The DOI matches its Crossref record; 59 of the 60 references it cites were found in a registry or an index.
Lifestyle determinants of serum insulin-like growth-factor-I (IGF-I), C-peptide and hormone binding protein levels in British women
Abstract
Objective This study aims to identify the lifestyle determinants of insulin-like growth factor-I (IGF-I) and its main binding proteins (IGFBPs), C-peptide, and sex hormone-binding globulin (SHBG) to help elucidate the mechanism through which lifestyle factors may affect cancer risk. Methods This study is based on a sample of 292 British women, aged 20-70 years, whose lifestyle characteristics were assessed using a self-administered questionnaire and whose serum hormone concentrations were measured using immunoassays. Results Age was a strong determinant of both IGF-I and IGFBP levels; women aged 65-70 years had significantly lower IGF-I and IGFBP-3 concentrations and significantly higher IGFBP-1 and IGFBP-2 concentrations than women aged 20-24 years. Body mass index (BMI) was not strongly associated with IGF-I, although women with a BMI of 26-27.9 kg/m2 had a higher IGF-I concentration compared with both lean (BMI Conclusions Our data show that age is a major determinant of both IGF-I and its main binding proteins in women. BMI has strong effects on IGFBPs, C-peptide, and SHBG, but its effects on IGF-I remain unclear. The possible effect of physical activity on IGFBP-1 requires further investigation.
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“IGFBP-2 is a member of the insulin and IGF signaling pathway, and IGFBP-2 levels in humans are inversely associated with BMI, fat mass, insulin levels, and fatty liver index [26‐30].”
From Tirzepatide as monotherapy improved markers of beta-cell function and insulin sensitivity in type 2 diabetes (SURPASS-1). (2023) · cites this paper as [28]
Citations
Cites
Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*
Jones, J. I. W., & Clemmons, D. R. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-1-3 · Cited by 4,488
Obesity and insulin resistance
Kahn, B. B., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10842 · Cited by 3,345
Circulating concentrations of insulin-like growth factor I and risk of breast cancer
Hankinson, S. E., Willett, W. C., Colditz, G. A., Hunter, D. J., Michaud, D. S., Deroo, B. J., ROSNER, B. A., Speizer, F. E., & Pollak, M. (1998) · The Lancet · doi:10.1016/s0140-6736(97)10384-1 · Cited by 1,822
Nutritional Regulation of the Insulin-Like Growth Factors*
Thissen, J., Ketelslegers, J., & Underwood, L. E. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-1-80 · Cited by 1,575
Ma, J., Pollak, M., Giovannucci, E. L., Chan, J. M., Tao, Y., Hennekens, C. H., & Stampfer, M. J. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.7.620 · Cited by 1,118
Ríboli, E. (1997) · International Journal of Epidemiology · doi:10.1093/ije/26.suppl_1.s6 · Cited by 957
Human growth hormone and human aging
CORPAS, E., HARMAN, S. M., & BLACKMAN, M. R. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-1-20 · Cited by 911
PLYMATE, S. R., MATEJ, L. A., JONES, R. E., & FRIEDL, K. E. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-3-460 · Cited by 693
Kaaks, R. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.19.1592 · Cited by 655
Self-citationEnergy balance and cancer: the role of insulin and insulin-like growth factor-I
Kaaks, R., & Lukanova, A. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns200070 · Cited by 610
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Items 101–104 of 104
PHYSICAL ACTIVITY ACROSS THE LIFE COURSE AND RISK OF PRE- AND POST-MENOPAUSAL BREAST CANCER
Kobayashi, L. C. (2012) · QSpace (Queen's University Library)
O’Leary, M. F. (2018) · University of Birmingham Institutional Research Archive (University of Birmingham)
Osório–Costa, F., Rocha, G. Z., Dias, M. M., & Carvalheira, C. (2009) · Scopus
Adipositas und Karzinogenese des Mammakarzinoms
Distler, W., Kast, K., & Canzler, U. (2010) · Der Gynäkologe · doi:10.1007/s00129-010-2528-2
Metadata
- Authors
- Allen, N. E., Appleby, P. N., Kaaks, R., Rinaldi, S., Davey, G. K., & Key, T. J.
- Affiliations
- Cancer Research UK (GB)
- Centre international de recherche sur le cancer (FR)
- Corresponding author
- Allen, Naomi E.
- Venue
- Cancer Causes & Control
- Published
- 2003-02
- Volume
- 14
- Issue
- 1
- Pages
- 65-74
- ISSN
- 0957-5243 (ISSN-L)
- 1573-7225
- OpenAlex
- W332185995
- Cited by
- 104
- References
- 60
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 5 · 2012: 4
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Cancer Causes & Control (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- insulin-like growth factor I, IGF binding proteins, C-peptide, sex hormone-binding globulin, lifestyle factors, obesity, body mass index, physical activity, age, women, cancer risk, IGFBP-1, IGFBP-3
- MeSH terms
- Adult, Age Factors, C-Peptide, Female, United Kingdom, Humans, Insulin-Like Growth Factor I, Life Style, Middle Aged, Motor Activity, Neoplasms, Risk, Sex Hormone-Binding Globulin, Body Mass Index, Insulin-Like Growth Factor Binding Protein 1
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