Evidence for Autonomic Nervous System Imbalance in Women with Irritable Bowel Syndrome

Heitkemper, Margaret; Burr, Robert L.; Jarrett, Monica; Hertig, Vicky; Lustyk, Mary Kathleen; Bond, Eleanor F.

doi:10.1023/a:1018871617483

Cited by 117Gastrointestinal motility and disordersHeart Rate Variability and Autonomic ControlVagus Nerve Stimulation Research

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Evidence for Autonomic Nervous System Imbalance in Women with Irritable Bowel Syndrome

Heitkemper, Margaret, Burr, Robert L., Jarrett, Monica, Hertig, Vicky, Lustyk, Mary Kathleen, Bond, Eleanor F.·1998·Digestive Diseases and Sciences

DOI 10.1023/a:1018871617483

Open this paper in CoChat — free account

Abstract

Autonomic nervous system function was assessed in women with and without irritable bowel syndrome using frequency domain measures of heart rate variability. Women were interviewed and placed into the irritable bowel syndrome (N = 25) group based on history of diagnosis and self-report of current gastrointestinal symptoms. Women in the control group denied a history of chronic gastrointestinal symptoms (N = 15). Women were followed for one menstrual cycle with a symptom diary, and during mid-luteal phase they wore a Holter 24-hr electrocardiograph monitor. Women with irritable bowel syndrome demonstrated significantly lower vagal tone as measured by the high frequency spectrum relative to control women. In addition, women with irritable bowel syndrome had a flattened 24-hr pattern of heart rate variability, with significantly lower levels of vagal tone during sleep. These results suggest that systemic sympathovagal balance may be shifted in a subset of women with irritable bowel syndrome.

Integrity signals

Registry

Crossref · 10.1023/a:1018871617483

Cites

17 of 17 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Nineteen studies compared IBS with HC, 9 compared IBD with HC, and 2 compared HRV across all 3 comparators.
“Nineteen studies compared IBS with HC (31–49), 9 compared IBD with HC (50–58), and 2 compared HRV across all 3 comparators (41,44).”
From Alterations in Heart Rate Variability Associated With Irritable Bowel Syndrome or Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis (2021) · cites this paper as [31]
HF was recorded in all studies, LF was recorded in 26 (96.8%), and VLF was recorded in 6 (21.4%).
“HF was recorded in all studies, LF was recorded in 26 (96.8%) (31–47,50–58), and VLF was recorded in 6 (21.4%) (37,41,44,52,56,57).”
From Alterations in Heart Rate Variability Associated With Irritable Bowel Syndrome or Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis (2021) · cites this paper as [31]
HRV is an objective, noninvasive biomarker that reflects current ANS function correlated with IBS symptoms.
“HRV is an objective, noninvasive biomarker that reflects current ANS function correlated with IBS symptoms.”
From Effects of cognitive behavior therapy on heart rate variability in young females with constipation-predominant irritable bowel syndrome: A parallel-group trial (2017) · cites this paper as [18]

