Neuropathology of Infantile Autism
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Thomas L. Kemper, MD, Margaret Bauman, MD; Neuropathology of Infantile Autism, Journal of Neuropathology & Experimental Neurology, Volume 57, Issue 7, 1 July 19
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In autistic individuals, neurons of the deep cerebellar nuclei differ in size according to age: cases over 21 show small pale neurons significantly decreased in number, while childhood cases ages 5-13 show unusually large and plentiful neurons.
“All of the autistic cases over the age of 21 years showed small pale neurons that were significantly decreased in number, whereas in all of the childhood cases, ages 5–13 years, the neurons in these same nuclear groups were unusually large and plentiful in numbers [14].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [14]
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- [1]1. Kanner L. Autistic disturbances of affective contact. Nervous Child 1943;2:217-50
- [4]4. Bryson SE, Clark BS, Smith IM. First report of a Canadian epidemiological study of autistic syndromes. J Child Psychol Psychiatry 1988;29:433–45
- [7]7. Darby JH. Neuropathological aspects of psychosis in childhood. J Autism Childhood Schizophrenia 1976;6:339–52
- [8]8. Boucher J, Warrington EK. Memory deficits in early infantile autism: Some similarities to the amnestic syndrome. Br J Psychol 1976;67:73-87
- [9]9. Delong GR. A neuropsychological interpretation of infantile autism. In: Rutter M, Schopler E, eds. Autism. New York: Plenum Press, 1978:207-18
- [10]10. Damasio AR, Maurer RG. A neurological model for childhood autism. Arch Neurol 1978;35:777–86
- [11]11. Maurer RG, Damasio AR. Childhood autism from the point of view of behavioral neurology. J Aut Dev Disord 1982;12:195–205
- [12]12. Coleman M. Studies of the autistic syndromes. In: Katzman R, ed. Congenital and acquired cognitive disorders. New York: Raven Press, 1979:265–303
- [13]13. Vilensky JA, Damasio AR, Maurer RG. Gait disturbances in patients with autistic behavior. Arch Neurol 1981;38:646–49
- [14]14. Ornitz EM, Ritvo ER. Neurophysiologic mechanisms underlying perceptual inconsistency in autistic and schizophrenic children. Arch Gen Psychiatry 1986;19:22–27
- [15]15. Bauman ML, Filipek PA, Kemper TL. Early infantile autism. Int Rev Neurobiol 1997;41:367–86
- [16]16. Piven J, Bailey BS, Ranson BJ, Arndt S. An MRI Study of the corpus callosum in autism. Am J Psychiatry 1997;154:1051–56
- [17]17. Gaffney GR, Kuperman S, Tsai LY, Minchin S. Morphological evidence for brain stem involvement in infantile autism. Biol Psychiatry 1988;24:578–86
- [18]18. Hsu M, Yeung-Courchesne R, Courchesne E, Press GA. Absence of pontine abnormality in infantile autism. Arch Neurol 1991;48: 1160-63
- [19]19. Hashimoto T, Tayama M, Murakawa K, Yoshimoto T, Miyazaki M, Harada M, Kuroda Y. Development of the brainstem and cerebellum in autistic patients. J Autism Dev Disord 1995;25:1–18
- [20]20. Hauser SL, Delong GR, Rosman NP. Pneumographic findings in the infantile autism syndrome. Brain 1975;98:667–88
- [21]21. Hier DB, LeMay M, Rosenberger PB. Autism and unfavorable leftright asymmetries of the brain. J Aut Dev Disord 1979;9:153–59
- [23]23. Saitoh O, Courchesne E, Egaas B, Lincoln AJ, Schreibman L. Cross-sectional area of the posterior hippocampus in autistic patients with cerebellar and corpus callosum abnormalities. Neurology 1995;45:317–24
