CoChat
Sign Up
Cited by 104Growth Hormone and Insulin-like Growth FactorsCancer Risks and FactorsHypothalamic control of reproductive hormones

The DOI matches its Crossref record; 59 of the 60 references it cites were found in a registry or an index.

Lifestyle determinants of serum insulin-like growth-factor-I (IGF-I), C-peptide and hormone binding protein levels in British women

Allen, Naomi E., Appleby, Paul N., Kaaks, Rudolf, Rinaldi, Sabina, Davey, Gwyneth K., Key, Timothy J.·2003·Cancer Causes & Control
DOI 10.1023/a:1022518321634
Open this paper in CoChat — free account

Abstract

Objective This study aims to identify the lifestyle determinants of insulin-like growth factor-I (IGF-I) and its main binding proteins (IGFBPs), C-peptide, and sex hormone-binding globulin (SHBG) to help elucidate the mechanism through which lifestyle factors may affect cancer risk. Methods This study is based on a sample of 292 British women, aged 20-70 years, whose lifestyle characteristics were assessed using a self-administered questionnaire and whose serum hormone concentrations were measured using immunoassays. Results Age was a strong determinant of both IGF-I and IGFBP levels; women aged 65-70 years had significantly lower IGF-I and IGFBP-3 concentrations and significantly higher IGFBP-1 and IGFBP-2 concentrations than women aged 20-24 years. Body mass index (BMI) was not strongly associated with IGF-I, although women with a BMI of 26-27.9 kg/m2 had a higher IGF-I concentration compared with both lean (BMI Conclusions Our data show that age is a major determinant of both IGF-I and its main binding proteins in women. BMI has strong effects on IGFBPs, C-peptide, and SHBG, but its effects on IGF-I remain unclear. The possible effect of physical activity on IGFBP-1 requires further investigation.

Overview

Integrity signals

Registry

Crossref · 10.1023/a:1022518321634

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Cited by

Sorted by citations

See all 104

Related

See all

Metadata

Authors
Allen, N. E., Appleby, P. N., Kaaks, R., Rinaldi, S., Davey, G. K., & Key, T. J.
Affiliations
  • Cancer Research UK (GB)
  • Centre international de recherche sur le cancer (FR)
Corresponding author
Allen, Naomi E.
ORCID
Venue
Cancer Causes & Control
Publisher
Springer Science and Business Media LLC
Published
2003-02
Volume
14
Issue
1
Pages
65-74
ISSN
  • 0957-5243 (ISSN-L)
  • 1573-7225
DOI
10.1023/a:1022518321634
OpenAlex
W332185995
Cited by
104
References
60
Citations by year
2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 5 · 2012: 4
FWCI
5.70
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Cancer Causes & Control (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
insulin-like growth factor I, IGF binding proteins, C-peptide, sex hormone-binding globulin, lifestyle factors, obesity, body mass index, physical activity, age, women, cancer risk, IGFBP-1, IGFBP-3
MeSH terms
Adult, Age Factors, C-Peptide, Female, United Kingdom, Humans, Insulin-Like Growth Factor I, Life Style, Middle Aged, Motor Activity, Neoplasms, Risk, Sex Hormone-Binding Globulin, Body Mass Index, Insulin-Like Growth Factor Binding Protein 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review