U. S. Householder survey of functional gastrointestinal disorders: Prevalence, sociodemography, and health impact
Drossman, D. A., Li, Z., Andruzzi, E., Temple, R. D., Talley, N. J., Grant Thompson, W., Whitehead, W. E., Janssens, J., Funch-Jensen, P., Corazziari, E., et al. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01303162 · Cited by 2,198
Frequency domain measures of heart period variability and mortality after myocardial infarction
Bigger, J. T., Fleiss, J. L., Steinman, R. C., Rolnitzky, L. M., Kleiger, R. E., & Rottman, J. N. (1992) · Circulation · doi:10.1161/01.cir.85.1.164 · Cited by 1,712
Basic and clinical aspects of visceral hyperalgesia
Mayer, E. A., & Gebhart, G. F. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90086-8 · Cited by 920
A Patient Questionnaire to Identify Bowel Disease
Talley, N. J., Phillips, S. F., Melton, L. J., Wiltgen, C., & Zinsmeister, A. R. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-111-8-671 · Cited by 444
Heart rate variability. Frequency domain analysis.
Őri, Z., Monir, G., Weiss, J., Sayhouni, X., & Singer, D. H. (1992) · PubMed · Cited by 300
Predominant symptoms in irritable bowel syndrome correlate with specific autonomic nervous system abnormalities
Aggarwal, A., Cutts, T. F., Abell, T. L., Cardoso, S., Familoni, B., Bremer, J., & Karas, J. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90753-6 · Cited by 297
Irritable bowel-type symptoms in HMO examinees
Longstreth, G. F., & Wolde-Tsadik, G. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01303163 · Cited by 279
Heart rate variability in healthy subjects is related to age and gender
Jensen‐Urstad, K., Storck, N., BOUVIER, F., Ericson, M. O., LINDBLAND, L. E., & Jensen‐Urstad, M. (1997) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1997.00142.x · Cited by 242
Heart Rate Variability
Őri, Z., Monir, G., Weiss, J., Sayhouni, X., & Singer, D. H. (1992) · Cardiology Clinics · doi:10.1016/s0733-8651(18)30231-5 · Cited by 234
Autonomic Vagal Nerve Dysfunction in Patients with Ulcerative Colitis
Lindgren, S. C., Stewénius, J., Sjölund, K., Lilja, B., & Sundkvist, G. (1993) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529309096103 · Cited by 154
Autonomic dysfunction in gastrointestinal motility disorders
Bharucha, A. E., Camilleri, M., Low, P. A., & Zinsmeister, A. R. (1993) · Gut · doi:10.1136/gut.34.3.397 · Cited by 141
The sympathetic nervous system modulates perception and reflex responses to gut distention in humans
Iovino, P., Azpiroz, F., Domingo, E., & Malagelada, J. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90439-5 · Cited by 135
Increased urine catecholamines and cortisol in women with irritable bowel syndrome.
Heitkemper, M. M., Jarrett, M. E., Cain, K. C., Shaver, J. L. F., Bond, E. F., Woods, N. F., & Walker, E. F. (1996) · PubMed · Cited by 127
Self-citation
NEUROGENIC MUCOUS COLITIS
Bockus, H. L., Bank, J., & Wilkinson, S. A. (1928) · The American Journal of the Medical Sciences · doi:10.1097/00000441-192812000-00006 · Cited by 106
ABNORMAL VAGAL FUNCTION IN IRRITABLE BOWEL SYNDROME
Smart, H. L. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91792-2 · Cited by 99
Effects of gender and age on heart rate variability in healthy individuals and in persons after sudden cardiac arrest
Cowan, M. J., Pike, K. C., & Burr, R. L. (1994) · Journal of Electrocardiology · doi:10.1016/s0022-0736(94)80037-5 · Cited by 68
Self-citation
Autonomic Nervous System Function in Patients with Functional Abdominal Pain an Experimental Study
Jørgensen, L. S., Christiansen, P., Raundahl, U., Østgaard, S. E., Christensen, N. J., Fenger, M., & Flachs, H. (1993) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529309096046 · Cited by 39

Flagged first, then by citations

Research works printed but not linked: 1

Lee KT, Rhee PL, Kim J, Koh KC, Paik SW, Rhee JC, Kim S: Assessment of autonomic tone over a 24-hour period in patients with irritable bowel syndrome. Gastroenterology 112:A773, 1997

