The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Epigenetic aspects of somaclonal variation in plants
Abstract
Somaclonal variation is manifested as cytological abnormalities, frequent qualitative and quantitative phenotypic mutation, sequence change, and gene activation and silencing. Activation of quiescent transposable elements and retrotransposons indicate that epigenetic changes occur through the culture process. Epigenetic activation of DNA elements further suggests that epigenetic changes may also be involved in cytogenetic instability through modification of heterochromatin, and as a basis of phenotypic variation through the modulation of gene function. The observation that DNA methylation patterns are highly variable among regenerated plants and their progeny provides evidence that DNA modifications are less stable in culture than in seed-grown plants. Future research will determine the relative importance of epigenetic versus sequence or chromosome variation in conditioning somaclonal variation in plants.
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“This epigenetic variability, which frequently is observed at phenotype level, reflects, in reality, the adaptations of the cellular processes to the various constraints of the in vitro cultivation technology, that usually implies sequential dedifferentiation (formation of callus) and re-differentiation (regeneration of plants) [91,95,96,97,98,99,100].”
From Somaclonal Variation—Advantage or Disadvantage in Micropropagation of the Medicinal Plants (2023) · cites this paper as [95]
Citations
Cites
Somaclonal variation — a novel source of variability from cell cultures for plant improvement
Larkin, P. J., & Scowcroft, W. R. (1981) · Theoretical and Applied Genetics · doi:10.1007/bf02342540 · Cited by 3,002
The Significance of Responses of the Genome to Challenge
McClintock, B. (1984) · Science · doi:10.1126/science.15739260 · Cited by 2,638
Cell culture and somatic cell genetics of plants
Bogorad, L., Constabel, F., baron, S., & Vasil, I. K. (1984) · Cited by 1,322
An epigenetic mutation responsible for natural variation in floral symmetry
Cubas, P., Vincent, C. A., & Coen, E. (1999) · Nature · doi:10.1038/43657 · Cited by 1,262
Epigenetics: Regulation Through Repression
Wolffe, A. P., & Matzke, M. A. (1999) · Science · doi:10.1126/science.286.5439.481 · Cited by 1,261
Epigenetic mechanisms of gene regulation
Russo, V. E. A., Martienssen, R. A., & Riggs, A. D. (1996) · Cold Spring Harbor Laboratory eBooks · Cited by 1,105
Plant Tissue and Cell Culture.
Hammond, H. D., & Street, H. E. (1974) · Bulletin of the Torrey Botanical Club · doi:10.2307/2484649 · Cited by 867
Retrotransposons of rice involved in mutations induced by tissue culture.
Hirochika, H., Sugimoto, K., Otsuki, Y., Tsugawa, H., & Kanda, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7783 · Cited by 748
Genetic instability of plant tissue cultures: breakdown of normal controls.
Phillips, R. L., Kaeppler, S. M., & Olhoft, P. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5222 · Cited by 582
Self-citationThe Chromosomal Basis Of Somaclonal Variation
Lee, M., & Phillips, R. L. (1988) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.39.1.413 · Cited by 400
Research works printed but not linked: 6
- Bayliss, M.W. 1980. Chromosomal variation in plant tissues in culture. Int. Rev. Cytol. Suppl. 11A: 113–144.
- Brettell, R.I.S., Dennis, E.S., Scowcroft, W.R. and Peacock, W.J. 1986. Molecular analysis of a somaclonal variant of alcohol dehydrogenase. Mol. Gen. Genet. 202: 335–344.
- D'Amato, F. 1977. Cytogenetics of differentiation in tissue and cell cultures. In: J. Reinert and V.P.S. Bajaj (Eds.) Plant Cell, Tissue, and Organ Culture, Springer-Verlag, New York, pp. 343–357.
- Larkin, P.J. 1987. Somaclonal variation: history, method, and meaning. Iowa State J. 61: 393–434.
- Lee, M.L. and Phillips, R.L. 1987b. Genetic variability in progeny of regenerated maize (Zea mays L.) plants. Genome 29: 344–355.
- Olhoft, P.M. 1996. DNA methylation pattern changes induced by maize tissue culture. M.S. thesis, University of Minnesota, St. Paul, MN.
Cited by
Sorted by citations
High-frequency modification of plant genes using engineered zinc-finger nucleases
Townsend, J. A., Wright, D. A., Winfrey, R. J., Fu, F., Maeder, M. L., Joung, J. K., & Voytas, D. F. (2009) · Nature · doi:10.1038/nature07845 · Cited by 747
Somaclonal Variation in Plants: Causes and Detection Methods
Bairu, M. W., Aremu, A. O., & Van Staden, J. (2011) · Plant Growth Regulation · doi:10.1007/s10725-010-9554-x · Cited by 674
Transposable Elements Contribute to Activation of Maize Genes in Response to Abiotic Stress
Makarevitch, I., Waters, A. J., West, P. T., Stitzer, M. C., Hirsch, C. N., Ross‐Ibarra, J., & Springer, N. M. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1004915 · Cited by 474
Epigenetic regulation of transposable elements in plants
Lisch, D. (2009) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.59.032607.092744 · Cited by 469
Somaclonal variations and their applications in horticultural crops improvement
Krishna, H., Alizadeh, M., Singh, D., Singh, U., Chauhan, N., Eftekhari, M., & Sadh, R. K. (2016) · 3 Biotech · doi:10.1007/s13205-016-0389-7 · Cited by 436
Metadata
- Authors
- Kaeppler, S. M., Kaeppler, H. F., & Rhee, Y.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Kaeppler, Shawn M.
- Venue
- Plant Molecular Biology
- Published
- 2000-06
- Volume
- 43
- Issue
- 2-3
- Pages
- 179-188
- ISSN
- 0167-4412 (ISSN-L)
- 1573-5028
- OpenAlex
- W2119370926
- Cited by
- 743
- References
- 69
- Citations by year
- 2026: 17 · 2025: 12 · 2024: 15 · 2023: 14 · 2022: 36 · 2021: 27 · 2020: 30 · 2019: 32 · 2018: 37 · 2017: 33 · 2016: 37 · 2015: 47 · 2014: 40 · 2013: 47 · 2012: 43
- FWCI
- 3.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Plant Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Agriculture
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant tissue culture and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Genetic and Mutation Studies
- Keywords
- somaclonal variation, epigenetic modifications, DNA methylation, transposable elements, retrotransposons, gene silencing, gene activation, heterochromatin, cytogenetic instability, plant tissue culture, epigenetic inheritance
- MeSH terms
- Clone Cells, Plants, Genetic Variation, Transcriptional Activation, Gene Expression Regulation, Plant, Plant Cells
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