Src family kinases in tumor progression and metastasis

CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES

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Three-dimensional structure of the tyrosine kinase c-Src

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DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA

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Crystal structure of the Src family tyrosine kinase Hck

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A SARCOMA OF THE FOWL TRANSMISSIBLE BY AN AGENT SEPARABLE FROM THE TUMOR CELLS

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Tyrosine kinase/p21ras/MAP‐kinase pathway activation by estradiol‐receptor complex in MCF‐7 cells.

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Identification of a transformation-specific antigen induced by an avian sarcoma virus

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Role of Src expression and activation in human cancer

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Pathways of metastasis suppression in bladder cancer

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Anoikis‑resistant human osteosarcoma cells display significant angiogenesis by activating the Src kinase‑mediated MAPK pathway

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CXC chemokine ligand‐13 promotes metastasis via CXCR5‐dependent signaling pathway in non‐small cell lung cancer

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Progestagen component in combined hormone replacement therapy in postmenopausal women and breast cancer risk: A debated clinical issue

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Small molecule tyrosine kinase inhibitors in pancreatic cancer

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Cancer Stem Cell–Suppressing Activity of Chrysotoxine, a Bibenzyl from Dendrobium pulchellum

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Src family kinases mediate betel quid-induced oral cancer cell motility and could be a biomarker for early invasion in oral squamous cell carcinoma.

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Quantitative mass spectrometry for colorectal cancer proteomics

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Interaction between Ras and Src clones causes interdependent tumor malignancy via Notch signaling in Drosophila

Enomoto, M., Takemoto, D., & Igaki, T. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.07.002 · Cited by 29

A Regulatory Polymorphism at Position -309 in PTPRCAP Is Associated with Susceptibility to Diffuse-type Gastric Cancer and Gene Expression

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Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines

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Combined EGFR and c-Src Antisense Oligodeoxynucleotides Encapsulated with PAMAM Denderimers Inhibit HT-29 Colon Cancer Cell Proliferation

Nourazarian, A., Najar, A. G., Farajnia, S., Khosroushahi, A. Y., Pashaei‐Asl, R., & Omidi, Y. (2012) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2012.13.9.4751 · Cited by 27

Chapter 6 Cell and Molecular Biology of the Novel Protein Tyrosine‐Phosphatase‐Interacting Protein 51

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Src family kinase members have a common response to histone deacetylase inhibitors in human colon cancer cells

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Increases in c-Src Expression Level and Activity Do Not Promote the Growth of Human Colorectal Carcinoma Cells In Vitro and In Vivo

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SRC and MEK Co-inhibition Synergistically Enhances the Anti-tumor Effect in Both Non-small-cell Lung Cancer (NSCLC) and Erlotinib-Resistant NSCLC

Yuan, M., Xu, L.-F., Zhang, J., Kong, S.-Y., Wu, M., Lao, Y.-Z., Zhou, H., Zhang, L., & Xu, H. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00586 · Cited by 26

Carcinogenicity of nicotine and signal pathways in cancer progression: a review

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Discovery of novel purine derivatives with potent and selective inhibitory activity against c-Src tyrosine kinase

Huang, H., Ma, J., Shi, J., Meng, L., Jiang, H., Ding, J., & Liu, H. S. (2010) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2010.05.032 · Cited by 26

c- Src and its role in cystic fibrosis

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Targeted mass spectrometry: An emerging powerful approach to unblock the bottleneck in phosphoproteomics

Osinalde, N., Aloria, K., Ibarra, M. J. O., & Kratchmarova, I. (2017) · Journal of Chromatography B · doi:10.1016/j.jchromb.2017.04.026 · Cited by 27

Curcumin and Its New Derivatives: Correlation between Cytotoxicity against Breast Cancer Cell Lines, Degradation of PTP1B Phosphatase and ROS Generation

Kostrzewa, T., Wołosewicz, K., Jamrozik, M., Drzeżdżon, J., Siemińska, J., Jacewicz, D., Górska‐Ponikowska, M., Kołaczkowski, M., Łaźny, R., & Kuban‐Jankowska, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910368 · Cited by 26

Thymosin β4 induces proliferation, invasion, and epithelial-to-mesenchymal transition of oral squamous cell carcinoma

Hong, K., Lee, J., Hong, S., & Hong, S. (2015) · Amino Acids · doi:10.1007/s00726-015-2070-6 · Cited by 26

Src activation and translocation from focal adhesions to membrane ruffles contribute to formation of new adhesion sites

Hamadi, A., Deramaudt, T. B., Takeda, K., & Rondé, P. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8424-4 · Cited by 26

Serum starvation regulates E-cadherin upregulation via activation of c-Src in non-small-cell lung cancer A549 cells