Sorted by citations

Systematic review of the comorbidity of irritable bowel syndrome with other disorders: What are the causes and implications?
Whitehead, W. E., Palsson, O., & Jones, K. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32392 · Cited by 1,116
The neurobiology of stress and gastrointestinal disease
MAYER, E. A. (2000) · Gut · doi:10.1136/gut.47.6.861 · Cited by 666
Stress and the gastrointestinal tract
Bhatia, V., & Tandon, R. (2005) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2004.03508.x · Cited by 496
V. Stress and irritable bowel syndrome
Mayer, E. A., Naliboff, B. D., Chang, L., & Coutinho, S. V. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.4.g519 · Cited by 413
Gender differences in irritable bowel syndrome
Chang, L., & Heitkemper, M. M. (2002) · Gastroenterology · doi:10.1053/gast.2002.36603 · Cited by 351
Self-citation
Meta-analytic evidence for decreased heart rate variability in chronic pain implicating parasympathetic nervous system dysregulation
Tracy, L. M., Ioannou, L., Baker, K. S., Gibson, S. J., Georgiou‐Karistianis, N., & Giummarra, M. J. (2015) · Pain · doi:10.1097/j.pain.0000000000000360 · Cited by 330
Evolving pathophysiologic models of functional gastrointestinal disorders
Mayer, E. A., & Collins, S. M. (2002) · Gastroenterology · doi:10.1053/gast.2002.33584 · Cited by 329
Pain in Endometriosis
Maddern, J., Grundy, L., Castro, J., & Brierley, S. M. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.590823 · Cited by 298
The Role of Stress on Physiologic Responses and Clinical Symptoms in Irritable Bowel Syndrome
Chang, L. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.032 · Cited by 281
Central changes associated with chronic pelvic pain and endometriosis
Brawn, J., Morotti, M., Zondervan, K. T., Becker, C. M., & Vincent, K. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu025 · Cited by 274
Somatic comorbidities of irritable bowel syndrome: A systematic analysis
Riedl, A., Schmidtmann, M., Stengel, A., Goebel, M., Wisser, A.-S., Klapp, B. F., & Mönnikes, H. (2008) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2008.02.021 · Cited by 274
Prospective Study of Motor, Sensory, Psychologic, and Autonomic Functions in Patients With Irritable Bowel Syndrome
Camilleri, M., McKinzie, S., Busciglio, I. A., Low, P. A., Sweetser, S. R., Burton, D. D., Baxter, K. L., Ryks, M. D., & Zinsmeister, A. R. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.02.060 · Cited by 244
British Society of Gastroenterology guidelines for the management of the irritable bowel syndrome
Jones, J. R. A., Boorman, J., Cann, P., Forbes, A., Gomborone, J., Heaton, K., Hungin, P., Kumar, D., Libby, G., Spiller, R. E., et al. (2000) · Gut · doi:10.1136/gut.47.suppl_2.ii1 · Cited by 226
Autonomic nervous system dysfunction may explain the multisystem features of fibromyalgia
Martínez‐Lavín, M., & Hermosillo, A. G. (2000) · Seminars in Arthritis and Rheumatism · doi:10.1016/s0049-0172(00)80008-6 · Cited by 226
The relationship between irritable bowel syndrome and psychiatric disorders: from molecular changes to clinical manifestations
Fadgyas-Stanculete, M., Buga, A.-M., Popa-Wagner, A., & Dumitrascu, D. L. (2014) · Journal of Molecular Psychiatry · doi:10.1186/2049-9256-2-4 · Cited by 197
Pathophysiology of endometriosis-associated pain: A review of pelvic and central nervous system mechanisms
Coxon, L., Horne, A. W., & Vincent, K. (2018) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2018.01.014 · Cited by 170
Autonomic nervous system function in women with irritable bowel syndrome
Heitkemper, M., Jarrett, M., Cain, K. C., Burr, R., Levy, R. L., Feld, A., & Hertig, V. (2001) · Digestive Diseases and Sciences · doi:10.1023/a:1010671514618 · Cited by 145
Self-citation
Diarrhea- and constipation-predominant IBS patients differ in postprandial autonomic and cortisol responses
Elsenbruch, S., & Orr, W. C. (2001) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03526.x · Cited by 140
Sleep Disturbance Influences Gastrointestinal Symptoms in Women with Irritable Bowel Syndrome
Jarrett, M. E., Heitkemper, M. M., Cain, K. C., Burr, R. L., & Hertig, V. L. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1005581226265 · Cited by 139
Self-citation
An Initial Report of Sleep Disturbance in Inactive Inflammatory Bowel Disease
Keefer, L., Stepanski, E. J., Ranjbaran, Z., Benson, L. M., & Keshavarzian, A. (2006) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26656 · Cited by 137
Comorbidity of headache and gastrointestinal complaints. The Head-HUNT Study.
Aamodt, A. H., Stovner, L. J., Hagen, K., & Zwart, J.-A. (2008) · PubMed · doi:10.1111/j.1468-2982.2007.01486.x · Cited by 125
Heart rate variability in the irritable bowel syndrome: A review of the literature
Mazurak, N., Seredyuk, N., Sauer, H., Teufel, M., & Enck, P. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01866.x · Cited by 102
Physiological underpinnings of irritable bowel syndrome: neurohormonal mechanisms
Camilleri, M. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.270892 · Cited by 98
Autonomic nervous system dysregulation in irritable bowel syndrome
Salvioli, B., Pellegatta, G., Malacarne, M., Pace, F., Malesci, A., Pagani, M., & Lucini, D. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12512 · Cited by 88
HRV Biofeedback for Pediatric Irritable Bowel Syndrome and Functional Abdominal Pain: A Clinical Replication Series
Stern, M. J., Guiles, R. A. F., & Gevirtz, R. (2014) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-014-9261-x · Cited by 87
Pneumogastric (Vagus) Nerve Activity Indexed by Heart Rate Variability in Chronic Pain Patients Compared to Healthy Controls: A Systematic Review and Meta-Analysis
