The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Stability and Release Performance of a Series of Pegylated Copolymeric Micelles
Abstract
Purpose The aim of this work is to evaluate the capability of a series of biocompatible amphiphilic copolymers as a nano-sized drug carrier.Methods The influences of the type of lactone monomer, the feed molar ratios of lactone/PEG, and the molecular weight of PEG on the performance and release behavior of micelles are investigated.Results These pegylated amphiphilic copolymers efficiently form micelles with a low CMC value in the range of 10(6)-10(-7) M. The average particle size of micelles is approximately 100 nm. The phenomenon of increasing particle size as increasing the chain length of poly(lactone) block is observed. The different hydrophobicity, based on chemical structure of poly(lactone), accounts for different interaction strength between indomethacin and hydrophobic inner core, which further influences the drug loading in copolymeric micelles and their release character. In addition, the PCL/PEG/PCL micellar solutions maintain their sizes at 4 degrees C for 8 weeks without occurring significant aggregation or dissociation.Conclusions A series of biocompatible pegylated amphiphilic copolymers have been elucidated possessing micellization potential to form nano-sized micelles in an aqueous environment, which enable incorporate hydrophobic drug and regulate drug release.
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“The hydrophobic block of block copolymers is intended to solubilize poorly soluble drugs in the core and control the release of the drug from the polymeric micelles [36–38].”
From Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval. (2020) · cites this paper as [37]
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Metadata
- Authors
- Lin, W.-J., Juang, L.-W., & Lin, C.-C.
- Affiliations
- National Taiwan University (TW)
- Venue
- Pharmaceutical Research
- Published
- 2003-04
- Volume
- 20
- Issue
- 4
- Pages
- 668-673
- ISSN
- 0724-8741 (ISSN-L)
- 1573-904X
- OpenAlex
- W159284353
- Cited by
- 125
- References
- 21
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 10 · 2013: 5 · 2012: 7
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Pharmaceutical Research (publishedVersion)
- Funders
- National Science Council
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
- Keywords
- polymeric micelles, drug delivery, indomethacin, controlled drug release, critical micelle concentration, particle size, hydrophobicity, drug loading, micelle stability, PEG molecular weight, lactone monomers
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