Dong, S., Khoo, A., Wei, J., Bowser, R. K., Weathington, N. M., Xiao, S., Zhang, L., Ma, H., Zhao, Y., & Zhao, J. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00132.2014 · Cited by 27

Laser microdissection expression profiling of marginal edges of colorectal tumours reveals evidence of increased lactate metabolism in the aggressive phenotype

Thorn, C. C., Freeman, T. C., Scott, N., Guillou, P. J., & Jayne, D. G. (2008) · Gut · doi:10.1136/gut.2008.157255 · Cited by 27

Extracellular pressure stimulates colon cancer cell adhesion in vitro and to surgical wounds by Src (sarcoma protein) activation

van Zyp, J. V. D. V., Thamilselvan, V., Walsh, M. F., Polin, L., & Basson, M. D. (2004) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2004.07.005 · Cited by 28

Src Family Kinase Inhibitor Saracatinib (AZD0530) Impairs Oxaliplatin Uptake in Colorectal Cancer Cells and Blocks Organic Cation Transporters

Morrow, C. J., Ghattas, M. A., Smith, C. G., Bönisch, H., Bryce, R. A., Hickinson, D. M., Green, T. P., & Dive, C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0694 · Cited by 26

Targeting c-Src kinase enhances tamoxifen’s inhibitory effect on cell growth by modulating expression of cell cycle and survival proteins

Planas-Silva, M. D., & Hamilton, K. N. (2006) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-006-0398-z · Cited by 26

Multiple implications of 3-phosphoinositide-dependent protein kinase 1 in human cancer

Li, Y. (2010) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v1.i8.239 · Cited by 27

Crk Tyrosine Phosphorylation Regulates PDGF-BB–inducible Src Activation and Breast Tumorigenicity and Metastasis

Kumar, S., Lü, B., Davra, V., Hornbeck, P. V., Machida, K., & Birge, R. B. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0242 · Cited by 26

TrkB promotes laryngeal cancer metastasis via activation PI3K/AKT pathway

Jiang, L., Wang, Z., Liu, C., Gong, Z., Yang, Y., Kang, H., Li, Y., & Hu, G. (2017) · Oncotarget · doi:10.18632/oncotarget.21711 · Cited by 25

Caveolin‑1 enhances RANKL‑induced gastric cancer cell migration

Wang, Y., Song, Y., Che, X., Zhang, L., Wang, Q., Zhang, X., Qu, J., Li, Z., Xu, L., Zhang, Y., et al. (2018) · Oncology Reports · doi:10.3892/or.2018.6550 · Cited by 25

Reverse phase protein array identifies novel anti-invasion mechanisms of YC-1

Hong, B., Lui, V. W. Y., Hui, E. P., Lu, Y., Leung, H. S. Y., Wong, E. Y. L., Cheng, S.-H., Ng, M. H. L., Mills, G. B., & Chan, A. T. �. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.10.021 · Cited by 25

Inhibition of T24 human bladder carcinoma cell migration by RNA interference suppressing the expression of HD-PTP.

Mariotti, M., Castiglioni, S., & Maier, J. A. (2009) · Cancer Letters · doi:10.1016/j.canlet.2008.08.017 · Cited by 29

Simultaneous inhibition of Src and Aurora kinases by SU6656 induces therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo.

Arai, R., Tsuda, M., Watanabe, T., Ose, T., Obuse, C., Maenaka, K., Minami, A., & Ohba, Y. (2012) · European Journal of Cancer · doi:10.1016/j.ejca.2011.12.028 · Cited by 27

Divergent Modulation of Src-Family Kinase Regulatory Interactions with ATP-Competitive Inhibitors

Leonard, S. E., Register, A. C., Krishnamurty, R., Brighty, G. J., & Maly, D. J. (2014) · ACS Chemical Biology · doi:10.1021/cb500371g · Cited by 25

Non-immunoglobulin scaffold proteins: Precision tools for studying protein-protein interactions in cancer

Martin, H. L., Bedford, R., Heseltine, S. J., Tang, A. A.-S., Haza, K. Z., Rao, A., McPherson, M. J., & Tomlinson, D. C. (2018) · New Biotechnology · doi:10.1016/j.nbt.2018.02.008 · Cited by 24

Bosutinib: A Novel Second-Generation Tyrosine Kinase Inhibitor

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Emerging Intrinsic Therapeutic Targets for Metastatic Breast Cancer

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Tyrosine phosphorylation-mediated YAP1-TFAP2A interactions coordinate transcription and trastuzumab resistance in HER2+ breast cancer

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(1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-olide, a Cembrenolide Diterpene from Soft Coral Lobophytum sp., Inhibits Growth and Induces Apoptosis in Human Colon Cancer Cells through Reactive Oxygen Species Generation