Koenig, J. (2016) · Pain Physician · doi:10.36076/ppj/2016.19.e55 · Cited by 85
Autonomic regulation of cardiac function during sleep in patients with irritable bowel syndrome
Orr, W. C., Elsenbruch, S., & Harnish, M. J. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.02318.x · Cited by 83
Autonomic cardiovascular responses are impaired in women with irritable bowel syndrome
Waring, W. S., Chui, M., Japp, A., Nicol, E. F., & Ford, M. J. (2004) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000135362.35665.49 · Cited by 83
Autonomic Abnormalities in Children With Functional Abdominal Pain: Coincidence or Etiology?
Chelimsky, G. G., Boyle, J. T., Tusing, L., & Chelimsky, T. C. (2001) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200107000-00008 · Cited by 79
Autonomic functioning during REM sleep differentiates IBS symptom subgroups
Thompson, J. J., Elsenbruch, S., Harnish, M. J., & Orr, W. C. (2002) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.07112.x · Cited by 78
Autonomic Function in Patients with Functional Dyspepsia Assessed by 24-Hour Heart Rate Variability
Lorena, S. L. S., Figueiredo, M. J. D. O., Almeida, J. R. S., & Mesquita, M. A. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1013246900041 · Cited by 71
Autonomic functioning in irritable bowel syndrome measured by heart rate variability: A meta‐analysis
Liu, Q., Wang, E. M., Yan, X. J., & Chen, S. L. (2013) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12092 · Cited by 69
Is there a causal link between psychological disorders and functional gastrointestinal disorders?
Koloski, N. A., Holtmann, G., & Talley, N. J. (2020) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2020.1801414 · Cited by 68
Heart rate variability is related to pain severity and predominant bowel pattern in women with irritable bowel syndrome
Cain, K. C., Jarrett, M. E., Burr, R. L., Hertig, V. L., & Heitkemper, M. M. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00877.x · Cited by 67
Self-citation
Comorbidity of gastrointestinal disorders, migraine, and tension-type headache: a cross-sectional study in Iran
Martami, F., Ghorbani, Z., Abolhasani, M., Togha, M., Meysamie, A., Sharifi, A., & Jahromi, S. R. (2017) · Neurological Sciences · doi:10.1007/s10072-017-3141-0 · Cited by 67
Autonomic nervous system derangement in fibromyalgia syndrome and related disorders.
Cohen, H., Neumann, L., Kotler, M., & Buskila, D. (2001) · PubMed · Cited by 67
Irritable bowel syndrome subtypes differ in body awareness, psychological symptoms and biochemical stress markers
Eriksson, E., Andrén, K. I., Eriksson, H., & Kurlberg, G. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.4889 · Cited by 65
Irritable bowel syndrome and inflammatory bowel disease: interrelated diseases?
Quigley, E. M. M. (2005) · Chinese Journal of Digestive Diseases · doi:10.1111/j.1443-9573.2005.00202.x · Cited by 65
Psychological and Physiological Responses to Postprandial Mental Stress in Women With the Irritable Bowel Syndrome
Elsenbruch, S., Lovallo, W. R., & Orr, W. C. (2001) · Psychosomatic Medicine · doi:10.1097/00006842-200109000-00014 · Cited by 65
A comprehensive study of autonomic dysfunction in the fibromyalgia patients
Kulshreshtha, P., Gupta, R., Yadav, R. K., Bijlani, R. L., & Deepak, K. K. (2011) · Clinical Autonomic Research · doi:10.1007/s10286-011-0150-6 · Cited by 53
Disturbances of Motility and Visceral Hypersensitivity in Irritable Bowel Syndrome: Biological Markers or Epiphenomenon
Quigley, E. M. M. (2005) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2005.02.010 · Cited by 52
Psychological Therapies in Patients with Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Altayar, O., Sharma, V., Prokop, L. J., Sood, A., & Murad, M. H. (2015) · Gastroenterology Research and Practice · doi:10.1155/2015/549308 · Cited by 50
Hypothesis: The Chaos and Complexity Theory May Help our Understanding of Fibromyalgia and Similar Maladies
Martínez‐Lavín, M., Infante, Ó., & Lerma, C. (2007) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2007.04.003 · Cited by 50
Different Autonomic Responses to Experimental Pain in IBS Patients and Healthy Controls
Tousignant‐Laflamme, Y., Goffaux, P., Bourgault, P., & Marchand, S. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000225607.56352.ce · Cited by 49
Autonomic nervous system function during sleep among women with irritable bowel syndrome
Jarrett, M. E., Burr, R. L., Cain, K. C., Rothermel, J. D., Landis, C. A., & Heitkemper, M. M. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-9943-9 · Cited by 46
Self-citation
Subtle involvement of the parasympathetic nervous system in patients with irritable bowel syndrome
van Orshoven, N. P., Andriesse, G. I., van Schelven, L. J., Smout, A. J. P. M., Akkermans, L. M. A., & Oey, P. L. (2006) · Clinical Autonomic Research · doi:10.1007/s10286-006-0307-x · Cited by 46
Current Concepts of the Irritable Bowel Syndrome
Quigley, E. M. M. (2003) · Scandinavian Journal of Gastroenterology · doi:10.1080/00855910310001403 · Cited by 46
Alterations in Heart Rate Variability Associated With Irritable Bowel Syndrome or Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Sadowski, A., Dunlap, C., Lacombe, A., & Hanes, D. (2021) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000275 · Cited by 45
“(31) USA Cross-sectional 25/15 0/0 I IBS-C/D/M Seated/standing/”
BackgroundResultInfluential
Reduced Heart Rate Variability in Patients With Medically Unexplained Physical Symptoms: A Meta-Analysis of HF-HRV and RMSSD
Vreijling, S. R., Troudart, Y., & BROSSCHOT, J. F. (2020) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000874 · Cited by 40
Dissociated autonomic regulation during stress and physical complaints
