The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Metabolomics—the link between genotypes and phenotypes
Abstract
Metabolites are the end products of cellular regulatory processes, and their levels can be regarded as the ultimate response of biological systems to genetic or environmental changes. In parallel to the terms 'transcriptome' and proteome', the set of metabolites synthesized by a biological system constitute its 'metabolome'. Yet, unlike other functional genomics approaches, the unbiased simultaneous identification and quantification of plant metabolomes has been largely neglected. Until recently, most analyses were restricted to profiling selected classes of compounds, or to fingerprinting metabolic changes without sufficient analytical resolution to determine metabolite levels and identities individually. As a prerequisite for metabolomic analysis, careful consideration of the methods employed for tissue extraction, sample preparation, data acquisition, and data mining must be taken. In this review, the differences among metabolite target analysis, metabolite profiling, and metabolic fingerprinting are clarified, and terms are defined. Current approaches are examined, and potential applications are summarized with a special emphasis on data mining and mathematical modelling of metabolism.
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“Up to 200,000 different metabolites are estimated to occur in the plant kingdom, and combinations of several hundreds of secondary metabolites generally characterize each edible plant (6,64,65).”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [64]
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Metadata
- Authors
- Fiehn, O.
- Affiliations
- Max Planck Institute of Molecular Plant Physiology (DE)
- Corresponding author
- Fiehn, Oliver
- ORCID
- Fiehn, Oliver
- Venue
- Plant Molecular Biology
- Published
- 2002-01
- Volume
- 48
- Issue
- 1-2
- Pages
- 155-171
- ISSN
- 0167-4412 (ISSN-L)
- 1573-5028
- OpenAlex
- W4294326454
- Cited by
- 3,445
- References
- 110
- Citations by year
- 2026: 153 · 2025: 135 · 2024: 174 · 2023: 151 · 2022: 194 · 2021: 181 · 2020: 201 · 2019: 191 · 2018: 176 · 2017: 178 · 2016: 195 · 2015: 157 · 2014: 157 · 2013: 173 · 2012: 131
- FWCI
- 23.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Plant Molecular Biology (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Keywords
- plant metabolomics, metabolome, genotype-phenotype correlation, metabolite profiling, metabolic fingerprinting, plant tissue extraction, sample preparation, data mining, plant metabolism
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