- [22]22. Creasey H, Rumsey JM, Schwartz M, Duara R, Rapoport JL, Ra-opn u n mt amnt mt mrt in mroon umetric computed tomography. Arch Neurol 1986;43:669–72
- [24]24. Horwitz B, Rumsey JM, Grady CL, Rapoport SI. The cerebral metabolic ladscape in autism. Arch Neurol 1988;45:749–55
- [25]25. Minshew NJ, Goldstein G, Dombrowski SM, Panchalingam K, Pettegrew JW. A preliminary 31P MRS study of autism: Evidence for undersynthesis and increased degradation of brain membranes. Biol Psychiatry 1993;33:762–73
- [26]26. Haznedar MM, Buchsbaum MS, Metzger M, Solimando A, Spiegel-Cohen J, Hollander E. Anterior cingulate gyrus volume and glucose metabolism in autistic disorder. Am J Psychiatry 1997;154: 1047-50
- [27]27. Chugani DC, Muzik O, Rothermel R, Behen M, Chakraborty P, Mangner T, da Silva EA, Chugani HT. Altered serotonin synthesis in the dentatothalamocortical pathway in autistic boys. Ann Neurol 1997;42:666-69
- [5]5. Tanoue Y, Oda S, Asano F, Kawashima K. Epidemiology of infantile autism in southern Ibaraki, Japan: Differences in prevalence in birth cohorts. J Aut Dev Disord 1988;18:155–66
- [28]28. Zilbovicius M, Garreau B, Samson Y, Remy P, Barthelemy C, Syrota A, Lelord G. Delayed maturation of the frontal cortex in childhood autism. Am J Psychiatry 1995;152:248–52
- [29]29. Piven J, Arndt S, Bailey J, Andreasen N. Regional brain enlargement in autism: A magnetic resonance imaging study. J Am Acad Child Adolesc Psychiatry 1996;35:530–36
- [30]30. Bailey A, Luthert P, Bolton P, LeCouteur A, Rutter M. Autism and megalencephaly. Lancet 1993;34:1225–26
- [6]6. Gillberg C, Svendsen P. Childhood psychosis and computed tomographic brain scan findings. J Autism Dev Disord 1983;13:19–32
- [31]31. Aarkrog T. Organic factors in infantile psychosis and borderline 55. Kluver H, Bucy P. Preliminary analysis of functions of the temporal lobes in monkeys. Arch Neurol Psychiatry 1939;42:979–1000
- [2]2. psychosis. Retrospective study of 45 cases subjected to pneumoencephalography. Dan Med Bull 1968;15:283-88
- [32]32. Williams RS, Hauser SL, Purpura DP, Delong GR, Swisher CN. Autism and mental retardation. Arch Neurol 1980;37:749–53
- [33]33. Ritvo ER, Freeman BJ, Scheibel AB, Duong T, Robinson H, Guthrie D, Ritvo A. Lower Purkinje cell counts in the cerebella of four autistic subjects: Initial findings of the UCLA-NSAC autopsy research report. Amer J Psychiatry 1986;146:862–66
- [56]56. Terzian H, Delle-Ore G. Syndrome of Kluver and Bucy reproduced il l ias 5s: 3:373-80 - 57. Mishkin M, Aggleton JP. Multiple functional contributors of the amygdala in the monkey from the amygdaloid complex. In: BenAri Y, ed. INSERM Symposium, no. 20. Amsterdam: Elsevier North Holland Medical Press, 1981:409-19
- [34]34. Coleman PD, Romano J, Lapham L, Simon W. Cell counts in cerebral cortex of an autistic patient. J Autism Dev Disord 1985;15: 245-45
- [58]58. Murray EA, Mishkin M. Amygdaloidectomy impairs crossmodal association in monkeys. Science 1985;228:604–6
- [35]35. Rodier PM, Ingram JL, Tisdale B, Nelson S, Roman J. Embryological origins for autism: Developmental anomalies of the cranial nerve nuclei. J Comp Neurol 1996;370:247–61
- [36]36. Guerin P, Lyon G, Barthelemy C, Sostak E, Chevrollier V, Garreau B, Lelord G. Neuropathological study of a case of autistic syndrome with severe mental retardation. Dev Med Child Neurol 1996;38: 203-11