Papousek, I., Schulter, G., & Premsberger, E. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00298-2 · Cited by 40
Autonomic Nervous System Function in Young Children With Functional Abdominal Pain or Irritable Bowel Syndrome
Jarrett, M., Heitkemper, M., Czyzewski, D., Zeltzer, L., & Shulman, R. J. (2012) · The Journal of Pain · doi:10.1016/j.jpain.2012.02.007 · Cited by 38
Self-citation
Changes in brain G proteins and colonic sympathetic neural signaling in chronic-acute combined stress rat model of irritable bowel syndrome (IBS)
Zou, N., Lv, H., Li, J., Yang, N., Xue, H., Zhu, J., & Qian, J. (2008) · Translational research · doi:10.1016/j.trsl.2008.10.002 · Cited by 38
Sleep-Related Autonomic Disturbances in Symptom Subgroups of Women with Irritable Bowel Syndrome
Robert, J. J. T., Elsenbruch, S., & Orr, W. C. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9305-z · Cited by 38
5-HT and the brain–gut axis: opportunities for pharmacologic intervention
Crowell, M. D., & Wessinger, S. B. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.6.761 · Cited by 36
Effects of cognitive behavior therapy on heart rate variability in young females with constipation-predominant irritable bowel syndrome: A parallel-group trial
Jang, A., Hwang, S.-K., Padhye, N. S., & Meininger, J. C. (2017) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm17017 · Cited by 35
Autonomic imbalance during the day in patients with inflammatory bowel disease in remission. Evidence from spectral analysis of heart rate variability over 24 hours
Mouzas, I., Pallis, A. G., KOCHIADAKIS, G. E., Marketou, M. E., CHLOUVERAKIS, G. I., Melissas, J., Vardas, P. E., & Kouroumalis, E. (2002) · Digestive and Liver Disease · doi:10.1016/s1590-8658(02)80070-6 · Cited by 32
Clinical Implications of Associations between Headache and Gastrointestinal Disorders: A Study Using the Hallym Smart Clinical Data Warehouse
Lee, S., Lee, J.-J., Kwon, Y.-S., Kim, J. H., & Sohn, J. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00526 · Cited by 31
Heart rate variability characteristics of patients with irritable bowel syndrome and associations with symptoms
Polster, A. V., Friberg, P., Gunterberg, V., Öhman, L., Nevé, B. L., Törnblom, H., Cvijović, M., & Simrén, M. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13320 · Cited by 31
Towards an integrative model of irritable bowel syndrome
Naliboff, B. D., Chang, L., Munakata, J., & Mayer, E. A. (2000) · Progress in brain research · doi:10.1016/s0079-6123(08)62154-8 · Cited by 31
Gastrointestinal functioning during sleep: a new horizon in sleep medicine
Orr, W. C. (2001) · Sleep Medicine Reviews · doi:10.1053/smrv.2000.0149 · Cited by 30
Baroreflex mechanisms in irritable bowel syndrome: Part I. Traditional indices
Davydov, D. M., Naliboff, B., Shahabi, L., & Shapiro, D. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.01.042 · Cited by 29
Relationships of abdominal pain, reports to visceral and temperature pain sensitivity, conditioned pain modulation, and heart rate variability in irritable bowel syndrome
Jarrett, M. E., Han, C. J., Cain, K. C., Burr, R. L., Shulman, R. J., Barney, P., Naliboff, B. D., Zia, J., & Heitkemper, M. M. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12812 · Cited by 27
Self-citation
Stress reactivity in childhood functional abdominal pain or irritable bowel syndrome
Gulewitsch, M. D., Weimer, K., Enck, P., Schwille‐Kiuntke, J., Hautzinger, M., & Schlarb, A. A. (2016) · European Journal of Pain · doi:10.1002/ejp.914 · Cited by 26
Mental, Physical, Dietary, and Nutritional Effects on Irritable Bowel Syndrome in Young Japanese Women
Omagari, K., Murayama, T., Tanaka, Y., Yoshikawa, C., Inoue, S.-I., Ichimura‐Shimizu, M., Hatanaka, M., Saimei, M., Muto, K., Tobina, T., et al. (2013) · Internal Medicine · doi:10.2169/internalmedicine.52.0248 · Cited by 26
Disturbances in large bowel motility
Spiller, R. E. (1999) · Best Practice & Research Clinical Gastroenterology · doi:10.1053/bega.1999.0035 · Cited by 24
Autonomic Function at Rest and in Response to Emotional and Rectal Stimuli in Women with Irritable Bowel Syndrome
Spetalen, S., Sandvik, L., Blomhoff, S., & Jacobsen, M. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-0066-0 · Cited by 22
Viscerosensory-cardiovascular reflexes: altered baroreflex sensitivity in irritable bowel syndrome
van der Veek, P. P. J., Swenne, C. A., van de Vooren, H., Schoneveld, A. L., Maestri, R., & Masclee, A. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00607.2004 · Cited by 22
Mind-Body Practices in Integrative Medicine
Walach, H., Ferrari, M.-L. G., Sauer, S., & Kohls, N. (2012) · Religions · doi:10.3390/rel3010050 · Cited by 22
Asymmetries in reciprocal baroreflex mechanisms and chronic pain severity: Focusing on irritable bowel syndrome
Davydov, D. M., Naliboff, B. D., Shahabi, L., & Shapiro, D. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13186 · Cited by 21
The Autonomic Nervous System and Fibromyalgia
Martínez‐Lavín, M. (2002) · Journal of Musculoskeletal Pain · doi:10.1300/j094v10n01_18 · Cited by 20
Evidence for Altered Anorectal Function in Irritable Bowel Syndrome Patients with Sleep Disturbance
Chen, C., Liu, T., Yi, C., & Orr, W. C. (2011) · Digestion · doi:10.1159/000330847 · Cited by 18
Disautonomia: um conceito emergente na síndrome da fibromialgia
Jacomini, L. C. L., & da Silva, N. A. (2007) · Revista Brasileira de Reumatologia · doi:10.1590/s0482-50042007000500010 · Cited by 17
Somatic Manifestations of Traumatic Stress
Mayer, E. A. (2007) · Cambridge University Press eBooks · doi:10.1017/cbo9780511500008.011 · Cited by 15
Consideration of Migraines Among Risk Factors for Postoperative Nausea and Vomiting
