Cited by 327Cancer, Hypoxia, and MetabolismCancer Cells and MetastasisMechanisms of cancer metastasis

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The hypoxic tumour microenvironment and metastatic progression

Subarsky, Patrick, Hill, Richard P.·2003·Clinical & Experimental Metastasis

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Abstract

The microenvironment of solid tumours contains regions of poor oxygenation and high acidity. Growing evidence from clinical and experimental studies points to a fundamental role for hypoxia in metastatic progression. Prolonged hypoxia increases genomic instability, genomic heterogeneity, and may act as a selective pressure for tumour cell variants. Hypoxia can also act in an epigenetic fashion, altering the expression of genes. Hypoxia-induced changes in gene expression alter non-specific stress responses, anaerobic metabolism, angiogenesis, tissue remodeling, and cell-cell contacts. Experimental studies have demonstrated that inhibition of proteins involved in these processes can modify metastasis formation, suggesting a causal role in metastatic progression. Recent advances in high-throughput screening techniques have allowed identification of many hypoxia-induced genes that are involved in the processes associated with metastasis. Here we review the epigenetic control of gene expression by the hypoxic microenvironment and its potential contribution to metastatic progression.

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Authors: Subarsky, P., & Hill, R. P.
Affiliations: University of Toronto (CA)
Corresponding author: Hill, Richard P.
ORCID: Hill, Richard P.
Venue: Clinical & Experimental Metastasis
Publisher: Springer Science and Business Media LLC
Published: 2003-05
Volume: 20
Issue: 3
Pages: 237-250
ISSN: 0262-0898 (ISSN-L)
1573-7276
DOI: 10.1023/a:1022939318102
OpenAlex: W122518273
Cited by: 327
References: 132
Citations by year: 2026: 1 · 2024: 2 · 2023: 7 · 2022: 8 · 2021: 12 · 2020: 10 · 2019: 9 · 2018: 4 · 2017: 23 · 2016: 17 · 2015: 12 · 2014: 14 · 2013: 17 · 2012: 9
FWCI: 7.56
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Clinical & Experimental Metastasis (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
Keywords: tumor hypoxia, tumor microenvironment, metastatic progression, genomic instability, genomic heterogeneity, epigenetic regulation, hypoxia-induced gene expression, anaerobic metabolism, angiogenesis, tissue remodeling, cell-cell contact, high-throughput screening, anti-metastatic agents
MeSH terms: Animals, Humans, Neoplasm Metastasis, Neoplasm Proteins, Neoplasms, Signal Transduction, Cell Hypoxia, Gene Expression Regulation, Neoplastic, Disease Progression

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