- [37]37. Bauman ML, Kemper TL. Histoanatomic observations of the brain in early infantile autism. Neurology 1985;35:866–74
- [38]38. Bauman ML, Kemper TL. Neuroanatomic observations of the brain in autism. In: Bauman ML, Kemper TL, eds. The neurobiology of autism. Baltimore: Johns Hopkins University Press, 1994:119–45
- [40]40. Dekaban AS, Sadowsky BS. Changes in brain weights during the span of human life: Relation of brain weights to body heights and body weights. Ann Neurol 1978;4:345–56
- [41]41. Raymond GV, Bauman ML, Kemper TL. Hippocampus in autism: A Golgi analysis. Acta Neuropathol 1996;91:117–19
- [42]42. Bauman ML, Kemper TL. Neuroanatomical observations of the brain in autism. In: Panksepp J, ed. Advances in biological psychiatry. New York: JAI Press, 1995:1–26
- [43]43. Arin DM, Bauman ML, Kemper TL. The distribution of Purkinje cell loss in the cerebellum in autism (abstract). Neurol 1991;41:307
- [44]44. Bauman ML, Kemper TL. Observations on the Purkinje cells in the cerebellar vermis in autism (abstract). J Neuropathol Exp Neurol 1996;55:613
- [45]45. Holmes G, Stewart TG. On the connection of the inferior olives with the cerebellum in man. Brain 1908;31:125–37
- [47]47. Yakovlev PI, Lecours A-R. The myelogenetic cycles of regional maturation of the brain. In: Minkowsi A, ed. Regional development of the brain in early life. Oxford and Edenburgh: Blackwell Scientific Publications, 1964:3-70
- [48]48. Norman RM. Cerebellar atrophy associated with etat marbre of the basal ganglia. J Neurol Psychiatry 1940;3:311–18
- [50]50. Eccles JC, Ito M, Szentagothai J. The cerebellum as a neuronal machine. New York: Springer, 1967:1–335
- [51]51. Rakic P. Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electron microscopic study in macacus rhesus. J Comp Neurol 1971;141:283–312
- [52]52. Rakic P, Sidman RL. Histogenesiș of cortical layers in human cerebellum particularly the lamina dissecans. J Comp Neurol 1970; 139:473-500
- [59]59. Bachevalier J, Merjanian PM. The contribution of medial temporal lobe structures in infantile autism: A neurobehavioral study in primates. In: Bauman ML, Kemper TL, eds. The neurobiology of autism. Baltimore: Johns Hopkins University Press, 1994:146–69
- [60]60. Malkova L, Mishkin M, Suomi SJ, Bachevalier J. Socioemotional behavior in adult rhesus monkeys after early versus late lesions of the medial temporal lobe. Ann New York Acad Sci 1977;807:538–40
- [61]61. Mishkin M, Appenzeller T. The anatomy of memory. Sci Am 1987; 256:80-89
- [62]62. Bachevalier J. Ontogenetic development of habit and memory formation in primates. Ann New York Acad Sci 1990; 608:457–77
- [63]63. Mishkin M. Memory in monkeys is severely impaired by combined buaptn p t aae at aads o ue 1978;273:297–98
- [64]64. Mahut H, Zola-Morgan S, Moss M. Hippocampal resections impair associative learning and recognition memory in the monkey. J Neurosci 1982;2:1214–29
- [65]65. Zola-Morgan S, Squire LR, Amaral DG. Human amnesia and the medial temporal region: Enduring memory impairment following bilateral lesions limited to field CA1 of the hippocampus. J Neurosci 1986;6:2950-67
- [66]66. Alvarez P, Zola-Morgan S, Squire LR. Damage limited to the hipros mons o mn mon aoi monkeys. J Neurosci 1995;15:3796–807
- [67]67. Meunier M, Bachevalier J, Mishkin M, Murray EA. Effects on visual recognition of combined and separate ablations of the ento-. rhinal and perirhinal cortex in rhesus monkeys. J Neurosci 1993; 13:5418-32