Kim, J. H., Lim, M. S., Lee, S., Kwon, Y. S., Lee, J. J., & Sohn, J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103154 · Cited by 14
So-Eum Type as an Independent Risk Factor for Irritable Bowel Syndrome: A Population-Based Study in Korea
Lee, S. K., Yoon, D. W., Yi, H., Lee, S. W., Kim, J. Y., Kim, J., Hong, J. H., & Shin, C. (2014) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2014.0077 · Cited by 14
Examining the Association between Insomnia and Bowel Disorders in Canada: Is there a trend?
Hon, C. (2010) · UBC Faculty of Medicine medical journal · Cited by 13
Women with diarrhoea-predominant irritable bowel syndrome show an increased pressure response to 35% carbon dioxide stress challenge
Shufflebotham, J., Wetherell, M. A., Hince, D., Hood, S. D., Lightman, S. L., Nutt, D., Probert, C. S., & Potokar, J. P. (2008) · Stress · doi:10.1080/10253890801976926 · Cited by 13
Analysis of autonomic function during natural defecation in patients with irritable bowel syndrome using real-time recording with a wearable device
Nakata, R., Tanaka, F., Sugawara, N., Kojima, Y., Takeuchi, T., Shiba, M., Higuchi, K., & Fujiwara, Y. (2022) · PLoS ONE · doi:10.1371/journal.pone.0278922 · Cited by 12
Irritable bowel syndrome
Birrer, R. B. (2002) · Disease-a-Month · doi:10.1016/s0011-5029(02)90015-5 · Cited by 12
Mild Hyperbaric Oxygen Exposure Enhances Peripheral Circulatory Natural Killer Cells in Healthy Young Women
Nisa, B. U., Nakanishi, R., Tanaka, M., Lin, H., Hirabayashi, T., Maeshige, N., Kondo, H., & Fujino, H. (2023) · Life · doi:10.3390/life13020408 · Cited by 11
Gastrointestinal disorders
Mayer, E. A., & Brunnhuber, S. (2012) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52002-9.00036-x · Cited by 11
Irritable bowel syndrome
Sach, J., & Chang, L. (2002) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-002-0049-3 · Cited by 11
The Effect of Korean Hand Acupuncture on Young, Single Korean Students With Irritable Bowel Syndrome
Park, H., & Cha, C. (2012) · Gastroenterology Nursing · doi:10.1097/sga.0b013e318274b1f2 · Cited by 10
Preliminary evidence for increased parasympathetic activity during social inclusion and exclusion in adolescents with functional abdominal pain
Gulewitsch, M. D., Jusyte, A., Mazurak, N., Weimer, K., & Schönenberg, M. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.05.008 · Cited by 10
Sleep and Functional Bowel Disorders: Can Bad Bowels Cause Bad Dreams?
Orr, W. C. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.01996.x · Cited by 10
Heart Rate Variability as a Measure of Disease State in Irritable Bowel Syndrome
Park, H.-J. (2008) · Asian Nursing Research · doi:10.1016/s1976-1317(08)60024-9 · Cited by 8
Bladder Pain Sensitivity Is a Potential Risk Factor for Irritable Bowel Syndrome
Shlobin, A. E., Tu, F. F., Sain, C. R., Kmiecik, M. J., Kantarovich, D., Singh, L., Wang, C. E., & Hellman, K. M. (2023) · Digestive Diseases and Sciences · doi:10.1007/s10620-023-07868-7 · Cited by 8
Frequent Abdominal Pain in Childhood and Youth: A Systematic Review of Psychophysiological Characteristics
Gulewitsch, M. D., Müller, J., Enck, P., Weimer, K., Schwille‐Kiuntke, J., & Schlarb, A. A. (2014) · Gastroenterology Research and Practice · doi:10.1155/2014/524383 · Cited by 6
Small fiber neuropathy in irritable bowel syndrome.
Motaghi, P., Adibi, I., Adibi, P., & Ghasemi, M. (2024) · Gastroenterology and hepatology from bed to bench. · doi:10.22037/ghfbb.v17i1.2827 · Cited by 5
Treatment of Posttraumatic Abdominal Autonomic Neuropathy Manifesting as Functional Dyspepsia and Chronic Constipation: An Integrative East-West Approach
Shubov, A., & Taw, L. B. (2015) · Global Advances in Health and Medicine · doi:10.7453/gahmj.2014.081 · Cited by 4
Effect of Stress on Gastrointestinal Motility
Gué, M. (2006) · Elsevier eBooks · doi:10.1016/b978-012088394-3/50032-5 · Cited by 4
Irritable bowel syndrome in obstructive sleep apnea: a preliminary Egyptian study
Saeed, A. M., & Galal, I. (2017) · Egyptian Journal of Bronchology · doi:10.4103/1687-8426.217636 · Cited by 3
Brain Asymmetry and Stress: New Perspectives in Psychophysiologically Oriented Psychosomatic Research
Papousek, I., & Schulter, G. (2002) · Psychology science · Cited by 3
The Brain–Gut Axis
Farmer, A. D., & Aziz, Q. (2015) · Wiley eBooks · doi:10.1002/9781118512074.ch14 · Cited by 2
Temporal Dynamics of Stress, Affect, and Abdominal Pain in IBS: Insights from a Clinical Sample
Pletikosić, S., Tončić, M., & Jančec, T. (2024) · Journal of Evidence-Based Psychotherapies · doi:10.24193/jebp.2024.2.9 · Cited by 2
Gender-Related Differences in Functional Bowel Disorders
Chang, L., & Heitkemper, M. M. (2004) · Principles of Gender-Specific Medicine · doi:10.1016/b978-012440905-7/50309-1 · Cited by 2
Self-citation
Association of decreased variation of coefficient R–R interval with ischemic colitis and small bowel obstruction
Arai, T., Yamada, H., Edagawa, T., Yoshida, S., Hikimoto, S., Sougawa, H., & Nakachi, K. (2020) · PLoS ONE · doi:10.1371/journal.pone.0228117 · Cited by 2
Irritable Bowel Syndrome
Videlock, E. J., & Chang, L. (2015) · Wiley eBooks · doi:10.1002/9781118512074.ch75 · Cited by 2
Relationship Between High Frequency Component of Heart Rate Variability and Delta EEG Power During Sleep in Women With Irritable Bowel Syndrome Compared to Healthy Women
Yang, P.-L., Kamp, K., Tu, Q., Chen, L. J., Cain, K. C., Heitkemper, M. M., & Burr, R. L. (2024) · Biological Research For Nursing · doi:10.1177/10998004241288791 · Cited by 1
Self-citation
NEUROBIOLOGICAL PERSPECTIVES ON TRAUMA
Kirmayer, L. J., Lemelson, R., & Barad, M. (2007) · Cambridge University Press eBooks · doi:10.1017/cbo9780511500008.004 · Cited by 1

