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Cited by 438Vitamin C and Antioxidants ResearchAntioxidant Activity and Oxidative StressFolate and B Vitamins Research

Distribution of ascorbic acid, metabolites and analogues in man and animals

Hornig, Dietrich·1975·Annals of the New York Academy of Sciences
DOI 10.1111/j.1749-6632.1975.tb29271.x
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  • Erythorbic acid and D-ascorbic acid are partly active as vitamin C but are poorly retained by tissues and more rapidly excreted from the human body.

    “Its epimer erythorbic acid (Figure 1B, also known as isoascorbic acid or D-araboascorbic acid), which is used as a food additive, and its enantiomer D-ascorbic acid (Figure 1C) are also partly active as vitamin C. However, they are only poorly retained by tissues and are more rapidly excreted from the human body [7,8,9,10].”

    From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [8]

  • Vitamin C absorption is relatively slow, as maximal plasma levels are reached after 2-4 h.

    “In general, vitamin C absorption is relatively slow, as maximal plasma levels are reached after 2–4 h [6,8,40,58].”

    From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [8]

  • Physiologically high vitamin C levels (2-10 mM) are found in neurons and endocrine cells, particularly the adrenal and pituitary gland, apparently related to the synthesis of hormones and neuro-mediators.

    “Physiologically high levels (2–10 mM) are found in neurons and endocrine cells (particularly, the adrenal and pituitary gland), which is apparently related to the synthesis of hormones and neuro-mediators described below [4,6,8,72,73].”

    From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [8]

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Authors
Hornig, D.
Affiliations
F. Hoffmann-La Roche AG (CH)
Corresponding author
Hornig, Dietrich
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
1975-09
Volume
258
Issue
1
Pages
103-118
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1111/j.1749-6632.1975.tb29271.x
OpenAlex
W1969982879
Cited by
438
References
49
Citations by year
2026: 1 · 2025: 7 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 9 · 2020: 17 · 2019: 6 · 2018: 5 · 2017: 11 · 2016: 8 · 2015: 10 · 2014: 13 · 2013: 13 · 2012: 10
FWCI
0.65
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 11429 d)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
Keywords
vitamin C, tissue distribution, human, animals
MeSH terms
Adrenal Glands, Animals, Ascorbic Acid, Brain, Dehydroascorbic Acid, Guinea Pigs, Humans, Male, Organ Specificity, Parotid Gland, Pituitary Gland, Species Specificity, Submandibular Gland, Sulfuric Acids, Testis

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