- [68]68. Overman W, Bachevalier J, Turner M, Peuster A. Object recognition versus object discrimination: Comparison between human infants and infant monkeys. Behav Neurosci 1992;106:15–29
- [69]69. Rosene DL, Van Hoesen GW. The hippocampal formation of the primate brain. A review of some comparative aspects of cytoarchitecture and connections. In: Jones EG, Peters A, eds. Cerebral Cortex, Vol. 6. New York and London: Plenum Press, 1987:345–456
- [70]70. Amaral DG, Price JL, Pitkänen A, Carmichael ST. Anatomical organization of the primate amygdala complex. In: Aggleton JP, ed. The amygdala: Neurobiological aspects of emotion, memory and mental dysfunction. New York: Wiley-Liss and Sons, 1992:1-66
- [71]71. Blatt GJ, Rosene DL. Organization of direct hippocampal efferent projections to the cerebral cortex of the rhesus monkey: Projections from CA1, prosubiculum, and subiculum to the temporal lobe. J Comp Neurol 1998;392:92–114
- [72]72. Heath RG, Harper JW. Ascending projections of the cerebellar fastigial nucleus to the hippocampus, amygdala and other temporal lobe sites; evoked potential, and histological studies in monkeys and cats. Exp Neurol 1974;45:268–87
- [73]73. Heath RG, Dempsey CW, Fontana CJ, Myers WA. Cerebellar stimulation: Effects on septal region, hippocampus and amygdala of cats and rats. Biol Psychiatry 1978;113:501–29
- [53]53. Gautier JC, Blackwood W. Enlargement of the inferior olivary nucleus in association with lesions of the central tegmental tract or dentate nucleus. Brain 1961;84:241–-64
- [74]74. Keele SW, Ivry R. Does the cerebellum provide a common computation for diverse tasks? A timing hypothesis. Ann NY Acad Sci 1990;608:179–207
- [75]75. Leiner HC, Leiner AL, Dow RS. Cerebrocerebellar learning loops in apes and humans. Ital J Neurol Sci 1987;8:425–36
- [54]54. Papez JW. A proposed mechanism of emotion. Arch Neurol Psychiatry1937;38:725-43
- [76]76. Peterson SF, Fox PT, Posner MI, Mintum MA, Raichle ME. Posi- 80. Schmahmann JD. An emerging concept. The cerebellar contribution to higher function. Arch Neurol 1991;48:1178-87
- [2]2. tron emission tomographic studies in processing of single words. J Cog Neurosci 1989;1:153-70
- [78]78. Akshoomoff NA, Courchesne E. A new role for the cerebellum in cognitive operations. Behav Neurosci 1992;106:731–38
- [79]79. Grafman J, Litvan I, Massaquoi S, Stewart M, Sirigu A, Hallett M. Cognitive planning deficit in patients with cerebellar atrophy. Neurology 1992;42:1493–96
- [81]81. Brancha V, Zhao L, Wunderlich DA, Morrissy SJ, Bloedel JR. Patients with cerebellar lesions cannot acquire but are able to retain conditioned eyeblink reflexes. Brain 1997;120:1401-13 Received March 11, 1998 Revision received April 3, 1998 Accepted April 6, 1998
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Stigler, K. A., McDonald, B. C., Anand, A., Saykin, A. J., & McDougle, C. J. (2011) · Brain Research · doi:10.1016/j.brainres.2010.11.076 · Cited by 197 · see citing works
COURCHESNE, E., REDCAY, E., MORGAN, J. T., & KENNEDY, D. P. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050285 · Cited by 192 · see citing works
Simms, M. L., Kemper, T. L., Timbie, C. M., Bauman, M. L., & Blatt, G. J. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0568-2 · Cited by 183 · see citing works
Self-citationPursuit eye movement deficits in autism
Takarae, Y. (2004) · Brain · doi:10.1093/brain/awh307 · Cited by 193 · see citing works
Atypical involvement of frontostriatal systems during sensorimotor control in autism
Takarae, Y., Minshew, N. J., Luna, B., & Sweeney, J. A. (2007) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2007.03.008 · Cited by 171 · see citing works
Wills, S., Cabanlit, M., Bennett, J., Ashwood, P., Amaral, D. G., & Van de Water, J. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.07.007 · Cited by 163 · see citing works
The environment as an etiologic factor in autism: a new direction for research
London, E. A. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108s3401 · Cited by 177 · see citing works
Focal cortical dysplasias in autism spectrum disorders
Casanova, M. F., El-Baz, A. S., Kamat, S. S., Dombroski, B. A., Khalifa, F., Elnakib, A., Soliman, A., Allison-McNutt, A., & Switala, A. E. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-67 · Cited by 150 · see citing works
Cerebellum, Language, and Cognition in Autism and Specific Language Impairment
Hodge, S. M., Makris, N., Kennedy, D. N., Caviness, V. S., Howard, J., McGrath, L., Steele, S., Frazier, J. A., Tager-Flusberg, H., & Harris, G. J. (2010) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-009-0872-7 · Cited by 143 · see citing works
DeStefano, F., Bhasin, T. K., Thompson, W. W., Yeargin-Allsopp, M., & Boyle, C. (2004) · PEDIATRICS · doi:10.1542/peds.113.2.259 · Cited by 135 · see citing works
Motor Performance and Anatomic Magnetic Resonance Imaging (MRI) of the Basal Ganglia in Autism
Hardan, A. Y., Kilpatrick, M., Keshavan, M. S., & Minshew, N. J. (2003) · Journal of Child Neurology · doi:10.1177/08830738030180050801 · Cited by 131 · see citing works
Neuronal Density and Architecture (Gray Level Index) in the Brains of Autistic Patients
Casanova, M. F., Buxhoeveden, D. P., Switala, A. E., & Roy, E. (2002) · Journal of Child Neurology · doi:10.1177/088307380201700708 · Cited by 121 · see citing works
Mukaetova‐Ladinska, E. B., Arnold, H., Jaros, E., Perry, R., & Perry, E. (2004) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2004.00574.x · Cited by 115 · see citing works
Oculomotor abnormalities parallel cerebellar histopathology in autism
Takarae, Y. (2004) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.022491 · Cited by 110 · see citing works
Bramham, J., Ambery, F., Young, S., Morris, R., Russell, A., Xenitidis, K., Asherson, P., & Murphy, D. (2009) · Autism · doi:10.1177/1362361309103790 · Cited by 95 · see citing works
Brain morphometry volume in autistic spectrum disorder: a magnetic resonance imaging study of adults
Hallahan, B., Daly, E. M., McAlonan, G., Loth, E., Toal, F., O'Brien, F., Robertson, D., Hales, S., Murphy, C., Murphy, K. C., et al. (2009) · Psychological Medicine · doi:10.1017/s0033291708003383 · Cited by 94 · see citing works
Review: Cortical construction in autism spectrum disorder: columns, connectivity and the subplate
Hutsler, J. J., & Casanova, M. F. (2016) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12227 · Cited by 94 · see citing works
Kikuchi, Y., Senju, A., Tojo, Y., Osanai, H., & Hasegawa, T. (2009) · Child Development · doi:10.1111/j.1467-8624.2009.01342.x · Cited by 90 · see citing works
Casanova, M. F., El-Baz, A., Mott, M., Mannheim, G., Hassan, H., Fahmi, R., Giedd, J., Rumsey, J. M., Switala, A. E., & Farag, A. (2009) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0681-4 · Cited by 90 · see citing works