Autonomic nervous system function in women with irritable bowel syndrome
Heitkemper, M., Jarrett, M., Cain, K. C., Burr, R., Levy, R. L., Feld, A., & Hertig, V. (2001) · Digestive Diseases and Sciences · doi:10.1023/a:1010671514618 · Cited by 145
Self-citation
Autonomic nervous system function during sleep among women with irritable bowel syndrome
Jarrett, M. E., Burr, R. L., Cain, K. C., Rothermel, J. D., Landis, C. A., & Heitkemper, M. M. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-9943-9 · Cited by 46
Self-citation
Sex Specific Alterations In Autonomic Function In Patients With Irritable Bowel Syndrome.
Nayem, M., Begum, N., Ferdousi, S., Rahman, M. T., Rahman, M., & Ahmed, M. N. U. (2013) · Journal of Dhaka National Medical College & Hospital · doi:10.3329/jdnmch.v19i2.77712
Autonomic cardiovascular responses are impaired in women with irritable bowel syndrome
Waring, W. S., Chui, M., Japp, A., Nicol, E. F., & Ford, M. J. (2004) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000135362.35665.49 · Cited by 83
Autonomic functioning in irritable bowel syndrome measured by heart rate variability: A meta‐analysis
Liu, Q., Wang, E. M., Yan, X. J., & Chen, S. L. (2013) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12092 · Cited by 69

