The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.
Density and Distribution of Hippocampal Neurotransmitter Receptors in Autism: An Autoradiographic Study
Abstract
Neuropathological studies in autistic brains have shown small neuronal size and increased cell packing density in a variety of limbic system structures including the hippocampus, a change consistent with curtailment of normal development. Based on these observations in the hippocampus, a series of quantitative receptor autoradiographic studies were undertaken to determine the density and distribution of eight types of neurotransmitter receptors from four neurotransmitter systems (GABAergic, serotoninergic [5-HT], cholinergic, and glutamatergic). Data from these single concentration ligand binding studies indicate that the GABAergic receptor system (3[H]-flunitrazepam labeled benzodiazepine binding sites and 3[H]-muscimol labeled GABA(A) receptors) is significantly reduced in high binding regions, marking for the first time an abnormality in the GABA system in autism. In contrast, the density and distribution of the other six receptors studied (3[H]-80H-DPAT labeled 5-HT1A receptors, 3[H]-ketanserin labeled 5-HT2 receptors, 3[H]-pirenzepine labled M1 receptors, 3[H]-hemicholinium labeled high affinity choline uptake sites, 3[H]-MK801 labeled NMDA receptors, and 3[H]-kainate labeled kainate receptors) in the hippocampus did not demonstrate any statistically significant differences in binding.
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“Additionally, other studies have reported reduced GABAA [129, 130] and GABAB [124, 130] receptor density and system activity in the brains of autistic patients.”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [129]
Citations
Cites
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Self-citationMolecular biology of GABA A receptors
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Neocortical excitation/inhibition balance in information processing and social dysfunction
Yizhar, O., Fenno, L. E., Prigge, M., Schneider, F., Davidson, T. J., O’Shea, D. J., Sohal, V. S., Goshen, I., Finkelstein, J., Paz, J. T., et al. (2011) · Nature · doi:10.1038/nature10360 · Cited by 2,454
Robertson, C. E., & Baron-Cohen, S. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.112 · Cited by 1,157
Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder
Dawson, G. (2008) · Development and Psychopathology · doi:10.1017/s0954579408000370 · Cited by 1,138
Neuroanatomic observations of the brain in autism: a review and future directions
Bauman, M. L., & Kemper, T. L. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.09.006 · Cited by 919
Self-citationAdvancing the understanding of autism disease mechanisms through genetics
de la Torre-Ubieta, L., Won, H., Stein, J. L., & Geschwind, D. H. (2016) · Nature Medicine · doi:10.1038/nm.4071 · Cited by 827
Metadata
- Authors
- Blatt, G. J., Fitzgerald, C. M., Guptill, J. T., Booker, A. B., Kemper, T. L., & Bauman, M. L.
- Affiliations
- Boston University (US)
- Corresponding author
- Blatt, Gene J.
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2001-12
- Volume
- 31
- Issue
- 6
- Pages
- 537-543
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- OpenAlex
- W1488489801
- Cited by
- 322
- References
- 33
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 1 · 2023: 14 · 2022: 16 · 2021: 12 · 2020: 14 · 2019: 7 · 2018: 12 · 2017: 11 · 2016: 17 · 2015: 18 · 2014: 22 · 2013: 15 · 2012: 23
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, hippocampus, neurotransmitter receptors, receptor density, GABAergic system, benzodiazepine binding site, GABAA receptor, serotonin receptors, 5-HT1A receptor, 5-HT2 receptor, M1 muscarinic receptor, NMDA receptor, kainate receptors, limbic system
- MeSH terms
- Adolescent, Adult, Autistic Disorder, Autoradiography, Binding Sites, Cell Count, Flunitrazepam, Hippocampus, Humans, Male, Muscimol, Receptors, Neurotransmitter, Receptors, GABA, GABA Modulators, Culture Techniques
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