CoChat
Sign Up
Cited by 172Vitamin C and Antioxidants ResearchAntioxidant Activity and Oxidative StressPhytochemicals and Antioxidant Activities

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Pharmacokinetic Model of Ascorbic Acid in Healthy Male Volunteers During Depletion and Repletion

Graumlich, James F., Ludden, Thomas M., Conry-Cantilena, Cathy, Cantilena, Louis R., Wang, Yaohui, Levine, Mark·1997·Pharmaceutical Research
DOI 10.1023/a:1012186203165
Open this paper in CoChat — free account

Abstract

Purpose To develop a new pharmacokinetic model for ascorbic acid (vitamin C) since no previously published model describes ascorbic acid absorption and disposition over a broad physiologic range of doses and plasma concentrations.Methods A new model was developed through exploratory simulations. The model was fitted to pharmacokinetic data obtained from seven healthy volunteers who underwent ascorbic acid depletion then gradual repletion. Concentrations of ascorbic acid were measured in plasma and urine. Final pharmacokinetic model parameter estimates were obtained using nonlinear regression analysis.Results The new model included saturable absorption, distribution and renal tubular reabsorption parameters. The model described ascorbic acid concentrations in plasma, cells, and urine during depletion and gradual repletion phases with a residual error less than 15%.Conclusions The model was useful for obtaining a new understanding of the likely causes for the complex concentration-time profile observed during gradual repletion. At doses of 200 to 2500 mg per day, the plateau in pre-dose concentrations is largely due to apparent saturation of tissue uptake and less a function of oral bioavailability and renal excretion than previously thought.

Overview

Integrity signals

Registry

Crossref · 10.1023/a:1012186203165

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 5

  1. J. King, R. W. Welch, Y. Wang, K. R. Dhariwal, C. Conry-Cantilena, and M. Levine. Am. J. Clin. Nutr. (1997) in press.
  2. S. L. Beal, and L. B. Sheiner. NONMEM User's Guide Parts I–VI, NONMEM Project Group, Division of Clinical Pharmacology, University of California, San Francisco, 1992.
  3. Food and Nutrition Board. Recommended Dietary Allowances, 10th ed., National Academy Press, Washington, DC, 1989.
  4. Food and Nutrition Board. In Committee of Dietary Allowances (eds) Recommended Dietary Allowances, 9th ed., National Academy of Sciences, Washington, DC, 1980, pp. 72–81.
  5. Food and Nutrition Board. How should the Recommended Dietary Allowances be Revised, National Academy Press, Washington, DC 1994.

Cited by

Sorted by citations

See all 172

Related

See all

Metadata

Authors
Graumlich, J. F., Ludden, T. M., Conry-Cantilena, C., Cantilena, L. R., Wang, Y., & Levine, M.
Affiliations
  • Peoria campus of the University of Illinois System (US)
  • University of Nebraska Medical Center (US)
  • Uniformed Services University of the Health Sciences (US)
  • National Institutes of Health (US)
Corresponding author
Graumlich, James F.
ORCID
Venue
Pharmaceutical Research
Publisher
Springer Science and Business Media LLC
Published
1997-09
Volume
14
Issue
9
Pages
1133-1139
ISSN
  • 0724-8741 (ISSN-L)
  • 1573-904X
DOI
10.1023/a:1012186203165
OpenAlex
W1489783301
Cited by
172
References
25
Citations by year
2026: 1 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 12 · 2020: 11 · 2019: 10 · 2018: 5 · 2017: 8 · 2016: 6 · 2015: 9 · 2014: 9 · 2013: 7 · 2012: 9
FWCI
3.03
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Pharmaceutical Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service (224-88-3002)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK-92-0032)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords
vitamin C, pharmacokinetic modeling, vitamin C depletion, saturable absorption, tubular reabsorption, oral bioavailability, healthy men
MeSH terms
Adult, Ascorbic Acid, Biological Availability, Humans, Male, Models, Biological, Prospective Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review