Authors: Heitkemper, M., Burr, R. L., Jarrett, M., Hertig, V., Lustyk, M. K., & Bond, E. F.
Affiliations: University of Washington (US)
ORCID: Heitkemper, Margaret
Burr, Robert L.
Venue: Digestive Diseases and Sciences
Publisher: Springer Science and Business Media LLC
Published: 1998-09
Volume: 43
Issue: 9
Pages: 2093-2098
ISSN: 0163-2116 (ISSN-L)
1573-2568
DOI: 10.1023/a:1018871617483
OpenAlex: W1488685077
Cited by: 117
References: 16
Citations by year: 2026: 1 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 6 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 8 · 2014: 6 · 2013: 3 · 2012: 7
FWCI: 5.98
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Digestive Diseases and Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Nursing Research (NR04101)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords: irritable bowel syndrome, autonomic imbalance, heart rate variability, vagal tone, sympathovagal balance, women, menstrual cycle, luteal phase, sleep, gastrointestinal symptoms
MeSH terms: Adult, Autonomic Nervous System, Colonic Diseases, Functional, Female, Heart Rate, Humans, Middle Aged, Parasympathetic Nervous System, Vagus Nerve, Case-Control Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Evidence for Autonomic Nervous System Imbalance in Women with Irritable Bowel Syndrome

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks