The mitochondrial uncoupling protein: structural and genetic studies.
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UCP1 hinders the establishment of, or dissipates, a proton gradient of sufficient magnitude to sustain the synthetic activity of the mitochondrial ATPase, thus driving continuous accelerated electron transport.
“UCP1 hinders the establishment of, or dissipates, a proton gradient of sufficient magnitude to sustain the synthetic activity of the mitochondrial ATPase (150, 153-155), thus driving continuous accelerated electron transport.”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [155]
In brown adipose tissue, electron transport is greatly accelerated due to tissue-specific expression of the mitochondrial UCP1.
“In this tissue, electron transport is greatly accelerated due to tissue-specific expression of the mitochondrial UCP1.”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [155]
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- Authors
- Ricquier, D., & Bouillaud, F.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- ORCID
- Bouillaud, Frédéric
- Venue
- Progress in nucleic acid research and molecular biology
- Publisher
- Elsevier
- Published
- 1997
- Volume
- 56
- Pages
- 83-108
- ISSN
- 0079-6603 (ISSN-L)
- OpenAlex
- W193153926
- Cited by
- 52
- References
- 61
- Citations by year
- 2025: 1 · 2020: 2 · 2016: 2 · 2015: 1 · 2013: 1
- FWCI
- 9.90
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in nucleic acid research and molecular biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- mitochondrial uncoupling proteins, mitochondrial permeability transition pore, protein structure, gene structure, mitochondrial membrane permeability
- MeSH terms
- Uncoupling Protein 1, Amino Acid Sequence, Animals, Adipose Tissue, Brown, Carrier Proteins, Gene Expression Regulation, Ion Channels, Membrane Proteins, Mitochondria, Molecular Sequence Data, Protein Conformation, Recombinant Proteins, Uncoupling Agents, Adipocytes, Mitochondrial Proteins, Rats
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