Src family kinases in tumor progression and metastasis

CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES

Thomas, S. Μ., & Brugge, J. S. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.513 · Cited by 2,537

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

Hunter, T. R., & Sefton, B. M. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1311 · Cited by 2,333

Three-dimensional structure of the tyrosine kinase c-Src

Xu, W., Harrison, S. C., & Eck, M. J. (1997) · Nature · doi:10.1038/385595a0 · Cited by 1,432

DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA

STEHELIN, D., VARMUS, H. E., BISHOP, J. M., & VOGT, P. K. (1976) · Nature · doi:10.1038/260170a0 · Cited by 1,321 · cited 2×

Regulation, substrates and functions of src

Brown, M. T., & Cooper, J. A. (1996) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(96)00003-0 · Cited by 1,193

Crystal structure of the Src family tyrosine kinase Hck

Sicheri, F., Moarefi, I., & Kuriyan, J. (1997) · Nature · doi:10.1038/385602a0 · Cited by 1,171

A SARCOMA OF THE FOWL TRANSMISSIBLE BY AN AGENT SEPARABLE FROM THE TUMOR CELLS

Rous, P. (1911) · Journal of Experimental Medicine · doi:10.1084/jem.13.4.397 · Cited by 1,051

Tyrosine kinase/p21ras/MAP‐kinase pathway activation by estradiol‐receptor complex in MCF‐7 cells.

Migliaccio, A., Domenico, M. D., Castoria, G., de Falco, A., Bontempo, P., Nola, E., & Auricchio, F. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00471.x · Cited by 950

Identification of a transformation-specific antigen induced by an avian sarcoma virus

Brugge, J. S., & Erikson, R. L. (1977) · Nature · doi:10.1038/269346a0 · Cited by 889

Role of Src expression and activation in human cancer

Irby, R., & Yeatman, T. J. (2000) · Oncogene · doi:10.1038/sj.onc.1203912 · Cited by 878

Additional file 1 of ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells

Cicero, J., Trouvilliez, S., Palma, M., Ternier, G., Decoster, L., Happernegg, E., Barois, N., Outryve, A. V., Dehouck, L., Bourette, R. P., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26651691

Additional file 1 of A versatile engineered extracellular vesicle platform simultaneously targeting and eliminating senescent stromal cells and tumor cells to promote tumor regression

Gong, L., Chen, Z., Feng, K., Luo, L., Zhang, J., Yuan, J., Ren, Y., Wang, Y., Zheng, X., & Li, Q. (2024) · Figshare · doi:10.6084/m9.figshare.25389425

Slap restricts oncogenic Src-family kinase signaling to maintain colonic epithelial homeostasis

Naim, D., HOUHOU, Z., Cauchois, F., Espie, K., Simon, V., Boublik, Y., Vives, F. L., Homayed, Z., Paul, C., Maillard, M., et al. (2026) · eLife · doi:10.64898/2026.01.05.697659

Upregulation of EphA2 by Src counteracts Src-induced loss of cell adhesion.

Takada, M., Murata, M., Soeda, S., Honda, T., Yuki, R., & Nakayama, Y. (2026) · Experimental Cell Research · doi:10.1016/j.yexcr.2026.114898

Signalisation oncogénique des tyrosine kinases et thérapies ciblées dans le cancer colorectal

Leroy, C. (2010) · theses.fr (ABES) · doi:10.70675/2ed0fd50z4cdfz44fazb610ze1e6911d3e30

Régulation de la signalisation oncogénique de Src par l'adaptateur SLAP dans les cellules de cancer colorectal

Naudin, C. (2012) · theses.fr (ABES) · doi:10.70675/2d33d548z48baz433bzab22za40a44ff2ad1

Régulation de l'invasion cellulaire induite par les tyrosine kinases dans le cancer du sein

Chevalier, C. (2014) · theses.fr (ABES) · doi:10.70675/692c8de1za82az4e5ez953bz5e90670eb75d

Mécanismes moléculaires de l'acquisition d'une sensibilité à l'apoptose induite par l'ABT-737 et d'une résistance à l'anoïkis de cellules coliques métastatiques

Maâmer-Azzabi, A. (2013) · theses.fr (ABES) · doi:10.70675/7d8f9d5aza8c5z4c20zb88fz33df091ac53b

Slap restricts oncogenic Src-family kinase signaling to maintain colonic epithelial homeostasisPreprint

Naim, D., HOUHOU, Z., Cauchois, F., Simon, V., Vives, F. L., Homayed, Z., Paul, C., Hahne, M., Pannequin, J., Nguyen, J., et al. (2026) · eLife · doi:10.7554/elife.110324.1