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Modulation of arsenic-induced epidermal growth factor receptor pathway signalling by resveratrol

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Phase I study of dasatinib (BMS‐354825) in Japanese patients with solid tumors

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p130Cas substrate domain signaling promotes migration, invasion, and survival of estrogen receptor-negative breast cancer cells

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CRF2 Signaling Is a Novel Regulator of Cellular Adhesion and Migration in Colorectal Cancer Cells

Ducarouge, B., Pelissier-Rota, M. A., Lainé, M. G., Cristina, N., Vachez, Y. M., Scoazec, J., Bonaz, B. L., & Jacquier‐Sarlin, M. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079335 · Cited by 24

Chromosomal deletion, promoter hypermethylation and downregulation of FYN in prostate cancer

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Regulation of SRC Kinases by microRNA-3607 Located in a Frequently Deleted Locus in Prostate Cancer

Saini, S., Majid, S., Shahryari, V., Tabatabai, Z. L., Arora, S., Yamamura, S., Tanaka, Y., Dahiya, R., & Deng, G. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-14-0017 · Cited by 24

Src nuclear localization and its prognostic relevance in human osteosarcoma

Urciuoli, E., Coletta, I., Rizzuto, E., Vito, R. D., Petrini, S., D'Oria, V., Pezzullo, M., Milano, G. M., Cozza, R., Locatelli, F., et al. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26079 · Cited by 25

A novel BLK-induced tumor model

Petersen, D. L., Berthelsen, J., Willerslev-Olsen, A., Fredholm, S., Dabelsteen, S., Bonefeld, C. M., Geisler, C., & Woetmann, A. (2017) · Tumor Biology · doi:10.1177/1010428317714196 · Cited by 24

Bosutinib

Keller, G., Schafhausen, P., & Brümmendorf, T. H. (2009) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-642-01222-8_9 · Cited by 24

Kinase Inhibitors and Cytotoxic Drug Resistance

Grant, S., & Dent, P. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0001-4 · Cited by 24

PH006, a novel and selective Src kinase inhibitor, suppresses human breast cancer growth and metastasis in vitro and in vivo

Ma, J., Huang, H., Chen, S.-M., Chen, Y., Xin, X., Lin, L., Ding, J., Liu, H. S., & Meng, L. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1302-4 · Cited by 23

New Structural Perspectives in G Protein-Coupled Receptor-Mediated Src Family Kinase Activation

Berndt, S., & Liebscher, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126489 · Cited by 25

Structure-based virtual screening of Src kinase inhibitors

Lee, K., Kim, J., Jeong, K., Lee, K. W., Lee, Y., Song, J. Y., Kim, M. S., Lee, G. S., & Kim, Y. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.02.054 · Cited by 23

Genetic Susceptibility on CagA-Interacting Molecules and Gene-Environment Interaction with Phytoestrogens: A Putative Risk Factor for Gastric Cancer

Yang, J. J., Cho, L. Y., Ko, K., Shin, A., Ma, S. H., Choi, B. Y., Han, D. S., Song, K. S., Kim, Y. S., Lee, J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031020 · Cited by 23

Episodic Src activation in uveal melanoma revealed by kinase activity profiling

Maat, W., el Filali, M., Mulder, A., Luyten, G. P. M., Gruis, N. A., Desjardins, L., Boender, P. J., Jager, M. J., & van der Velden, P. A. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605172 · Cited by 23

Pro-Metastatic Tumor–Stroma Interactions in Breast Cancer

Gangadhara, S., Barrett-Lee, P. J., Nicholson, R. I., & Hiscox, S. (2012) · Future Oncology · doi:10.2217/fon.12.134 · Cited by 23

Phase I and pharmacokinetic study of dasatinib and cetuximab in patients with advanced solid malignancies

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Profiling Y561-Dependent and -Independent Substrates of CSF-1R in Epithelial Cells

Knowlton, M. L., Selfors, L. M., Wrobel, C. N., Gu, T., Ballif, B. A., Gygi, S. P., Polakiewicz, R. D., & Brugge, J. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013587 · Cited by 23

Tris DBA palladium overcomes hypoxia-mediated drug resistance in multiple myeloma

de la Puente, P., Azab, F., Muz, B., Luderer, M. J., Arbiser, J. L., & Azab, A. K. (2015) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2015.1099645 · Cited by 23

PTTG1 Levels Are Predictive of Saracatinib Sensitivity in Ovarian Cancer Cell Lines

Nakachi, I., Helfrich, B., Spillman, M., Mickler, E. A., Olson, C., Rice, J., Coldren, C. D., Heasley, L., Geraci, M. W., & Stearman, R. S. (2016) · Clinical and Translational Science · doi:10.1111/cts.12413 · Cited by 23

