithelial Cells. Inhal. Toxicol. 11, 1123−1141.
  43. Knaapen A. M., 2000, Ambient particulate matter induces oxidative DNA damage in lung epithelial cells. Inhal. Toxicol. 12, 125−132
  44. Stearns R. C., 2001, Am. J. Respir. Cell Mol. Biol., 24, 10.1165/ajrcmb.24.2.4081 · DOI
  45. Don Porto Carero, A., Hoet, P. H., Verschaeve, L., Schoeters, G., and Nemery, B. (2001) Genotoxic effects of carbon black particles, diesel exhaust particles, and urban air particulates and their extracts on a human alveolar epithelial cell line (A549) and a human monocytic cell line (THP-1).Environ. Mol. Mutagen.3, 155−163. · DOI
  46. Mosmann T., 1983, J. Immunol. Methods, 65, 10.1016/0022-1759(83)90303-4 · DOI · Paper page
  47. Brown, D. M., Wilson, M. R., MacNee, W., Stone, V., and Donaldson, K. (2001) Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines.Toxicol. Appl. Pharmacol.175, 191−199. · DOI
  48. Singh N. P., 1988, A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175, 184−191
  49. Olive P. L., 1990, Radiat. Res., 122, 94, 10.2307/3577587 · DOI
  50. Collins A. R., 1995, Mutat. Res., 336, 77, 10.1016/0921-8777(94)00043-6 · DOI
  51. Schlipkoter H. W., 1970, Investigations on the aetiology of coal workers' pneumoconiosis with the use of PVN-oxide. Inhaled Part. 1, 379−390
  52. Goldstein B., 1987, The prophylactic use of polyvinyl-N-oxide (PVNO) in baboons exposed to quartz dust. Environ. Res. 42, 469−481
  53. Fubini B., 2000, Adsorption on silica surfaces
  54. Gulumian M., 1987, Free radical scavenging properties of polyvinylpyridine N-oxide: a possible mechanism for its action in pneumoconiosis. Med. Lav. 78, 124−128
  55. Dalal N. S., 1990, J. Toxicol. Environ. Health, 29, 10.1080/15287399009531393 · DOI
  56. Tice R. R., 2000, Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 35, 206−221
  57. Lim Y., 1999, Toxicol. Lett., 108
  58. Garrido C., 1997, HSP27 as a mediator of confluence-dependent resistance to cell death induced by anticancer drugs. Cancer Res. 57, 2661−2667
  59. Huang Y., 2000, J. Biol. Chem., 275
  60. Schins R. P. F., 1999, Ann. Occup. Hyg., 43, 33
  61. Wu J., 2000, Am. J. Physiol. Lung Cell Mol. Physiol., 279
  62. Churg A., 1996, Am. J. Respir. Crit. Care Med., 154, 10.1164/ajrccm.154.4.8887617 · DOI
  63. Oberdorster G., 1999, Exp. Lung Res., 25, 6, 10.1080/019021499270385 · DOI
  64. Albrecht C., 2002, Importance of surface characteristics of DQ12 quartz for acute inflammation. Ann. Occup. Hyg. 46 (suppl. 1), 22−26
  65. Abbreviations ROS, reactive oxygen species

Cited by

Sorted by citations

See all 168

Metadata

Authors
Schins, R. P. F., Duffin, R., Höhr, D., Knaapen, A. M., Shi, T., Weishaupt, C., Stone, V., Donaldson, K., & Borm, P. J. A.
Venue
Chemical Research in Toxicology
Publisher
American Chemical Society (ACS)
Published
2002-08-24
Volume
15
Issue
9
Pages
1166-1173
ISSN
  • 0893-228X
  • 1520-5010
DOI
10.1021/tx025558u
Cited by
168
References
5
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review