Rôle des complexes WASH et exocyste dans l’invasion tumorale

Monteiro, P. (2014) · theses.fr (ABES) · doi:10.70675/bc648be3z6f56z4ef5z9dd9z091f3adfc4bc

Les cellules initiatrices de tumeurs à l'origine de l'hétérogénéité d'expression de l'intégrine α5β1 dans les glioblastomes

Mercier, M.-C. (2018) · theses.fr (ABES) · doi:10.70675/273bcce1z8572z472ez9afbzca3fd562301c

La fonction suppresseur de tumeur de la protéine adaptatrice SLAP dans le cancer colorectal implique la régulation de la signalisation mTORC2

Mevizou, R. (2021) · theses.fr (ABES) · doi:10.70675/baa79427z3972z46a0zbf49zb12b1554e87f

QSAR Study for Developing a New c-SRC Tyrosine Kinase Inhibitors

Naanaa, M., Sliman, F., & Barakat, H. (2026) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2026.00295

Overview of Pyrazolo[1,5‐ a ]Pyrimidines Scaffold: Synthetic Strategies, Drug Synthesis, Structure–Activity Relationships, and Their Functional Fluorophores

Embaby, D., El-Rashedy, A. A. E., Hammad, S. F., & Elshaier, Y. A. M. M. (2026) · ChemistrySelect · doi:10.1002/slct.202506991

Ethanolic Extract of Bupleurum Falcatum L. Root Attenuates Chronic Stress-Induced Cancer Metastasis via Inhibition of Src Kinase

Jeong, J.-H., Park, H.-J., Chi, G., Choi, Y.-H., & Park, S. (2026) · Nutrition and Cancer · doi:10.1080/01635581.2026.2698769

AKAP12 is upregulated by base deletion at positions 61–78 in exon 3, leading to suppressed proliferation and metastasis of benzo[a]pyrene-transformed HBE cells

Hao, M., Fu, Y., Lin, Y., Wang, Y., Li, L., Fu, D., Yao, B., Fu, J., Zhou, Z., Su, J., et al. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.154389

Slap restricts oncogenic Src-family kinase signaling to maintain colonic epithelial homeostasisPreprint

Naim, D., HOUHOU, Z., Cauchois, F., Espie, K., Simon, V., Boublik, Y., Vives, F. L., Homayed, Z., Paul, C., Maillard, M., et al. (2026) · eLife · doi:10.7554/elife.110324.2

A phosphorylation switch governs KIF11’s mechanical output during mitosis

Šemić, A., Reddy, B. J. N., Muretta, J. M., Vandal, S. E., Thompson, A. F., Fonseca, C. L., Rosenfeld, S. S., Gross, S. P., & Stumpff, J. K. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2602415123

Integrated in silico and in vitro analysis identifies a co-expression pattern associated with cisplatin/5-FU treatment response and metastatic features in gastric cancer

Iranmehr, Z., Sharahi, H. Y., Eslahchi, C., Ghaemi, F., Wadji, M. B., Miri, S. R., & Ebrahimi, M. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12888-3

Breast cancer cells with decreased fibronectin-integrin adhesion strength attenuate the malignancy of its microenvironment

Burday, N., Guerrero-Barberà, G., Jayo, A., del Pino, M. M. S., Zapater, E. O., & Costell, M. (2026) · Matrix Biology · doi:10.1016/j.matbio.2026.102067

BindingDB Entry 50018282: Discovery and preliminary structure-activity relationship studies of novel benzotriazine based compounds as Src inhibitors.

BindingDB (2009) · UC San Diego · doi:10.7270/q2sn08mp

BindingDB Entry 50018286: Molecular hybrids: A five-year survey on structures of multiple targeted hybrids of protein kinase inhibitors for cancer therapy.

BindingDB (2024) · UC San Diego · doi:10.7270/q2tf02jj

BindingDB Entry 50033429: 3-substitued indoles: one-pot synthesis and evaluation of anticancer and Src kinase inhibitory activities.

BindingDB (2011) · UC San Diego · doi:10.7270/q2r49r44

BindingDB Entry 50018748: Recent researches for dual Aurora target inhibitors in antitumor field.

BindingDB (2024) · UC San Diego · doi:10.7270/q2tt4w5v

BindingDB Entry 50039806: Application of MM-GB/SA and WaterMap to SRC Kinase Inhibitor Potency Prediction.

BindingDB (2013) · UC San Diego · doi:10.7270/q2319wzm

BindingDB Entry 50032996: Synthesis of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates and evaluation of their Src kinase inhibitory and anticancer activities.

BindingDB (2011) · UC San Diego · doi:10.7270/q2p84c6b

BindingDB Entry 50030666: Structural basis for the inhibitor recognition of human Lyn kinase domain.