Cytokinesis Failure Leading to Chromosome Instability in v-Src-Induced Oncogenesis

Nakayama, Y., Soeda, S., Ikeuchi, M., Kakae, K., & Yamaguchi, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040811 · Cited by 24

Dasatinib + Gefitinib, a non platinum-based combination with enhanced growth inhibitory, anti-migratory and anti-invasive potency against human ovarian cancer cells

Thibault, B., & Jean-Claude, B. (2017) · Journal of Ovarian Research · doi:10.1186/s13048-017-0319-2 · Cited by 23

Pleural adverse drugs reactions and protein kinase inhibitors: Identification of suspicious targets by disproportionality analysis from VigiBase

Mahé, J., de Campaigno, E. P., Chené, A., Montastruc, J., Despas, F., & Jolliet, P. (2018) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13693 · Cited by 23

Application of MM-GB/SA and WaterMap to SRC Kinase Inhibitor Potency Prediction

Kohlmann, A., Zhu, X., & Dalgarno, D. C. (2012) · ACS Medicinal Chemistry Letters · doi:10.1021/ml200222u · Cited by 23

Yes-mediated phosphorylation of focal adhesion kinase at tyrosine 861 increases metastatic potential of prostate cancer cells

Chatterji, T., Varkaris, A. S., Parikh, N. U., Song, J. H., Cheng, C.-J., Schweppe, R. E., Alexander, S., Davis, J. W., Troncoso, P., Friedl, P., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3391 · Cited by 22

The Influence of SRC-Family Tyrosine Kinases on Na,K-ATPase Activity in Lens Epithelium

Bozulic, L. D., Dean, W. L., & Delamere, N. A. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0809 · Cited by 23

Austalides V and W, new meroterpenoids from the fungus Aspergillus ustus and their antitumor activities

Antipova, T. V., Zaitsev, K. V., Oprunenko, Y. F., Zherebker, A., Rystsov, G. K., Zemskova, M. Y., Zhelifonova, V. P., Ivanushkina, N. E., & Kozlovsky, A. G. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.126708 · Cited by 22

Targeting eukaryotic elongation factor-2 kinase suppresses the growth and peritoneal metastasis of ovarian cancer

Erdoğan, M. A., Ashour, A. A., Yuca, E., Görgülü, K., & Özpolat, B. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.109938 · Cited by 22

Signaling by the tyrosine kinase Yes promotes liver cancer development

Guégan, J., Lapouge, M., Voisin, L., Saba-El-Leil, M. K., Tanguay, P., Lévesque, K., Brégeon, J., Mes‐Masson, A., Lamarre, D., Haibe‐Kains, B., et al. (2022) · Science Signaling · doi:10.1126/scisignal.abj4743 · Cited by 21

ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells

Cicero, J., Trouvilliez, S., Palma, M., Ternier, G., Decoster, L., Happernegg, E., Barois, N., Outryve, A. V., Dehouck, L., Bourette, R. P., et al. (2023) · Experimental Hematology and Oncology · doi:10.1186/s40164-023-00463-6 · Cited by 22

A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma

Zhong, L., Fu, X., Zou, C., Yang, L., Zhou, S. W., Yang, J., Tang, Y., Cheng, C., Li, L., Xiang, R., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.28944 · Cited by 22

c-Src Antisense Complexed with PAMAM Denderimes Decreases of c-Src Expression and EGFR-Dependent Downstream Genes in the Human HT-29 Colon Cancer Cell Line

Nourazarian, A., Pashaei‐Asl, R., Omidi, Y., & Najar, A. G. (2012) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2012.13.5.2235 · Cited by 22

Evaluation of the Clinical Significance of Focal Adhesion Kinase and Src Expression in Human Pancreatic Ductal Adenocarcinoma

Chatzizacharias, N. A., Giaginis, C., Zizi, D., Kouraklis, G. P., Karatzas, G., & Theocharis, S. E. (2010) · Pancreas · doi:10.1097/mpa.0b013e3181d7abcc · Cited by 22

c-Src regulates cell cycle proteins expression through protein kinase B/glycogen synthase kinase 3 beta and extracellular signal-regulated kinases 1/2 pathways in MCF-7 cells

Liu, X., Du, L., & Feng, R. (2013) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmt042 · Cited by 22

Elevated MED28 expression predicts poor outcome in women with breast cancer

Yoon, N. K., Maresh, E. L., Elshimali, Y., Li, A., Horvath, S., Seligson, D. B., Chia, D., & Goodglick, L. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-335 · Cited by 22

Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein

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Proteome-wide Tyrosine Phosphorylation Analysis Reveals Dysregulated Signaling Pathways in Ovarian Tumors

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