Greco, C. M., Navarro, C. S., Hunsaker, M. R., Maezawa, I., Shuler, J. F., Tassone, F., Delany, M., Au, J. W., Berman, R. F., Jin, L.-W., et al. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-2 · Cited by 90 · see citing works
Bailey, A. J., Braeutigam, S., Jousmäki, V., & Swithenby, S. J. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04061.x · Cited by 86 · see citing works
Neural Hyperexcitability in Autism Spectrum Disorders
Takarae, Y., & Sweeney, J. (2017) · Brain Sciences · doi:10.3390/brainsci7100129 · Cited by 82 · see citing works
Altamura, C., Dell'Acqua, M., Moessner, R., Murphy, D., Lesch, K., & Persico, A. M. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhl051 · Cited by 79 · see citing works
Altered morphology of motor cortex neurons in the VPA rat model of autism
Snow, W. M., Hartle, K., & Ivanco, T. L. (2008) · Developmental Psychobiology · doi:10.1002/dev.20337 · Cited by 72 · see citing works
The mouse Engrailed genes: A window into autism
KUEMERLE, B., GULDEN, F., CHEROSKY, N., WILLIAMS, E., & HERRUP, K. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.09.009 · Cited by 60 · see citing works
Malformation of the superior olivary complex in an animal model of autism
Lukose, R., Schmidt, E., Wolski, T. P., Murawski, N. J., & Kulesza, R. J. (2011) · Brain Research · doi:10.1016/j.brainres.2011.05.013 · Cited by 59 · see citing works
GABAergic Cerebellar System In Autism: A Neuropathological And Developmental Perspective
Blatt, G. J. (2005) · International Review of Neurobiology · doi:10.1016/s0074-7742(05)71007-2 · Cited by 56 · see citing works
Wegiel, J., Flory, M., Kuchna, I., Nowicki, K., Ma, S. Y., Imaki, H., Wegiel, J., Frackowiak, J., Kolecka, B. M., Wierzba-Bobrowicz, T., et al. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0183-5 · Cited by 47 · see citing works
Heterogeneous association between engrailed‐2 and autism in the CPEA network
Brune, C. W., Korvatska, E., Allen‐Brady, K., Cook, E. H., Dawson, G., Devlin, B., Estes, A., Hennelly, M., Hyman, S. L., McMahon, W. M., et al. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30585 · Cited by 40 · see citing works
Martin, L. A., Escher, T., Goldowitz, D., & Mittleman, G. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2004.00067.x · Cited by 36 · see citing works
Stem cells and modeling of autism spectrum disorders
Freitas, B. C. G., Trujillo, C. A., Carromeu, C., Yusupova, M., Herai, R. H., & Muotri, A. R. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2012.09.017 · Cited by 27 · see citing works
- Authors
- Kemper, T. L., & Bauman, M.
- Affiliations
- Boston University (US)
- Corresponding author
- Kemper, Thomas L.
- ORCID
- Bauman, Margaret
- Venue
- Journal of Neuropathology and Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-07
- Volume
- 57
- Issue
- 7
- Pages
- 645-652
- ISSN
- 0022-3069 (ISSN-L)
- OpenAlex
- W2084550269
- Cited by
- 585
- References
- 0
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 15 · 2023: 17 · 2022: 7 · 2021: 13 · 2020: 29 · 2019: 13 · 2018: 12 · 2017: 22 · 2016: 17 · 2015: 25 · 2014: 22 · 2013: 26 · 2012: 37
- FWCI
- 8.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- infantile autism, neuropathology, autism spectrum disorder
- MeSH terms
- Adult, Animals, Autistic Disorder, Brain, Brain Stem, Cerebellum, Cerebral Cortex, Child, Humans
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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