BindingDB (2010) · UC San Diego · doi:10.7270/q2tt4r1d

BindingDB Entry 50008313: Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361).

BindingDB (2021) · UC San Diego · doi:10.7270/q2z89gt1

BindingDB Entry 833: Identification of 7-Phenylaminothieno[3,2-b]pyridine-6-carbonitriles as a New Class of Src Kinase Inhibitors

BindingDB (2005) · UC San Diego · doi:10.7270/q2cv4fxn

BindingDB Entry 50018879: Design strategies, structure activity relationship and mechanistic insights for purines as kinase inhibitors.

BindingDB (2024) · UC San Diego · doi:10.7270/q21v5k7m

BindingDB Entry 4666: Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds.

BindingDB (2011) · UC San Diego · doi:10.7270/q2m61hrq

BindingDB Entry 50034330: One-pot regioselective synthesis of tetrahydroindazolones and evaluation of their antiproliferative and Src kinase inhibitory activities.

BindingDB (2012) · UC San Diego · doi:10.7270/q23x872p

BindingDB Entry 50037900: Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine--a potent, orally active Src kinase inhibitor with anti-tumor activity in preclinical assays.

BindingDB (2012) · UC San Diego · doi:10.7270/q29024mw

BindingDB Entry 50028533: Structure-based virtual screening of Src kinase inhibitors.

BindingDB (2010) · UC San Diego · doi:10.7270/q2v9880t

BindingDB Entry 50048974: An insight on synthetic and medicinal aspects of pyrazolo[1,5-a]pyrimidine scaffold.

BindingDB (2019) · UC San Diego · doi:10.7270/q2s184rn

BindingDB Entry 50040903: O-Aryla,ß-d-ribofuranosides: synthesis& highly efficient biocatalytic separation of anomers and evaluation of their Src kinase inhibitory activity.

BindingDB (2013) · UC San Diego · doi:10.7270/q23b619q

BindingDB Entry 50026867: Novel N9-arenethenyl purines as potent dual Src/Abl tyrosine kinase inhibitors.

BindingDB (2010) · UC San Diego · doi:10.7270/q2h41r78

BindingDB Entry 1655: Synthesis and Src Kinase Inhibitory Activity of a Series of 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-7-furyl-3-quinolinecarbonitriles.

BindingDB (2007) · UC San Diego · doi:10.7270/q28k779j

BindingDB Entry 50039227: Discovery of novel purine derivatives with potent and selective inhibitory activity against c-Src tyrosine kinase.

BindingDB (2012) · UC San Diego · doi:10.7270/q26h4jcq

BindingDB Entry 50003681: 7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as dual inhibitors of Src and Abl kinases.

BindingDB (2020) · UC San Diego · doi:10.7270/q2bp05hd

Pharmacologic Factors: Anaesthetic Agents that May Influence Cancer Outcomes: Local Anaesthetics

Borgeat, A., Schick, C., & Votta‐Velis, G. (2015) · Current anesthesiology reports · doi:10.1007/s40140-015-0112-y

The role of cell cycle control mechanisms in regulated and sustained cell proliferation

Hultman, T. (2013) · Epsilon Archive for Student Projects (University of Southampton)

Die Rolle der IGF-Achse in Kombination mit anderen Wachstumsfaktor-Signalwegen bei der Resistenz oder dem Ansprechen von kolorektalen Karzinomen auf eine Radiochemotherapie

Seemann, H. (2013) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-4083

Development of novel therapies for colorectal carcinoma using dietary indoles

Brookes, A. (2014) · Leicester Research Archive (University of Leicester)

Mitochondrion: A Novel Center for Cancer Cell Signaling

Miriyala, S., Holley, A. K., & Clair, D. K. S. (2014) · Springer eBooks · doi:10.1007/978-94-017-8984-4_1

The Role of Src in Solid Tumors

Wheeler, D. L., Iida, M., & Dunn, E. F. (2009) · The Oncologist · doi:10.1634/theoncologist.2009-0009 · Cited by 346

Regulation of Src Family Kinases in Human Cancers

Sen, B., & Johnson, F. M. (2011) · Journal of Signal Transduction · doi:10.1155/2011/865819 · Cited by 235

doi:10.1155/2011/865819 Review Article Regulation of Src Family Kinases in Human Cancers

Sen, B., & Johnson, F. M. (2011)

Proteínas cinasas de la familia SRC en el desarrollo del cáncer

Cruz, I. S. (2012)

Src Family Nonreceptor Tyrosine Kinases as Molecular Targets for Cancer Therapy

Johnson, F. M., & Gallick, G. E. (2007) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152007784111278 · Cited by 97